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Query: UMLS:C0011854 (type 1 diabetes)
 20,749 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The prevalence of diabetes mellitus in the family history of 371 patients with primary glaucoma--closed-angle glaucoma, ocular hypertension and open-angle glaucoma--and 85 age- and sex-matched control subjects was determined. There was a significantly-increased prevalence of familial type 2 diabetes mellitus (non-insulin dependent diabetes mellitus) in patients with closed-angle glaucoma (p = 0.004) and ocular hypertension (p = 0.02). Primary glaucoma was not associated with familial type 1 diabetes mellitus (insulin dependent diabetes mellitus). The implications are discussed.
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PMID:The prevalence of diabetes mellitus in the family history of patients with primary glaucoma. 395 66

The prevalence of glaucoma and ocular hypertension was investigated in an epidemiological study of diabetics traced by registration of prescriptions on insulin and oral hypoglycaemic agents (OHA) on the island of Falster (inhabitants 44 498), Denmark. Among 533 diabetics (227 insulin- and 306 OHA-treated) the prevalence rate of primary open angle glaucoma and ocular hypertension was 6.0% and 3.0%, respectively. Neovascular glaucoma occurred in 2.1% of all diabetics and in 21.3% of diabetics with proliferative retinopathy. Open angle glaucoma was more prevalent (P less than 0.01) in type 2 diabetes mellitus compared with type 1 diabetes mellitus. No difference in the prevalence of neovascular glaucoma was found between type 1 and type 2 diabetics. The occurrence of open angle glaucoma correlated positively (P less than 0.01) to the current age (greater than 65 years) in both groups and the diabetes onset age (greater than 40 years) in insulin-treated diabetics. Neovascular glaucoma correlated positively (P less than 0.05) with diabetic macrovascular complications in total (myocardial infarction, ischemic heart disease, arterial hypertension, cerebrovascular stroke, gangrene/amputation), neuropathy and severe microvascular complications (proliferative retinopathy, retinovascular occlusion). Diabetics with open angle glaucoma and ocular hypertension showed a higher frequency (P less than 0.05) of ischemic heart disease, arterial hypertension and retinovascular occlusion compared with diabetics without glaucoma or ocular hypertension.
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PMID:The prevalence of glaucoma and ocular hypertension in type 1 and 2 diabetes mellitus. An epidemiological study of diabetes mellitus on the island of Falster, Denmark. 663 28

Predictive medicine is based on the early recognition of a pathologic process before the onset of clinical manifestations, followed by preventive therapy. Prediction can be achieved by identifying disease predisposing genes. However, this approach is usually insufficient because most often the disease is polygenic and the penetrance of genetic factors is incomplete, which reduces the reliability of the prediction. It is very useful when it is possible to complement this prediction by the study of biological markers allowing the detection of the triggering of the pathogenic process, before it has induced significant lesions or functional disturbances at the origin of clinical manifestations. Predictive medicine is only justified when it may lead to preventive therapy as in the exemplary case of juvenile glaucoma. The case of insulin dependent diabetes mellitus is also interesting, even if preventive therapy is not yet routinely available.
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PMID:[Predictive medicine]. 896 55

The medical literature of the last decade enables us to estimate survival of diabetics. Insulin dependent diabetic (IDDM) present a 3 to 6-fold mortality and die after age 30, the most frequent causes being end stage renal and vascular diseases. Non insulin-dependent diabetic (NIDDM) mortality is 1.4 to 3.7 times that of non-diabetics. Cardiovascular events and strokes are the major causes of death. Pancreatic carcinoma occurs twice as frequently in NIDDM compared to non-diabetics. Early markers of late severe complications are hypertension and proteinuria. Retinopathy has little influence on morality if other risk factors are considered. Yet, glaucoma and lens changes are associated with three- and twofold mortalities. One of five IDDM with microalbuminuria progresses to overt nephropathy in 5 years. In NIDDM micro-albuminuria predicts cardiovascular disease with a mortality of up to 2 times. Careful treatment of cardiovascular risk factors and of microalbuminuria combined with optimal metabolic control substantially reduces mortality of diabetics.
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PMID:Diabetes mellitus--long time survival. 1018 35

We present here two DIDMOAD syndrome cases (Diabetes Mellitus, Diabetes Insipidus, Optic Atrophy, Deafness) in a Turkish family. In the examination of the propositus who had consanguineous parents, diabetes mellitus, diabetes insipidus, optic atrophy, and deafness were observed in addition to myopia, juvenile glaucoma, posterior polar cataract, and dilatation of the urinary tract. Diabetes mellitus, diabetes inspidus, optic atrophy, deafness, myopia, and ventricular septal defect were observed in his elder brother. Juvenile onset diabetes mellitus, congenital glaucoma, deafness, and heart disease were the other remarkable findings observed in relatives to this family. Juvenile glaucoma, posterior polar cataract observed in our propositus, and myopia in both our DIDMOAD syndrome cases are the first ophthalmic manifestations described in the DIDMOAD syndrome.
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PMID:A DIDMOAD syndrome family with juvenile glaucoma and myopia findings. 1099 58

We evaluated morphological changes in several pathologies using computerized videocapillaroscopy, and related hemorheological patterns using the laser assisted optical rotational red cell analyzer (LORCA). In addition, tissue oxygenation was measured using two oximeters with Combi sensors (Periflux 5000, Perimed). The study included four groups of patients (pts) that were compared with a control group. Group A Controls (n=25: 15 males [M] and 10 females [F] aged 36 +/- 3 years); Group B Diabetic pts n=32 (IDDM pts n=20: 12 M and 8 F aged 43 +/- 4 years; NIDDM pts n=12: 6 M and 6 F aged 45 +/- 3 years); Group C Glaucoma pts n=30 (16 M and 14 F aged 42 +/- 5 years); Group D Liver failure pts n=6 (3 M and 3 F aged 44 +/- 5 years); Group E Hypertensive pts n=50 (smokers n=28: 12 M and 16 F aged 40 +/- 4 years, and nonsmokers n=22: 12 M and 10 F aged 38 +/- 3 years). In all patients hemorheological measurements were made using the LORCA (including red blood cell [RBC] deformability and aggregability), morphology was evaluated using computerized videocapillaroscopy (magnification 200 x), and transcutaneous oxygen partial pressure measurements (TcpO2) were made with the Periflux 5000. In patients with diabetic microangiopathy: the capillary loops in 50% (16/32) of these pts showed formations such as 'deer horns', 72% (23/32) showed formations such as 'elephant nose', and in 45% (14/32) formations such as a 'cork screw'; in diabetics with POAD an important capillary rarefaction was found in 26% (9/32) of the pts. In glaucoma patients, in 84% (25/30) we observed 'capillary meandering' and images such as 'a comb'. In patients with more complicated pathology capillary rarefaction was found in 70% (21/30) of the patients. An improvement in the perfusion of non-functional loops was found in deceased patients who had suffered liver failure one week after liver transplantation in 90% (5/6) of the studied cadavers. In non-smoking hypertensives morphological changes were found in 25% (6/22) of the patients, and in hypertensive smokers in 47% (13/28). RBC deformability was detected using LORCA and expressed as the Elongation Index (EI), and RBC aggregability was detected using LORCA and expressed in t 1/2 (seconds) indicating the RBC aggregability peak. Group A controls: EI 0.59 +/- 0.02; t 1/2 3 +/- 1 sec; Group B: IDDM EI 0.55 +/- 0.01; t 1/2 : 2 +/- 0.5 sec p < 0.05; NIDDM EI 0.56 +/- 0.01; t 1/2 2 +/- 0.2 sec p < 0.04; Group C glaucoma: EI 0.56 +/- 0.01; t 1/2 2 +/- 0.3 sec p < 0.05; Group D liver failure: EI 0.56 0.02; t 1/2 2 +/- 0.4 sec p < 0.03; Group E hypertensives: smokers EI 0.56 +/- 0.02; t 1/2 2 +/- 0.6 sec p < 0.04; non-smokers EI 0.57 +/- 0.02; t 1/2 2 +/- 0.6 sec p < 0.04 compared with controls. We also measured the TcpO2 at the dorsum of the right foot as a standard site representing peripheral control of microvasculature perfusion. Group A 96 +/- 11 mmHg; Group B IDDM 74 +/- 9 mmHg p < 0.05; NIDDM 76 +/- 8 mmHg p < 0.05; Group C glaucoma 75 +/- 9 mmHg p < 0.05; Group D liver failure 69 +/- 6 mmHg p < 0.05; Group E hypertensives: smokers 70 +/- 5 mmHg p < 0.05, non-smokers 77 +/- 9 mmHg p < 0.05 compared with controls. This study presents an interesting and complete methodology to evaluate the microcirculation in different pathologies that induce changes in the microvasculature.
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PMID:Hemorheological aspects in the microvasculature of several pathologies. 1772 41

The authors present a rare case of acute bilateral cataract with phacomorphic glaucoma in a girl with newly diagnosed type 1 diabetes mellitus without a known history of ocular problems. Within 3 months after the diagnosis of diabetes mellitus, she presented with high intraocular pressure. Her visual acuity was limited to hand motions. The patient required immediate surgical intervention. Postoperatively, the intraocular pressure normalized and bilateral visual acuity was 6/6.
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PMID:Acute bilateral cataract with phacomorphic glaucoma in a girl with newly diagnosed type 1 diabetes mellitus. 2115 59

The variables such as race, skin colour and ethnicity have become intensely discussed in medicine research, as a response to the rising debate over the importance of the ethnic-racial dimension in the scope of health-disease processes. The aim of this study was to identify the European (EUR), African (AFR) and Amerindian (AMR) ancestries on Brazilian health outcomes through a systematic literature review. This study was carried out by searching in three electronic databases, for studies published between 2005 and 2017. A total of 13 papers were eligible. The search identified the following health outcomes: visceral leishmaniosis, malaria, Alzheimer's disease, neuromyelitis optica, multiple sclerosis, prostate cancer, non-syndromic cleft lip/palate, chronic heart failure, sickle cell disease, primary congenital glaucoma, preterm labour, preterm premature rupture of membranes, systemic lupus erythematosus and type 1 diabetes mellitus. Research paper assessments were guided by the STROBE instrument, and agreements between results were determined by comparing the points attributed by two authors. Increased EUR ancestry was identified from preterm labour (PTL), type 1 diabetes (T1D) and non-syndromic cleft lip with or without cleft palate (NSCL), as well as in patients presenting aggressive prostate cancer prognoses. On the other hand, the highest AFR ancestral component was verified from systemic lupus erythematosus (SLE) and primary congenital glaucoma (PCG) cases, presenting worse prognoses. AMR ancestry may be a protective factor in the development of Alzheimer's disease (AD). The worst hemodynamic parameters in cases of heart failure (HF) were identified among individuals with greater AMR and AFR ancestry indices.
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PMID:A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes. 3235 9

Objective: This study examined the full spectrum of comorbid disorders in all statutory-health-insured children aged 5 to 14 years with ADHD in 2017 by using nationwide claims data in Germany. Method: Children with ADHD (n = 258,662) were compared for the presence of 864 comorbid diseases with a control group matched by gender, age, and region of residence (n = 2,327,958). Results: Among others, metabolic disorders (odds ratio [OR] = 9.18; 95% confidence interval [CI] = [8.43, 9.99]), viral pneumonia (OR = 4.95; 95% CI = [2.37, 10.33]), disorders of white blood cells (OR = 4.55; 95% CI = [3.83, 5.40]), kidney failure (OR = 3.33; 95% CI = [2.65, 4.18]), hypertension (OR = 3.26; 95% CI = [3.00, 3.55]), obesity (OR = 2.85; 95% CI = [2.80, 2.91]), type 2 diabetes (OR = 2.61; 95% CI = [2.11, 3.23]), migraine (OR = 2.49; 95% CI = [2.37, 2.61]), asthma (OR = 2.19; 95% CI = [2.16, 2.22]), atopic dermatitis (OR = 2.10; 95% CI = [2.16, 2.23]), juvenile arthritis (OR = 1.56; 95% CI = [1.39, 1.76]), glaucoma (OR = 1.51; 95% CI = [1.30, 1.75]), and type 1 diabetes (OR = 1.30; 95% CI = [1.20, 1.40]) were more likely to be diagnosed in ADHD children. Conclusion: Along with psychiatric diseases, various somatic diseases were more common in ADHD children. The results have direct implications for patient care, including fine-grained diagnostics and personalized therapy.
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PMID:Psychiatric and Nonpsychiatric Comorbidities Among Children With ADHD: An Exploratory Analysis of Nationwide Claims Data in Germany. 3136 81