Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011854 (type 1 diabetes)
 20,749 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty-seven non-IDDM patients at an early stage of polyneuropathy, defined as the presence of symptoms for less than two years, as well as an abnormal perception threshold and/or abnormal thermal discrimination threshold, were treated with sabeluzole, a new antihypoxic drug, or placebo for 1 year in a double-blind, placebo-controlled study. They were examined neurophysiologically every 3 months, when motor (tibial, ulnar) nerve and sensory (sural, ulnar) nerve conduction velocities, H-reflex of the soleus muscle, SF-EMG of the anterior tibial muscle, static and dynamic pupillometry were measured. Statistical analysis did not show significant differences in nerve function between the sabeluzole group and the placebo group. There were also no significant changes within each group over the 1-year period. The results of the present study show no beneficial effect of sabeluzole on peripheral nerve function in patients at an early stage of diabetic polyneuropathy.
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PMID:Antihypoxic treatment at an early stage of diabetic neuropathy: an electrophysiological study with sabeluzole. 829 40

To investigate whether pain and paresthesias could identify two different subclasses of small-fibre diabetic neuropathy, and to evaluate their relation to the metabolic control, we tested nerve conduction velocity (NCV) of median nerve (sensitive-SM, and motor-MM) and deep peroneal nerve (DP) in 48 diabetics (24 IDDM, 24 NIDDM) reporting pain (group A) or paresthesias (group B) that might be due to diabetic polyneuropathy. Glycated haemoglobin (HbA1c) was also assessed. No difference between group A and group B was found either in NCV, in all nerves tested, or in HbA1c. No relation was observed between NCV of nerves tested and HbA1c, duration of diabetes, age and type of diabetes in both groups.
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PMID:Neuroelectric procedure does not discriminate between painful and paresthetic diabetic neuropathy. 273 2

Of 208 young women with insulin dependent diabetes, 15 (7%) had a clinically apparent eating disorder (anorexia nervosa or bulimia), a much higher prevalence than reported in non-diabetic women. Most, but not all, of these patients had a long history of poor glycaemic control. In contrast with previous suggestions, control did not deteriorate after the onset of the eating disorder. There was a high incidence and an early onset of diabetic complications. Eleven of the 15 patients had retinopathy, six with proliferative changes; six had nephropathy; and six neuropathy. Most strikingly, four patients with anorexia nervosa developed acute painful polyneuropathy. In each case pain started when the eating disorder developed, almost coinciding with the peak of weight reduction. Remission of pain occurred as weight was regained. The symptoms were accompanied by abnormalities in peripheral nerve electrophysiology and autonomic nerve function, some improvements in which accompanied weight recovery. It is suggested that nutritional factors may contribute to the high rate of early onset diabetic complications, particularly neuropathy.
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PMID:Clinically apparent eating disorders in young diabetic women: associations with painful neuropathy and other complications. 310 77

The results of allogeneic clinical islet cell transplantation continue to be rather disappointing. However, results of clinical pancreatic transplantation in Type-I-diabetes are still improving: some centres (incl. the Munich centre) have reported a 1-year-graft survival rate of more than 70%. In 60-65% of successfully transplanted patients a normalisation of glucose tolerance can be achieved. There is accumulating evidence suggesting that successful pancreatic transplantation exerts a curative effect in Type I diabetes mellitus: Long term investigations have shown a subjective and objective improvement of diabetic retinopathy, nephropathy, polyneuropathy and peripheral microangiopathy.
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PMID:[Status of pancreatic organ and pancreatic islet cell transplantation]. 312 22

The time course of the blood level of C-peptide was studied in 20 patients with insulin dependent diabetes mellitus in the course of 1 year after human fetal pancreatic islet cell allotransplantation. All the recipients suffered from a labile type of diabetes complicated by polyneuropathy, glomerulosclerosis and progressive retinopathy. C-peptide concentration was determined by a radioimmunoassay using Behring-Werke AE kits (FRG). The recipient were divided into 3 groups with relation to the preoperative level of C-peptidemia (with a low level 0.17 +/- 0.06 ng/ml, a mean level 0.9 +/- 0.11 ng/ml and a high level 3.07 +/- 0.24 ng/ml). One-two days before cell culture allotransplantation the mean concentration of C-peptide was 0.3 +/- 0.02 ng/ml. One-two weeks after transplantation it rose up to 0.89 +/- 0.11 ng/ml (p less than 0.01), by the end of the 1st month it reached 2.85 +/- 0.54 ng/ml, in 2-3 months it was lowered up to 1.98 +/- 0.21 ng/ml and remained at this level in the next months decreasing up to 1.4 +/- 0.36 ng/ml and approximated the preoperative levels by the end of the year. The same time course was noted in all 3 groups irrespective of the preoperative levels and differed in quantitative indices only. Stabilization of a course of disease, normalization of some biochemical indices, disappearance or weakening of a degree of concomitant symptoms and a decrease in an exogenous dose of insulin were noted.
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PMID:[Changes in the C-peptide concentration in the blood of patients with diabetes mellitus after the transplantation of cultures of pancreatic islet cells]. 314 6

The clinical and electro-neurographic examinations were carried out in 54 patients aged 21-67 years (mean = 41.8) with IDDM of at least 10-year duration, and 25 subjects aged 19-62 years (mean = 39.0) as a control group. The aim of the study was the determination of: 1) the frequency of polyneuropathy appearance in patients with IDDM of at least 10-year duration; 2) the usefulness of electroneurography for detection of subclinical impairment of peripheral nervous system in diabetics; 3) the characterization of electro-neurographic abnormalities in diabetic neuropathy; 4) the influence of diabetes duration and metabolic control on severity of peripheral nerves affection; 5) the relationship between polyneuropathy and retinopathy, nephropathy and cataract occurrence in diabetic patients. Polyneuropathy was diagnosed--clinically in 67% of patients, electro-neurographically in 85% of patients. The neurographic study proved high sensitivity for detection of subclinical affection of peripheral nerves in diabetics. The electro-neurographic abnormalities appeared more frequently and were more considerable in the group of patients with clinical polyneuropathy. Frequency of the sensory and motor nerve fibres involvement was similar. The electroneurographical abnormalities corresponded with the features of mixed--axonal and demyelinating type of neuropathy. It was disclosed that the degree of neurographical changes did not depend on duration and severity of hyperglycemia in late period of the disease. A moderate relationship between occurrence of polyneuropathy and retinopathy, nephropathy as well as diabetic cataract was revealed.
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PMID:[Clinical and electroneurographic changes in the peripheral nervous system of patients with chronic insulin-dependent diabetes (IDDM)]. 750 45

In 137 patients with insulin dependent diabetes mellitus (74 men and 63 women) aged from 16 to 60 years 193 operations were done, including 148 xenografts of cryopreserved cells of pancreatic islets and 45 deportalizations of pancreatic blood flow using the distal venous splenorenal anastomosis formation. Pronounced antidiabetic effect of both operations was observed, justified by metabolic compensation of diabetes mellitus, lowering of given insulin dose, stabilization of chronic diabetic microangiopathy and polyneuropathy course. Complex approach to the surgical treatment of diabetes mellitus comprises the performance of repeated or multiple transplantations of pancreatic islets cells as well as (what is more expedient) its gradual application in combination with the pancreatic blood flow deportalization. Stationary and regional banks of cryopreserved cells of pancreatic islets were founded.
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PMID:[Combination of the deportalization of pancreatic blood flow and transplantation of pancreatic islets in patients with insulin dependent diabetes mellitus]. 765 73

In order to determine the possible influence of C-peptide on nerve function, 12 insulin-dependent diabetic (IDDM) patients with symptoms of diabetic polyneuropathy were studied twice under euglycaemic conditions. Tests of autonomic nerve function (respiratory heart rate variability, acceleration and brake index during tilting), quantitative sensory threshold determinations, nerve conduction studies and clinical neurological examination were carried out before and during a 3-h i.v. infusion of either C-peptide (6 pmol.kg-1.min-1) or physiological saline solution in a double-blind study. Plasma C-peptide concentrations increased from 0.11 +/- 0.02 to 1.73 +/- 0.04 nmol/l during C-peptide infusion. Clinical neurological examination quantitative sensory threshold evaluations and nerve conduction measurements failed to detect significant changes between C-peptide and saline study periods. Respiratory heart rate variability increased significantly from 13 +/- 1 to 20 +/- 2% during C-peptide infusion (p < 0.001), reaching normal values in five of the subjects; control studies with saline infusion did not alter the heart rate variability (basal, 14 +/- 2; saline, 15 +/- 2%). A reduced brake index value was found in seven patients and increased significantly during the C-peptide infusion period (4.6 +/- 1.0 to 10.3 +/- 2.2%, p < 0.05) but not during saline infusion (5.9 +/- 2 to 4.1 +/- 1.1%, NS). It is concluded that short-term (3-h) infusion of C-peptide in physiological amounts may improve autonomic nerve function in patients with IDDM.
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PMID:C-peptide improves autonomic nerve function in IDDM patients. 878 64

The pathogeneses of diabetic neuropathy is still unclear. This study prospectively investigated the risk factors for distal symmetrical polyneuropathy (DSP) in a cohort of childhood-onset IDDM patients. Subjects from the Epidemiology of Diabetes Complications (EDC) Study were clinically examined at baseline and then biennially. DSP was diagnosed by a combination of clinical criteria, symptoms and signs (Diabetes Control and Complications Trial [DCCT] exam), and quantitative sensory threshold (QST). Among the 463 (70.4%) subjects who were free of DSP at baseline, 453 (97.8%) participated in at least one biennial reexamination during the first 6 years of follow-up and were included in the current analysis. A total of 68 (15.0%) subjects developed DSP in 6 years, giving a cumulative probability of 0.29. The Cox proportional hazards model shows that longer IDDM duration, hypertension, poor glycemic control, height, and smoking were all independent predictors of the incidence of DSP (all P < 0.0001, except for smoking for which P = 0.03). Hypertension showed the greatest impact on the development of DSP for individuals with either short or long IDDM duration. This study confirms some risk factors for DSP found in cross-sectional studies and suggests a strong relationship between hypertension and DSP. The results indicate that in addition to good glycemic control, avoidance of smoking and good blood pressure control may be helpful in preventing or delaying the onset of DSP in IDDM patients.
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PMID:Hypertension as a risk factor for diabetic neuropathy: a prospective study. 907 9

Diabetic polyneuropathy is a common, disabling chronic complication of diabetes mellitus. Previous studies have suggested that combined pancreas-kidney transplantation can ameliorate nerve conduction. The relative contribution of the correction of hyperglycaemia and uraemia on nerve function is still a matter of debate. Nerve conduction velocity (NCV) was assessed before and after simultaneous pancreas and kidney transplantation, and before and after pancreas graft failure in five insulin-dependent diabetic (IDDM) patients affected by severe diabetic polyneuropathy. Sensory and motor NCV were recorded in five nerves and expressed as a cumulative index for each patient. Metabolic control was evaluated by fasting blood glucose and glycosylated haemoglobin levels. NCV index was below normal values before transplant: -3.8 +/- 0.7 (normal value: 0.89), improved 1 and 2 years after transplant: -3.1 +/- 1.3 and -2.6 +/- 0.9 (p = 0.0019), stabilised until pancreas failure and deteriorated to pre-transplant values 2 years after pancreas graft failure: -3.6 +/- 1.0 (p = 0.034). Fasting blood glucose levels worsened after pancreas graft failure. HbA1c levels, in the normal range during functioning pancreas graft (6.6 +/- 0.6%), deteriorated after its failure (8.0 +/- 0.6%, p = 0.04). Kidney function was preserved. These data support a positive effect of pancreas transplantation per se on NCV in IDDM subjects with diabetic polyneuropathy, thus demonstrating that metabolic control provided by a self-regulated source of insulin not only halts but also ameliorates nerve function, even if polyneuropathy is advanced.
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PMID:Amelioration of nerve conduction velocity following simultaneous kidney/pancreas transplantation is due to the glycaemic control provided by the pancreas. 930 Feb 50


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