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Query: UMLS:C0011854 (type 1 diabetes)
 20,749 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was to evaluate the caries incidence in a group of young patients with type 1 diabetes mellitus over a 3-year period from the onset of the disease in relation to metabolic control and to caries-associated risk factors. Sixty-four children and adolescents (8-15 years of age) had their diabetes treated and monitored according to a standard medical protocol and received extensive preventive oral health care based on individual needs. Data on blood glucose and glycosylated haemoglobin (Hb A(Ic)) were collected from the medical records. Whole saliva was collected every 3rd month and secretion rate, buffer capacity, glucose concentration, mutans streptococci and lactobacilli counts were determined. Dental examinations, including radiographs, were carried out once a year. Patients with less good metabolic control (>8.0% Hb A(Ic)) exhibited higher glucose levels in resting saliva (p < 0.05) and a significantly higher caries incidence (p < 0.05) compared to those with good metabolic control. The most influential determinants for high caries development during the 3-year follow-up period were metabolic control (odds ratio, OR = 5.7), poor oral hygiene (OR = 6.5), previous caries experience (OR = 5.3) and high levels of salivary lactobacilli (OR = 5.0). The findings suggest that the level of metabolic control and traditional caries risk markers are important factors for caries development in children and adolescents with type 1 diabetes mellitus.
Caries Res
PMID:Caries incidence in young type 1 diabetes mellitus patients in relation to metabolic control and caries-associated risk factors. 1196 27

The aim of this study was to investigate the relationship among type 1 diabetes mellitus, dental caries, and salivary status in children. The study comprised 68, 10-15-yr-old diabetics, and 68, age- and gender-matched non-diabetic controls. Diabetics were categorized into well-to-moderately controlled (HbA1c < 9.0%) and poorly controlled (HbA1c >or= 9.0%) groups. Caries was recorded by assessing lesion activity at non-cavitated and cavity levels. Teeth were examined visually for the presence of dental plaque. Saliva was analyzed for unstimulated and stimulated flow rates, buffer effect, mutans streptococci, lactobacilli, and yeasts. Diabetics had fewer caries and plaque, lower salivary flow rates and buffer effect, and more frequent growth of yeasts than their non-diabetic controls. Well-to-moderately controlled diabetics had fewer decayed surfaces and lower counts of mutans streptococci and yeasts than poorly controlled diabetics, but the level of metabolic control of diabetes had no influence on salivary flow rates and buffer effect. High caries levels in diabetics were significantly associated with age, plaque score, and decreased unstimulated salivary flow rate, but were not associated with the level of metabolic control of diabetes. High caries experience in this study population could be related to plaque accumulation and/or to changes in saliva induced by diabetes mellitus.
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PMID:Dental caries and salivary status in children with type 1 diabetes mellitus, related to the metabolic control of the disease. 1646 Mar 35

The aim of this study was to analyse possible associations between caries increments and selected caries determinants in children with type 1 diabetes mellitus and their age- and sex-matched non-diabetic controls, over 2 years. A total of 63 (10-15 years old) diabetic and non-diabetic pairs were examined for dental caries, oral hygiene and salivary factors. Salivary flow rates, buffer effect, concentrations of mutans streptococci, lactobacilli, yeasts, total IgA and IgG, protein, albumin, amylase and glucose were analysed. Means of 2-year decayed/missing/filled surface (DMFS) increments were similar in diabetics and their controls. Over the study period, both unstimulated and stimulated salivary flow rates remained significantly lower in diabetic children compared to controls. No differences were observed in the counts of lactobacilli, mutans streptococci or yeast growth during follow-up, whereas salivary IgA, protein and glucose concentrations were higher in diabetics than in controls throughout the 2-year period. Multivariable linear regression analysis showed that children with higher 2-year DMFS increments were older at baseline and had higher salivary glucose concentrations than children with lower 2-year DMFS increments. Likewise, higher 2-year DMFS increments in diabetics versus controls were associated with greater increments in salivary glucose concentrations in diabetics. Higher increments in active caries lesions in diabetics versus controls were associated with greater increments of dental plaque and greater increments of salivary albumin. Our results suggest that, in addition to dental plaque as a common caries risk factor, diabetes-induced changes in salivary glucose and albumin concentrations are indicative of caries development among diabetics.
Caries Res 2008
PMID:Dental caries increments and related factors in children with type 1 diabetes mellitus. 1872 67

Data sources PubMed, EMBASE and China National Knowledge Infrastructure. Manual review of reference list of included studies.Study selection Cross-sectional studies or the first evaluation of longitudinal studies that were conducted on patients (<18 years old) with a known diagnosis of type 1 diabetes mellitus (DM). The primary outcome was prevalence of dental caries.Data extraction and synthesis Selection of studies, data extraction and risk of bias assessment was performed, independently, by two members of the review team. Inter-rater reliability (kappa = 0.68) was provided. Disagreements were resolved by consensus. The modified Newcastle-Ottawa scale, modified specifically to this review, was used to assess study quality and bias. Where appropriate, data was pooled and analysed using a random-effects model. Subgroup analyses were carried out where possible.Results Four hundred and eighty-eight potential articles were screened; 83 full-text articles were reviewed, with ten (involving a total of 538 patients) included in the meta-analysis. Seven studies were adjudged to be of high quality and three of low quality using the modified Newcastle-Ottawa scale. Overall, pooled prevalence of dental caries, among children and adolescents with type 1 DM, was 67% (95%CI: 0.56-0.77%; I2 = 83%; p<0.01). Subgroup analyses (geographic location and diabetic control) highlighted pooled prevalence was highest at 84% (95%CI: 0.67-0.94%; I2 = 49%; p = 0.16) in South America and 66% (95%CI: 0.43-0.83%; I2 = 87%; p<0.01) in those with bad diabetic control.Conclusions Caries prevalence is high among children and adolescents with type 1 DM. Diabetic children and adolescents need to be regularly screened for dental disease. Consistent preventive measures are required, from all healthcare professionals involved in the care of these patients, to ensure a balance in struck between optimum oral health and diabetic control for these patients.
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PMID:Children with type 1 diabetes and caries - are they linked? 3152 Nov 52