Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011854 (
type 1 diabetes
)
20,749
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The renal excretion of
3-methylhistidine
was measured in healthy human volunteers under different diets. The excretion of
3-methylhistidine
and total nitrogen was increased in 8 surgical patients. These findings are referred to an increased proteolysis mainly in the skeletal muscle. In four insulin-dependent diabetic patients (
IDDM
) the excretion of
3-methylhistidine
into urine was increased only when referred to body weight. The interpretation of the
3-methylhistidine
/creatinin ratio is discussed. In diabetic patients the total nitrogen excretion seems to be a better parameter for protein turnover than
3-methylhistidine
. The data suggest that
3-methylhistidine
excretion into urine is a suitable parameter for the determination of muscle protein turnover.
...
PMID:[3-Methylhistidine as a parameter for the determination of muscle proteolysis in the post-stress syndrome and in diabetes mellitus]. 643 16
