Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011854 (type 1 diabetes)
 20,749 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

From September, 1985 to April, 1994, 33 patients underwent surgical repair of corrected transposition of the great arteries associated with other congenital heart anomalies. Of them, 31 patients were SLL type, the other 2 patients were attributed to IDD type. Operations were performed on ventricular septal defect in 28 patients, atrial septal defect in 15, pulmonary stenosis in 29 and two had valvuloplasty for left atrioventricular valve regurgitation, patent ductus arteriosus closure was performed on one and modified Fonton procedure on one. There were five peri-operative deaths being 15.7% of operative morbility; late death was only one patient. The following-up of the survival 27 patients for 2 months to 9 years showed a satisfactory results.
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PMID:Evaluation of surgical effect on cardiovascular anomalies associated with corrected transposition of great arteries. 1006 49

In congenitally corrected transposition (ccTGA) the most common configuration is atrial situs solitus with left ventricular loop and left transposition of the great arteries (SLL). Less common is ccTGA with atrial siti inversus (IDD). In both configurations there is a high incidence of ventricular septal defect, pulmonary stenosis, or atresia and some anatomic abnormality of the morphologic tricuspid valve (mTV). The morphologic right ventricle (mRV) is the systemic ventricle and prone to premature failure, particularly in the presence of early TV regurgitation, atrial arrhythmias conduction defects, and prior surgical ventricular septal defect closure. With a long experience with the Senning operation and then the arterial switch, it seemed feasible that these could be combined in ccTGA to restore the mLV to the systemic circuit. This was first attempted in 1989 by the author and was successful. Many of the more recently graduated congenital heart surgeons have little or no experience with the inflow switch. For this reason, the author was asked to write this article, accenting the technical details of the inflow switch. The author uses the Senning operation, with those modifications needed to accommodate the differences between the morphologic right atrium, conduction system, and quite frequent discordance between the atrial situs and the position of the apex of the heart, in ccTGA as compared with TGA.
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PMID:The double switch operation with accent on the Senning component. 1581 59