Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011854 (type 1 diabetes)
 20,749 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is now widely accepted, that the development of type 1 diabetes is based on an autoimmune destruction of the insulin-producing betacells of the pancreas; however, a genetic predisposition is required. 90 to 95% of patients with type 1 diabetes are HLA-DR3 positive and/or HLA-DR4 positive. In addition, recent results from molecular-genetic research suggest an aspartate on position 57 of the HLA-DQ-beta protein, which seems to protect against the autoimmune destruction of the betacell, since it is not found in patients with type 1 diabetes in contrast to control persons. Trigger substances inducing the initial betacell destruction are not known, but might not be necessary according to an actual hypothesis. Finally, all insulin-producing cells are destroyed, and lifelong insulin replacement therapy cannot be circumvented. Prevention of the autoimmune destruction is not possible today; especially, not using immunosuppressive drugs because of side effects.
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PMID:[The pathogenesis of type 1 diabetes mellitus]. 240 78

Trigger finger is a stenosing tenovaginitis in which there is a constriction of the annular sheath associated with a nodule in the digital flexor tendon. Clinically this can present as triggering or snapping of the nodule as it passes through the tight constricting tendon sheath. Although many triggering fingers settle spontaneously, and others respond to local anesthetic and steroid injection, others require surgical decompression. The association between diabetes and trigger finger, although not widely known, has been described and forms part of the "diabetic hand syndrome". We studied 100 adult patients in the group that required surgery. Eighteen of the 100 patients were diabetic with six insulin dependent diabetics (IDDM) and 12 non-insulin dependent diabetics (NIDDM). In the current climate of day case surgery this has significant implications both for the management of known diabetics as well as the preoperative detection of those with the condition.
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PMID:Diabetes and trigger finger. 975 37