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Query: UMLS:C0011854 (type 1 diabetes)
 20,749 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Several malformations and malformation complexes have been alleged to be associated with maternal type 1 diabetes mellitus: in particular, sacral dysplasia, caudal regression/sirenomelia, femoral dysplasia, and holoprosencephaly. For some of the malformations the claim rests on case material, and for others on theoretical considerations. The history and evolution of these ideas are presented.
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PMID:Case reports of malformations associated with maternal diabetes: history and critique. 833 Apr 51

The clinical features of a fetus with sirenomelia, limb reduction defects, cardiovascular malformation and renal agenesis are reported. The mother of the child suffers from insulin dependent diabetes. The limb, cardiac and renal abnormalities are well recognized sequelae of diabetic pregnancies. The association of sirenomelia and maternal diabetes is somewhat controversial. The link between caudal regression syndrome, sirenomelia and maternal diabetes will be discussed.
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PMID:Sirenomelia, limb reduction defects, cardiovascular malformation, renal agenesis in an infant born to a diabetic mother. 901 22

Sacral agenesis (part of the caudal regression syndrome) is a rare and severe sacral developmental abnormality. It is a congenital malformation of unknown aetiology with possible involvement of genetic and teratogenic factors. It is described by various degrees of developmental failure, the most extreme and rare being sirenomelia or mermaid syndrome. The associated malformations comprise anorectal, vertebral, urological, genital, and lower limb anomalies. Approximately 15-20% mothers of these children have insulin dependent diabetes mellitus. The case is being reported for its rarity and educative value because prognosis is good in isolated sacral agenesis.
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PMID:Sacral Agenesis with Neurogenic Bladder Dysfunction-A Case Report and Review of the Literature. 2626 74