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Query: UMLS:C0011854 (type 1 diabetes)
 20,749 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Type 1 diabetes mellitus poses a significant health burden, particularly as a result of its microvascular complications. Clinically evident diabetes-related microvascular complications are extremely rare in childhood and adolescence. However, early functional and structural abnormalities may be present a few years after the onset of the disease. Therefore, regular screening for diabetic microvascular disease, particularly retinopathy and nephropathy, are of foremost importance in paediatric diabetes care. Early detection of diabetic microangiopathy and timely treatment of early signs of these complications have a pivotal role in prevention of blindness and end-stage renal failure in children and adolescents with diabetes.
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PMID:Screening for vascular complications in children and adolescents with type 1 diabetes mellitus. 1197 39

About dollar 1 out of every dollar 7 spent on health care is related to diabetes mellitus, a leading cause of blindness and kidney failure and a strong risk factor for heart disease. Prevalence of the disease has increased by a third among adults in general in the last decade, but intensive therapy has been shown to delay the onset and slow the progression of diabetes-related complications. While insulin therapy remains key in the management of type 1 diabetes, many patients with type 2, or insulin-resistant, diabetes encounter insulin administration errors that compromise the quality of insulin delivery. Insulin errors are a major, but modifiable, barrier to dosing accuracy and optimal diabetes control for many patients. Future trends to combat the problem include increased use of insulin inhalers and smaller doses of rapid- or short-acting insulin to supplement longer-acting injections.
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PMID:Misadventures in insulin therapy: are you at risk? 1265 73

Diabetic retinopathy (DR) is the most frequent complication of diabetes and a leading cause of impaired vision in the Western world. There is general agreement that early diagnosis and treatment of DR can slow its progression and help to prevent blindness. However, as a result of its asymptomatic nature and its etiopathogenesis, which is still unclear due to its multifactorial complexity, DR-related blindness has a growing social impact in industrialized countries. Therefore, in order to gain a better understanding of this serious disease, the author performed an updated 10-year review of risk factors and management of DR in type 1 diabetes.
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PMID:Retinopathy in juvenile diabetes: a 10-year (1990-2000) review. 1501 2

Diabetic retinopathy (DR) is the leading cause of blindness in young adults in the United States. Early identification and treatment of DR can decrease the risk of vision loss in affected patients. This clinical report reviews the risk factors for the development of DR and screening guidance for pediatric patients with type 1 diabetes mellitus.
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PMID:Screening for retinopathy in the pediatric patient with type 1 diabetes mellitus. 1645 86

Diabetic retinopathy (DR) is a microangiopathy, which is caused by chronic hyperglycemia, affecting the retinal arterioles, capillaries and venules, complications of which lead to incurable blindness. Approximately 10% of the diabetic population has type I diabetes mellitus (DM) which is diagnosed before the age of 30 years and rest is type II which is diagnosed after the age of 30 years. In UK 2% general population is affected by DM. In developed countries, diabetic retinopathy is an important and leading cause of blindness in working age group where as in developing western countries this figure occupy 12% of the blindness. In developing countries like Nepal, cataract still remains a main cause of blindness and diabetes is not considered as a major problem. However due to a rapid urbanization and modernization of population, diabetes mellitus is becoming an endemic disease and bringing a new challenge in blindness reduction program.
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PMID:Doctor's role in early detection of diabetic retinopathy and prevention of blindness from its complications. 1615 80

Non Insulin Dependent Diabetes Mellitus is responsible for 60% cases of retinopathy in the population and is one of the common cause of blindness. Oxidative stress as measured by the levels of malondialdehyde, superoxide dismutase (SOD), glutathione peroxidase (GPx) and vitamin C was measured in 50 normal controls, 40 diabetics without complications, 22 diabetics with proliferative and 20 with nonproliferative retinopathy respectively. Our finding suggests that lipid peroxidation increases (P < 0.001) with the increase in severity and duration of diabetes. Antioxidants SOD and vitamin C decrease with the progression of the disease, however GPx tends to increase in the later part of the disease.
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PMID:Lipid peroxidation and antioxidant status in patients with diabetic retinopathy. 1617 Sep 87

Accelerated atherosclerosis and microvascular complications are perhaps the leading cause of coronary heart disease, blindness and renal failure, which could account for disabilities and high mortality rates in patients with diabetes. Several thrombogenic abnormalities have been shown to play a central role in the pathogenesis of these devastating complications. However, the molecular mechanism for thrombogenic diathesis in diabetes is not fully elucidated. A recent clinical study, the Diabetes Control and Complications Trial-Epidemiology of Diabetes Interventions and Complications (DCCT-EDIC) Research, has revealed that the reduction in the risk of progressive retinopathy and nephropathy resulting from intensive therapy in patients with type 1 diabetes persist for at least several years, despite increasing hyperglycemia. Further, intensive therapy during the DCCT resulted in decreased progression of carotid intima-media thickness six years after the end of the trial as well. These clinical studies strongly suggest that so-called 'hyperglycemic memory' causes chronic abnormalities in diabetic vessels that are not easily reversed, even by subsequent, relatively good control of blood glucose. Among various biochemical pathways activated under diabetes, the process of formation and accumulation of advanced glycation end products (AGEs) and their mode of action are most compatible with the theory 'hyperglycemic memory'. In this review, we discuss the role of AGEs in thrombogenic abnormalities in diabetes.
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PMID:Role of advanced glycation end products (AGEs) in thrombogenic abnormalities in diabetes. 1647 28

Retinopathy is the most common microvascular complication of diabetes mellitus, and is an important cause of blindness worldwide. Clinical trials have demonstrated that tight metabolic control inhibits the progression of retinopathy. Good blood pressure control has been shown to be protective in type 2 diabetes, and it may also reduce proliferative retinopathy in type 1 diabetes. However, such control is often difficult to achieve in clinical practice, and may be associated with problems such as hypoglycaemia. New therapies are therefore needed to reduce the risk of retinopathy. There is growing evidence that the renin-angiotensin system (RAS) plays an important role in the pathogenesis of diabetic retinopathy, and this has led to interest in RAS inhibitors as agents to prevent retinopathy. Several trials have suggested that ACE inhibitor therapy can inhibit progression of retinopathy. The Diabetic Retinopathy Candesartan Trials (DIRECT) Programme is currently investigating the effects of the angiotensin II receptor blocker candesartan on the incidence of retinopathy in type 1 diabetes and its progression in type 1 and type 2 diabetes. It is hoped that the results from such large-scale clinical trials will provide more specific information about the medical treatment of diabetic retinopathy.
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PMID:Prospects for angiotensin receptor blockers in diabetic retinopathy. 1732 27

Accelerated atherosclerosis and microvascular complications are perhaps the leading cause of coronary heart disease, blindness and renal failure, which could account for disabilities and high mortality rates in patients with diabetes. Several mechanisms including endothelial cell damage, platelet activation and aggregation, hypercoagulability, and impaired fibrinolysis are involved in the pathogenesis of thrombogenic diathesis in diabetes. However, the underlying molecular mechanism is not fully elucidated. A recent clinical study, the Diabetes Control and Complications Trial-Epidemiology of Diabetes Interventions and Complications (DCCT-EDIC) Research, has revealed that the reduction in the risk of progressive retinopathy and nephropathy resulting from intensive therapy in patients with type 1 diabetes persist for at least several years, despite increasing hyperglycemia. In addition, intensive therapy during the DCCT also reduced the risk of cardiovascular events by about 50 % in type 1 diabetic patients 11 years after the end of the trial. These clinical studies strongly suggest that so-called 'hyperglycemic memory' causes chronic abnormalities in diabetic vessels that are not easily reversed, even by subsequent, relatively good control of blood glucose. Among various biochemical pathways implicated in diabetic vascular complications, the process of formation and accumulation of advanced glycation end products (AGEs) and their mode of action are most compatible with the theory 'hyperglycemic memory'. In this review, we discuss the role of AGEs in thrombogenic abnormalities in diabetes, especially focusing on the deleterious effects of these macroproteins on endothelial cell function, platelet activation and aggregation, coagulation and fibrinolytic systems.
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PMID:Advanced glycation end products (AGEs) and cardiovascular disease (CVD) in diabetes. 1763 Sep 50

Diabetes mellitus continues to be the most common cause of chronic kidney failure, blindness acquired in adulthood, non-traumatic amputations and severe forms of neuropathy. Therefore it is necessary to look for new forms of therapy capable of achieving long-term normalisation of blood sugar levels. The only standard method so far is pancreas transplantation. Most often, it is performed in combination with kidney transplantation and only exceptionally as an isolated procedure. A new and considerably less invasive option is transplantation of isolated Langerhans islets. While the number of pancreas transplantations in IKEM has exceeded 300, the program of islet transplantation is in its formative phase, with 10 clinical surgeries having been performed since May 2007. However, the number of suitable patients who could benefit from this method of treatment largely exceeds the availability of organs suitable for transplantation. Therefore, new possibilities of acquiring insulin producing cell lines are searched for, both from animal tissue and, primarily, from embryonic or adult stem cells. Also the possibility of in vivo regeneration of endogenous or transplanted beta cells of the pancreas has now became an object of study. Combined transplantation of the kidney and pancreas is still the best available method in the treatment of uremic type 1 diabetes patients and its long-term results have shown to be very good, even though their further improvement has been but of a lesser degree. Isolated transplantation of the pancreas is still reserved for a limited group of patients with very labile diabetes. The transplantation of isolated Langerhans isletes is an alternative option which is far safer for the patient, but the long-term results of which still leave much to be desired. The method currently used in the Institute of Clinical and Experimental Medicine (IKEM) is organ transplantation of the pancreas while a program of transplantation of isolated islets has been launched, and also studied are the possibilities of insulin producing cell lines propagation.
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PMID:[Transplantation in the treatment of diabetes]. 1791 31


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