Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011849 (diabetes)
277,896 document(s) hit in 31,850,051 MEDLINE articles (0.18 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin 67475
Sep 17073
hemoglobin 6421
Mol 6177
glucagon 5794
albumin 4327
HDL 3271
cytokine 2957
collagen 2651
ATP 2550
leptin 2419
renin 2333
gut 2166
superoxide dismutase 1804
adiponectin 1803
insulin receptor 1796
C-reactive protein 1793
HLA 1637
NIDDM 1586
TNF 1568
IDDM 1535
NOD 1528
tumor necrosis factor 1518
endoplasmic reticulum 1514
STZ 1449
catalase 1358
growth hormone 1317
IL-6 1271
somatostatin 1236
CD4 1230
angiotensin II 1198
She 1158
GLP-1 receptor 1132
peptidase 1081
serum albumin 1069
aldose reductase 1049
chronic renal failure 1043
vascular endothelial growth factor 1042
peroxisome proliferator-activated receptor 1012
proinsulin 998
GSH 994
fibrinogen 974
caspase-3 973
amylin 959
nitric oxide synthase 955
glutathione peroxidase 935
ACE 905
glucose transporter 901
glucokinase 874
IRS-1 825
peroxisome proliferator-activated receptor gamma 824
GLP-1 809
Pol 785
amylase 777
mTOR 777
AMP-activated protein kinase 774
MRI 768
glucosidase 768
glutamic acid decarboxylase 762
ATPase 756
CD8 746
interleukin-6 724
DPP 713
GLUT4 698
IL-10 684
calcium channel 640
autoantigen 638
inducible nitric oxide synthase 629
interferon 622
ADP 614
alkaline phosphatase 606
PI3K 606
fibronectin 606
TNF-alpha 596
AMPK 593
p38 588
AKT 582
angiotensin receptor 581
ROS 574
AMP 573
more...
Disease
diabetes 277896
hypertension 30437
obesity 27445
type 2 diabetes 25264
hyperglycemia 15274
cardiovascular disease 13560
cancer 12555
type 1 diabetes 11648
atherosclerosis 8882
renal disease 8348
stroke 7424
metabolic syndrome 7253
hypoglycemia 6566
glucose intolerance 5620
diabetic nephropathy 5402
myocardial infarction 5227
dyslipidemia 5158
coronary artery disease 4983
heart failure 4722
hyperlipidemia 4598
retinopathy 4146
diabetic retinopathy 3858
coronary heart disease 3787
neuropathy 3603
depression 3586
hyperinsulinemia 3325
Alzheimer's disease 3250
heart disease 2973
renal failure 2850
tumor 2837
hypercholesterolemia 2763
ischemia 2714
vascular disease 2541
proteinuria 2496
myocardial ischemia 2483
gestational diabetes mellitus 2371
microalbuminuria 2171
chronic disease 2139
osteoporosis 2019
diabetic neuropathy 1965
chronic renal failure 1964
fatty liver 1858
cirrhosis 1834
asthma 1825
autoimmune disease 1739
dementia 1694
congestive heart failure 1658
rheumatoid arthritis 1637
HIV 1574
peripheral neuropathy 1563
NOD 1528
prediabetes 1465
anemia 1460
infectious diseases 1403
arthritis 1380
sepsis 1370
diabetic ketoacidosis 1353
cognitive impairment 1333
liver disease 1326
plaque 1298
chronic obstructive pulmonary disease 1279
acute myocardial infarction 1269
blindness 1245
autonomic neuropathy 1239
metabolic disorder 1236
peripheral vascular disease 1235
sepsis 1210
malnutrition 1171
tuberculosis 1162
cardiomyopathy 1098
diabetic cardiomyopathy 1088
breast cancer 1082
hepatocellular carcinoma 1039
hypothyroidism 1033
GSH 995
cataract 938
pancreatitis 935
pneumonia 922
systemic lupus erythematosus 917
multiple sclerosis 903
more...
Symptom
overweight 3482
pain 3351
angina 1337
diarrhea 767
anesthesia 732
fatigue 669
weakness 657
abdominal pain 608
headache 541
starvation 533
seizures 487
vomiting 476
nausea 470
polyuria 464
chest pain 415
dyspnea 365
respiratory distress 348
polydipsia 346
cough 342
discomfort 316
discomfort 272
constipation 258
anorexia 240
back pain 232
ketonuria 231
exhaustion 219
ataxia 210
dizziness 204
insomnia 199
hepatomegaly 187
sleepiness 187
cachexia 179
erythema 174
hunger 172
numbness 167
collapse 158
analgesia 151
functional recovery 141
ophthalmoplegia 135
thinning 131
syncope 128
nausea and vomiting 120
hypothermia 119
stigma 112
tremor 109
paresthesia 109
myalgia 106
Ill 104
shortness of breath 100
flushing 99
arthralgia 97
lethargy 93
dysarthria 93
Neuropathic pain 93
vertigo 87
low back pain 84
memory loss 81
snoring 81
spasm 79
hemoptysis 67
epigastric pain 66
hemiplegia 64
bloating 63
chills 62
cerebellar ataxia 62
hypotonia 60
Wind 59
dry eye 59
tinnitus 58
flank pain 57
acute stress 54
paresis 54
oliguria 51
dysuria 49
splenomegaly 49
Depressive symptoms 49
chorea 45
HSA 45
hypercapnia 45
hypoproteinemia 44
more...
Drug
Cardiovasc 2249
lysine 918
Glucagon 831
Dermatol 805
vitamin E 601
ROS 574
Dial 567
ascorbate 520
IFN-gamma 454
IL-2 332
Monit 303
ADM 269
NADH 242
Nephron 241
Albumin 212
caffeine 212
niacin 210
ROC 208
Angiotensin II 185
Rosiglitazone 184
Liraglutide 179
Nephron 174
CSF 172
Leaf 153
DM1 152
MAP 152
Growth hormone 147
Troglitazone 146
Growth hormone 143
nitroglycerin 143
Fructose 142
Exenatide 136
Vitamin E 135
PTH 132
Spectrum 126
Gliclazide 126
Asthma 104
Gel 101
Aminoguanidine 101
ampicillin 100
Tacrolimus 94
Glutathione 91
CTX 87
Simvastatin 81
Bifidobacterium 79
citric acid 75
Ramipril 75
lactose 73
Captopril 69
Fluorescein 68
Indomethacin 68
FAD 67
EPA 66
EPI 66
Nitric Oxide 63
ENT 63
Valsartan 62
ALA 62
ABC 61
Portal 59
Aloe 58
Clopidogrel 57
Vitamin A 56
Perindopril 56
Insulin glargine 55
Ginseng 53
Insulin detemir 52
CPR 52
AHF 52
BH4 51
CTX 51
CTX 51
Ethanol 50
Orlistat 50
Glide 49
p75 49
NAG 49
EE2 48
Fluorescein 47
Serum albumin 47
more...
Enzyme
renin 2333
superoxide dismutase 2110
mitogen-activated protein kinase 1719
protein kinase 1509
catalase 1481
ACE 1466
AMP-activated protein kinase 1310
protein kinase C 1254
aldose reductase 1062
glutathione peroxidase 942
glucokinase 875
ERK 834
ATPase 828
alanine aminotransferase 809
caspase-3 740
AMPK 646
aspartate aminotransferase 631
alkaline phosphatase 608
NADPH oxidase 606
AMPK 593
NO synthase 502
NADPH oxidase 490
lipoprotein lipase 477
alpha-glucosidase 476
focal adhesion kinase 449
peroxidase 408
luciferase 405
lactate dehydrogenase 392
glucose-6-phosphatase 383
collagenase 380
lipase 379
thrombin 377
calcineurin 369
phosphodiesterase 358
phosphoenolpyruvate carboxykinase 350
phosphatidylinositol 3-kinase 338
hexokinase 331
GSK 324
creatine kinase 319
proteasome 285
trypsin 280
acetylcholinesterase 269
phosphoenolpyruvate carboxykinase 265
PARP 259
glutathione reductase 259
ACS 259
phosphoenolpyruvate carboxykinase 257
tissue plasminogen activator 240
phosphorylase 236
glucose oxidase 230
aldehyde dehydrogenase 228
reverse transcriptase 223
AST 221
pyruvate dehydrogenase 214
glucose-6-phosphate dehydrogenase 214
adenylate cyclase 214
xanthine oxidase 198
APC 197
phosphoinositide 3-kinase 195
gamma-glutamyl transpeptidase 194
dipeptidyl peptidase IV 193
CAD 190
CAD 190
CAD 190
NOS 184
acetyl-CoA carboxylase 169
pyruvate kinase 165
pyruvate dehydrogenase 162
pyruvate dehydrogenase 162
phospholipase A2 161
glutathione S-transferase 158
complex I 156
kallikrein 153
CPT 151
ceruloplasmin 151
MEK 140
cholinesterase 139
glutamate decarboxylase 139
phospholipase C 137
caspase-1 136
more...
Compound
glucose 56842
Clin 25480
Dec 18563
Insulin 7550
oxygen 6112
DNA 5256
calcium 4894
creatinine 4532
sodium 3877
Cardiol 3869
water 3682
nitric oxide 3107
ATP 2551
STZ 2480
alloxan 2382
arginine 1973
phosphate 1740
Diabetol 1646
acetate 1616
potassium 1608
TNF 1568
urea 1385
galactose 1376
iron 1352
Diabetol 1216
tyrosine 1184
Metformin 1149
Metformin 1139
vitamin D 1139
nitrogen 1129
aldosterone 1118
lysine 1094
Pac 1075
GSH 1054
GSH 1054
zinc 1041
hydrogen 1004
ethanol 968
salt 870
cAMP 869
Glucagon 831
nicotinamide 823
His 779
Cholesterol 766
serine 754
alanine 748
leucine 730
ADP 719
DPP 713
sulfate 673
homocysteine 647
AMP 636
glycerol 625
ADP 621
ADP 614
cysteine 610
Dial 594
NAD 591
threonine 536
copper 524
glutamate 514
methionine 495
noradrenaline 458
prostacyclin 457
Angiotensin II 443
NAD 433
ASA 401
CO2 399
iodine 397
Retinal 389
TSH 388
Pima 383
glutamine 371
ACTH 362
phosphorus 362
NADPH 361
NADPH 360
Hemoglobin 359
CoA 357
Optimal 354
more...