Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011854 (type 1 diabetes)
 20,749 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diabetic patients have an increased risk of prosthesis failure requiring revision surgery. Furthermore, skeletal defects are observed in conjunction with type 1 diabetes. Using a titanium particle-induced calvarial osteolysis model in diabetic mice, we investigated the effect of diabetes on the osteolytic process and the role of naringin in its prevention. Three groups each of nondiabetic or diabetic mice were treated with vehicle only, with particles only, or with particles then naringin for 10 days. Alteration of bone indices near the midline suture were then analyzed by microcomputed tomography scanning and histology. Serum levels of osteocalcin (OCN) and cross-linked N-telopeptide of type I collagen (NTx) were measured by enzyme-linked immunosorbent assay. The decreases in new bone formation (p < 0.05), calvaria thickness (p < 0.05), bone volume (p < 0.05), midline suture area (p < 0.05), and OCN concentration (p < 0.05) found in diabetic mice were normalized with naringin treatment. Diabetic state promoted particle-induced osteolysis. Naringin, an osteoanabolic agent, improved bone indices apparently by stimulating bone formation. Therefore, naringin may be beneficial in preventing and treating debris-mediated periprosthetic osteolysis after total joint replacement, especially in diabetics.
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PMID:Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model. 1982 55

Antiatherogenic and hypoglycemic effects of naringin are hereby investigated in type 1 diabetes. Wistar rats (n = 6) were treated daily with 1.0 mL of water (group 1), naringin (50 mg/kg) (groups 2 and 3, respectively), regular insulin (4 U/kg, subcutaneously, twice daily) (group 4), and simvastatin (20 mg/kg) (group 6). Groups 3, 4, 5, and 6 exhibited polydipsia and hyperglycemia after injection with streptozotocin (60 mg/kg body weight). Insulin, but not naringin, significantly lowered fasting blood glucose levels in diabetic rats. Plasma low-density lipoprotein cholesterol concentrations were significantly higher in nontreated diabetic rats (group 5) compared with control (group 1), whereas total and high-density lipoprotein cholesterol were significantly higher in naringin- and simvastatin-treated diabetic rats, respectively. Hepatic total cholesterol and triglycerides were significantly elevated in nontreated diabetic compared with the control, naringin-, insulin-, and simvastatin-treated diabetic rats, respectively. Hepatic 3-hydroxy-3-methyl-glutaryl CoA reductase and Acyl-CoA:cholesterol acyltransferase activities were significantly elevated in nontreated diabetic compared with the control, naringin-, and simvastatin-treated diabetic rats, respectively. However, plasma low-density lipoprotein to high-density lipoprotein ratio was significantly higher in nontreated diabetic compared with the control, whereas naringin and simvastatin significantly reduced the ratio in diabetic rats. Naringin is not hypoglycemic but improves atherogenic index in type 1 diabetes.
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PMID:Naringin ameliorates atherogenic dyslipidemia but not hyperglycemia in rats with type 1 diabetes. 2196 58

Oxidative stress is one of the important causes of the type 1 diabetes induced changes in the sperm quality. Bioflavonoids, Rutin 10 mg/Kg and Naringin 10 mg/Kg were evaluated for their protective effects on sperm parameters, oxidative stress, and histopathology of type 1 diabetic rats. Results demonstrated the reduction in sperm count, sperm motility and vitality in diabetic rats. Mass drug administration (MDA) levels were increased and superoxide dismutase (SOD) catalase levels were decreased. Histopathological changes were evident and in accordance with the above results. In the treatment groups, both Rutin and Naringin in combination with insulin treatment in diabetic rats produced protection from diabetes and improved all the sperm parameters, decreased the MDA levels and increased the SOD and catalase levels. Protection was evident in histological examination. Our data suggests that the possible protection of testicular tissue and reproduction from oxidative stress have been induced by type 1 diabetes mellitus.
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PMID:Protective Effect of Rutin and Naringin on Sperm Quality in Streptozotocin (STZ) Induced Type 1 Diabetic Rats. 2425 Mar 92

Cardiac hypertrophy (CH) in type 1 diabetes mellitus is attributed to increased oxidative stress-associated activation of c-Jun Nuclear Kinase (JNK). We investigated the effects of naringin on hyperglycemia-associated oxidative stress, activation of JNK-1, and CH. Male Sprague-Dawley rats (225-250 g) (n = 7) were divided into 6 groups. Groups I and II were orally treated with distilled water [3.0 mL/kg body weight/day (BW)] and naringin (50 mg/kg BW), respectively. Groups III-VI were rendered diabetic by a single intraperitoneal injection of 65 mg/kg BW of streptozotocin. Groups III, IV, and V were further treated with insulin (4.0 I.U, s.c, twice daily), naringin (50 mg/kg BW), and ramipril (3.0 mg/kg BW), respectively. After 56 days, the animals were sacrificed and then plasma and cardiac tissues obtained for further analysis. Naringin treatment of diabetic rats significantly reversed oxidative stress, lipid peroxidation, proteins oxidation, CH indices, and JNK protein activation compared with untreated diabetic animals. Our results do suggest that naringin mitigates CH by inhibiting oxidative stress leading to inactivation of JNK-1. Naringin supplements could therefore ameliorate CH in diabetic patients.
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PMID:Naringin Mitigates Cardiac Hypertrophy by Reducing Oxidative Stress and Inactivating c-Jun Nuclear Kinase-1 Protein in Type I Diabetes. 2642 21