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Query: UMLS:C0011854 (type 1 diabetes)
 20,749 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The influence of diabetes on leg blood flow in intermittent claudication has been assessed by comparing the systolic arm-ankle pressure gradient at rest and resistance to blood flow during reactive hyperemia in patients with non-insulin dependent diabetes and non-diabetic controls. Cases and controls were matched for age and sex. Smoking habits, blood pressure, and blood lipids didn't differ in the two groups. Diabetes was associated with a higher resistance to blood flow during reactive hyperemia and a greater arm-ankle pressure gradient at rest. Resistance to blood flow during reactive hyperemia was in the non-diabetics strongly correlated to the arm-ankle pressure gradient at rest (r = 0.84). Corresponding correlation coefficient was in diabetics 0.04. In one of four diabetic legs a high resistance to blood flow during reactive hyperemia didn't correspond to a big arm-ankle pressure gradient. The results in this study support the concept of both macro- and microvascular disease in diabetes.
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PMID:Leg blood flow in intermittent claudication--a comparison between non insulin dependent diabetics and non diabetics. 649 53

Considerable knowledge has accumulated in recent decades concerning the significance of physical activity in the treatment of a number of diseases, including diseases that do not primarily manifest as disorders of the locomotive apparatus. In this review we present the evidence for prescribing exercise therapy in the treatment of metabolic syndrome-related disorders (insulin resistance, type 2 diabetes, dyslipidemia, hypertension, obesity), heart and pulmonary diseases (chronic obstructive pulmonary disease, coronary heart disease, chronic heart failure, intermittent claudication), muscle, bone and joint diseases (osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, chronic fatigue syndrome) and cancer, depression, asthma and type 1 diabetes. For each disease, we review the effect of exercise therapy on disease pathogenesis, on symptoms specific to the diagnosis, on physical fitness or strength and on quality of life. The possible mechanisms of action are briefly examined and the principles for prescribing exercise therapy are discussed, focusing on the type and amount of exercise and possible contraindications.
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PMID:Evidence for prescribing exercise as therapy in chronic disease. 1664 91

The development of autonomic nervous dysfunction (AND) in subjects with diabetes influences life expectancy and may cause sudden death. The present study evaluates disturbances of AND in 41 men with type 1 diabetes mellitus, but without heart symptoms, and the relationship with other long term diabetic complications and blood sugar control. Their age ranged 18-50 years (mean 34 +/-8 years) and the duration of diabetes 1-43 years (mean 13 +/-10 years). A control group consisted of 18 healthy men of similar age. Heart rate and blood pressure responses during standard autonomic tests were assessed by a computer program, vibration sensibility by a Biothesiometer, and an exercise test was performed. AND was more frequent in diabetics than controls (39% versus 6%, p<0.01), and increased with the duration of diabetes (r=0.34, p<0.05), but not significantly with HbAl-levels (r=0.21, p=0.19). Diabetics with AND had an earlier onset p<0.05) and a longer duration of (p<0.01) diabetes, decreased vibration sense (p<0.05), more frequent hypoglycaemic episodes (p<0.05), intermittent claudication (p<0.01), a higher resting heart rate (p<0.05), and a shorter treadmill time (p<0.05). Consequently, at maximal exercise their systolic (p<0.05) and diastolic (p=0.08) blood pressure increased less. With longer duration of diabetes, retinopathy (p<p.001), vibration sense p<0.05), and AND (p<0.05) all worsened. The same held for a total score of nervous, eye and kidney complications (r=0.75, p<0.001), which however was not related to HbAl values. In conclusion, type 1 diabetics often have disturbances of the autonomic and peripheral nervous system that may be without symptoms and increase with the duration of diabetes.
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PMID:[Autonomic nervous dysfunction in insulin-dependent (type 1) diabetic men.]. 2006 85