Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011854 (type 1 diabetes)
 20,749 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

19 IDDM patients (m/f 9/10; ages 7-25 y.; duration of diabetes 3-20 y., mean 10 y.) have been compared to 15 healthy controls (m/f 11/4; ages 11-24 y., mean 14 y.) in respect to HRTS (heart rate response to standing), SDB (single deep breath) and Valsalva maneuvre. In the diabetics the results have been correlated to MNCV (motor nerve conduction velocities), quality of diabetic control and duration of diabetes. A questionnaire did not uncover signs or symptoms of autonomic dysfunction. Resting heart rates were significantly higher in diabetics but were unrelated to age, duration of diabetes, quality of diabetic control or MNCV. HRTS, SDB and the Valsalva maneuvre did not display statistically significant differences between diabetics and controls. Diabetic autonomic dysfunction seems to be rare in young diabetics. Routinely testing for this sequela would therefore not be justified at this stage of diabetes. On the other hand diabetic autonomic dysfunction might be harmful for the patient as regards sudden and unexpected cardiorespiratory arrest eg. during anaesthesia or bronchopneumonia. If therefore symptoms and/or signs of possible peripheral or autonomic dysfunction are present special investigations (eg. HRTS) are indicated.
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PMID:[Function of the autonomic nervous system in children and adolescents with insulin-dependent diabetes mellitus]. 634 18

This case report describes the clinical findings, treatment and outcome of a four-year-old goat with type I diabetes mellitus. Weight loss, polydipsia and polyuria were the main clinical signs. Urinalysis revealed glucosuria, ketonuria and aciduria. The most important haematological and biochemical findings were anaemia attributable to parasitism, hyperglycaemia and hypoinsulinaemia. The goat was treated with insulin administered subcutaneously twice daily for almost four years. The goat developed bronchopneumonia at eight years of age and was euthanased. Postmortem examination showed degeneration of insulin-producing beta-cells of the pancreas.
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PMID:[Diabetes mellitus type 1 in a goat]. 1903 45

A 54-year-old man was admitted to hospital after being found unconscious in his home. He had a history of alcoholism, multiple drug addictions, and type I diabetes mellitus. At admission, he had hyperglycaemia (550 mg/dL) with glucosuria and ketone bodies in the urine, along with septic shock refractory to bilateral alveolar infiltrates and severe respiratory failure. The patient died 24 hours post admission due to multiple organ failure, with diabetic ketoacidosis decompensated by possible respiratory infection in a patient with polytoxicomania. The autopsy confirmed the presence of acute bilateral bronchopneumonia, chronic pancreatitis, severe hepatic steatosis, and generalized congestive changes. At the oesophagus, acute oesophageal necrosis was evident.
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PMID:Acute oesophageal necrosis (black oesophagus). 2694 46