Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011854 (type 1 diabetes)
 20,749 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 14-year-old female with insulin dependent diabetes mellitus for 3 months, suddenly developed - in less than one day - a dense 'snow-flake cataract' with severe visual impairment in the left eye. In hospital, 5 days later one morning, the patient experienced additional loss of vision in the right eye due to further rapid cataract development, in close relation to hypoglycaemia in the early morning. In another case, a 22-year-old diabetic woman, treated with insulin for 1 year, developed an acute diabetic cataract in less than one day with pronounced visual reduction. Previously, only a few cases of acutely developed and irreversible diabetic cataract have been published. The prevalence of this rare type of diabetic cataract is estimated to be below 1% among diabetics.
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PMID:Two cases of acutely developed cataract in diabetes mellitus. 646 86

The clinical and electro-neurographic examinations were carried out in 54 patients aged 21-67 years (mean = 41.8) with IDDM of at least 10-year duration, and 25 subjects aged 19-62 years (mean = 39.0) as a control group. The aim of the study was the determination of: 1) the frequency of polyneuropathy appearance in patients with IDDM of at least 10-year duration; 2) the usefulness of electroneurography for detection of subclinical impairment of peripheral nervous system in diabetics; 3) the characterization of electro-neurographic abnormalities in diabetic neuropathy; 4) the influence of diabetes duration and metabolic control on severity of peripheral nerves affection; 5) the relationship between polyneuropathy and retinopathy, nephropathy and cataract occurrence in diabetic patients. Polyneuropathy was diagnosed--clinically in 67% of patients, electro-neurographically in 85% of patients. The neurographic study proved high sensitivity for detection of subclinical affection of peripheral nerves in diabetics. The electro-neurographic abnormalities appeared more frequently and were more considerable in the group of patients with clinical polyneuropathy. Frequency of the sensory and motor nerve fibres involvement was similar. The electroneurographical abnormalities corresponded with the features of mixed--axonal and demyelinating type of neuropathy. It was disclosed that the degree of neurographical changes did not depend on duration and severity of hyperglycemia in late period of the disease. A moderate relationship between occurrence of polyneuropathy and retinopathy, nephropathy as well as diabetic cataract was revealed.
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PMID:[Clinical and electroneurographic changes in the peripheral nervous system of patients with chronic insulin-dependent diabetes (IDDM)]. 750 45

The morphologically distinct diabetic or 'metabolic' cataract is rare in newly diagnosed insulin dependent diabetes. The cases described are of five adolescents (three girls, two boys) with newly diagnosed insulin dependent diabetes who developed metabolic cataracts close to the time of diagnosis (0-16 months). They all had a prolonged duration of symptoms before diagnosis (4-24 months) and high glycated haemoglobin levels at diagnosis (15-21%). The pathogenesis of diabetic cataract is not well understood in humans. An attempt is made to link clinical observations with evidence from experimental animal models to understand the mechanism of cataract formation, with particular reference to the aldose reductase pathway. It is recommended that the lens and retina are examined at the onset of diabetes in all children, especially those who have a prolonged duration of symptoms before diagnosis and who report persistent blurred vision.
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PMID:Metabolic cataracts in newly diagnosed diabetes. 906 99

A 14-year-old girl presented with cataract as an initial sign of IDDM. Before the diagnosis of DM, she showed no acute symptoms, including ketoacidosis. Retrospectively, there had been faint signs of polyuria, polydipsia, and nycturia. Diabetic cataract is a rare complication in young diabetics and is usually associated with long-standing DM and poor metabolic control. Previous cases have a striking resemblance to our patient, thus suggesting that a small group of young diabetics have weak symptoms, but are nevertheless at great risk of developing diabetic complications.
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PMID:[Cataract--an initial symptom of diabetes mellitus in a 14-year old girl]. 1160 Nov 24