Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.12 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin 67475
Sep 17073
hemoglobin 6421
Mol 6177
glucagon 5794
albumin 4327
HDL 3271
cytokine 2957
collagen 2651
ATP 2550
leptin 2419
renin 2333
gut 2166
superoxide dismutase 1804
adiponectin 1803
insulin receptor 1796
C-reactive protein 1793
HLA 1637
NIDDM 1586
TNF 1568
IDDM 1535
NOD 1528
tumor necrosis factor 1518
endoplasmic reticulum 1514
STZ 1449
catalase 1358
growth hormone 1317
IL-6 1271
somatostatin 1236
CD4 1230
angiotensin II 1198
She 1158
GLP-1 receptor 1132
peptidase 1081
serum albumin 1069
aldose reductase 1049
chronic renal failure 1043
vascular endothelial growth factor 1042
peroxisome proliferator-activated receptor 1012
proinsulin 998
GSH 994
fibrinogen 974
caspase-3 973
amylin 959
nitric oxide synthase 955
glutathione peroxidase 935
ACE 905
glucose transporter 901
glucokinase 874
IRS-1 825
peroxisome proliferator-activated receptor gamma 824
GLP-1 809
Pol 785
mTOR 777
amylase 777
AMP-activated protein kinase 774
MRI 768
glucosidase 768
glutamic acid decarboxylase 762
ATPase 756
CD8 746
interleukin-6 724
DPP 713
GLUT4 698
IL-10 684
calcium channel 640
autoantigen 638
inducible nitric oxide synthase 629
interferon 622
ADP 614
alkaline phosphatase 606
PI3K 606
fibronectin 606
TNF-alpha 596
AMPK 593
p38 588
AKT 582
angiotensin receptor 581
ROS 574
AMP 573
NMR 555
Bcl-2 551
insulin-like growth factor 540
axonal 537
MHC 518
major histocompatibility complex 516
lipopolysaccharide 514
polypeptide 504
DR4 501
CRP 498
vascular endothelium 496
phosphatase 495
histone 495
MAPK 491
Men 488
IFN 488
IGF-I 484
thymus 482
Leptin 481
IFN-gamma 473
lipoprotein lipase 471
glycoprotein 463
DR3 459
Ang II 456
endothelial nitric oxide synthase 454
PPAR 454
adipokine 452
GAD65 452
Kir6.2 451
IL-4 449
plasminogen activator inhibitor-1 446
p53 443
apolipoprotein 442
ERK1 433
NAD 433
Adiponectin 431
parathyroid hormone 430
tyrosine kinase 429
INS-1 424
IGF-1 421
protein kinase B 416
VEGF 416
SOD 413
aspartate aminotransferase 412
lymphoid 411
ferritin 407
ghrelin 407
alanine aminotransferase 407
resistin 399
ACTH 396
GAD 393
apolipoprotein B 392
JNK 390
RAGE 390
IA-2 389
thrombin 385
angiotensin II receptor 381
glucose-6-phosphatase 381
endothelin-1 379
glycogen synthase 379
ANOVA 377
epididymal 377
nuclear receptor 377
chemokine 376
GFR 375
lactate dehydrogenase 371
eNOS 367
IL-1 367
alpha-glucosidase 367
reductase 361
prolactin 360
NADPH 360
San 357
phosphodiesterase 356
microsomal 353
ERK 349
Pseudomonas 347
SARS 345
phosphatidylinositol 3-kinase 337
Gen 335
more...
Disease
diabetes 277896
hypertension 30437
obesity 27445
type 2 diabetes 25264
hyperglycemia 15274
cardiovascular disease 13560
cancer 12555
type 1 diabetes 11648
atherosclerosis 8882
renal disease 8348
stroke 7424
metabolic syndrome 7253
hypoglycemia 6566
glucose intolerance 5620
diabetic nephropathy 5402
myocardial infarction 5227
dyslipidemia 5158
coronary artery disease 4983
heart failure 4722
hyperlipidemia 4598
retinopathy 4146
diabetic retinopathy 3858
coronary heart disease 3787
neuropathy 3603
depression 3586
hyperinsulinemia 3325
Alzheimer's disease 3250
heart disease 2973
renal failure 2850
tumor 2837
hypercholesterolemia 2763
ischemia 2714
vascular disease 2541
proteinuria 2496
myocardial ischemia 2483
gestational diabetes mellitus 2371
microalbuminuria 2171
chronic disease 2139
osteoporosis 2019
diabetic neuropathy 1965
chronic renal failure 1964
fatty liver 1858
cirrhosis 1834
asthma 1825
autoimmune disease 1739
dementia 1694
congestive heart failure 1658
rheumatoid arthritis 1637
HIV 1574
peripheral neuropathy 1563
NOD 1528
prediabetes 1465
anemia 1460
infectious diseases 1403
arthritis 1380
sepsis 1370
diabetic ketoacidosis 1353
cognitive impairment 1333
liver disease 1326
plaque 1298
chronic obstructive pulmonary disease 1279
acute myocardial infarction 1269
blindness 1245
autonomic neuropathy 1239
metabolic disorder 1236
peripheral vascular disease 1235
sepsis 1210
malnutrition 1171
tuberculosis 1162
cardiomyopathy 1098
diabetic cardiomyopathy 1088
breast cancer 1082
hepatocellular carcinoma 1039
hypothyroidism 1033
GSH 995
cataract 938
pancreatitis 935
pneumonia 922
systemic lupus erythematosus 917
multiple sclerosis 903
renal insufficiency 902
erectile dysfunction 883
glomerulosclerosis 883
Parkinson's disease 869
AIDS 856
ventricular hypertrophy 820
essential hypertension 799
polyneuropathy 793
insulinoma 793
preeclampsia 781
SEM 780
hepatitis C 780
abdominal obesity 780
chronic pancreatitis 773
alcoholism 771
cold 769
arteriosclerosis 728
pancreatic cancer 692
polycystic ovary syndrome 689
cystic fibrosis 681
schizophrenia 663
periodontitis 662
West 660
carcinoma 653
epilepsy 644
immunodeficiency 631
osteoarthritis 589
periodontal disease 585
hyperphagia 585
psoriasis 570
hepatitis 569
virus infection 564
obstructive sleep apnea 559
celiac disease 537
alcoholic fatty liver 536
glaucoma 533
ketosis 528
deafness 519
prostate cancer 517
osteomyelitis 513
infertility 511
renal impairment 510
Infection 507
proliferative diabetic retinopathy 507
Nonalcoholic fatty liver 504
influenza 490
Pancreas 488
gangrene 487
inflammatory bowel disease 482
urinary tract infection 477
sleep apnea 475
Pancreas 474
uremia 472
hypogonadism 469
hyperuricemia 469
mental illness 466
transient ischemic attack 462
carcinogenesis 460
gout 455
hyperthyroidism 454
SARS 449
glomerulonephritis 445
fungal infection 441
hepatitis B 430
Best 427
adenocarcinoma 426
acromegaly 424
colorectal cancer 422
diabetic foot ulcers 418
dehydration 417
mucormycosis 415
vitamin D deficiency 413
lung disease 413
gallstones 411
macular edema 410
atherosclerotic cardiovascular disease 407
alcohol abuse 406
Diabetic foot 406
lipodystrophy 401
Evans 400
more...
Symptom
overweight 3482
pain 3351
angina 1337
diarrhea 767
anesthesia 732
fatigue 669
weakness 657
abdominal pain 608
headache 541
starvation 533
seizures 487
vomiting 476
nausea 470
polyuria 464
chest pain 415
dyspnea 365
respiratory distress 348
polydipsia 346
cough 342
discomfort 316
discomfort 272
constipation 258
anorexia 240
back pain 232
ketonuria 231
exhaustion 219
ataxia 210
dizziness 204
insomnia 199
hepatomegaly 187
sleepiness 187
cachexia 179
erythema 174
hunger 172
numbness 167
collapse 158
analgesia 151
functional recovery 141
ophthalmoplegia 135
thinning 131
syncope 128
nausea and vomiting 120
hypothermia 119
stigma 112
paresthesia 109
tremor 109
myalgia 106
Ill 104
shortness of breath 100
flushing 99
arthralgia 97
dysarthria 93
Neuropathic pain 93
lethargy 93
vertigo 87
low back pain 84
memory loss 81
snoring 81
spasm 79
hemoptysis 67
epigastric pain 66
hemiplegia 64
bloating 63
cerebellar ataxia 62
chills 62
hypotonia 60
Wind 59
dry eye 59
tinnitus 58
flank pain 57
acute stress 54
paresis 54
oliguria 51
splenomegaly 49
Depressive symptoms 49
dysuria 49
hypercapnia 45
HSA 45
chorea 45
hypoproteinemia 44
asthenia 43
acidity 42
hepatosplenomegaly 42
sore throat 41
hyperoxia 40
tachypnea 40
abdominal discomfort 39
leg pain 39
dystonia 37
ENT 37
menopausal symptoms 37
shoulder pain 36
blurred vision 36
masculinization 34
agitation 34
tingling 34
exertional dyspnea 33
regurgitation 33
pallor 33
hypertonia 33
neck pain 32
decreased appetite 31
dry skin 30
emaciation 28
hoarseness 28
acute pain 27
myoclonus 27
Cushingoid 26
Cushingoid 26
muscle stiffness 26
limb pain 26
paraparesis 25
knee pain 25
cyanosis 25
heartburn 25
enuresis 24
night sweats 24
urinary frequency 24
pelvic pain 23
apathy 23
acute abdomen 23
photophobia 23
consciousness disturbance 23
muscle cramps 23
otalgia 22
anosmia 22
productive cough 22
colic 22
Gastrointestinal symptoms 22
thigh pain 22
tense 22
spasticity 21
forgetfulness 21
Multimorbidity 21
dysesthesia 20
rales 20
stomach pain 20
fever of unknown origin 19
Decreased activity 19
wheezing 19
incoordination 19
rhinorrhea 19
skin damage 19
neuralgia 19
skin irritation 18
chronic cough 18
bitter taste 18
chronic constipation 18
muscle rigidity 17
exertional angina 17
nocturnal polyuria 16
hot flashes 16
leg edema 16
halitosis 16
rigors 16
facial pain 15
stridor 15
excessive sweating 15
chronic back pain 15
Poor sleep 15
more...
Drug
Cardiovasc 2249
lysine 918
Glucagon 831
Dermatol 805
vitamin E 601
ROS 574
Dial 567
ascorbate 520
IFN-gamma 454
IL-2 332
Monit 303
ADM 269
NADH 242
Nephron 241
caffeine 212
Albumin 212
niacin 210
ROC 208
Angiotensin II 185
Rosiglitazone 184
Liraglutide 179
Nephron 174
CSF 172
Leaf 153
DM1 152
MAP 152
Growth hormone 147
Troglitazone 146
nitroglycerin 143
Growth hormone 143
Fructose 142
Exenatide 136
Vitamin E 135
PTH 132
Spectrum 126
Gliclazide 126
Asthma 104
Aminoguanidine 101
Gel 101
ampicillin 100
Tacrolimus 94
Glutathione 91
CTX 87
Simvastatin 81
Bifidobacterium 79
citric acid 75
Ramipril 75
lactose 73
Captopril 69
Indomethacin 68
Fluorescein 68
FAD 67
EPI 66
EPA 66
Nitric Oxide 63
ENT 63
ALA 62
Valsartan 62
ABC 61
Portal 59
Aloe 58
Clopidogrel 57
Vitamin A 56
Perindopril 56
Insulin glargine 55
Ginseng 53
CPR 52
AHF 52
Insulin detemir 52
CTX 51
CTX 51
BH4 51
Orlistat 50
Ethanol 50
NAG 49
p75 49
Glide 49
EE2 48
Fluorescein 47
Serum albumin 47
Rosuvastatin 46
Pravastatin 44
Heme 44
Cilostazol 43
Estrogens 43
Bayer 43
Award 43
metformin hydrochloride 42
Pramlintide 42
Alanine 42
Asn 40
Alliance 40
Kenyan 40
Vitamin B 39
Rimonabant 38
Ezetimibe 37
Spectrum 36
Humulin 36
ICI 36
ETA 35
Bezafibrate 34
Fraction 34
Insulin lispro 34
Rutin 34
Diurnal 34
CVA 33
Viagra 32
Lovastatin 31
ZnO 31
Histamine 31
Ouabain 30
Prednisone 30
Check 30
Aliskiren 30
G-CSF 29
pyridoxal phosphate 29
Lantus 29
TAC 29
Olmesartan 29
Glycerol 29
Neoral 29
Humalog 28
IL-1ra 28
MRC 27
CAM 27
Forskolin 27
uPA 27
Ponalrestat 26
Norplant 26
Clonidine 25
DNase I 25
Ginger 25
Vitamin K 25
Posture 25
Mutagen 25
Viagra 25
Insulin aspart 25
Dakar 24
Sodium nitroprusside 24
TAT 24
TAK 23
NBT 23
ACT 23
Retinoic acid 23
Biopolymers 22
Parkin 22
HCH 22
Parkin 22
Glycyrrhiza 22
HCG 22
Fluconazole 21
Imatinib 21
Atropine 21
THF 20
Honey 20
DDAVP 20
Galactose 20
Gemfibrozil 19
Camp 19
Pregabalin 19
more...
Enzyme
renin 2333
superoxide dismutase 2110
mitogen-activated protein kinase 1719
protein kinase 1509
catalase 1481
ACE 1466
AMP-activated protein kinase 1310
protein kinase C 1254
aldose reductase 1062
glutathione peroxidase 942
glucokinase 875
ERK 834
ATPase 828
alanine aminotransferase 809
caspase-3 740
AMPK 646
aspartate aminotransferase 631
alkaline phosphatase 608
NADPH oxidase 606
AMPK 593
NO synthase 502
NADPH oxidase 490
lipoprotein lipase 477
alpha-glucosidase 476
focal adhesion kinase 449
peroxidase 408
luciferase 405
lactate dehydrogenase 392
glucose-6-phosphatase 383
collagenase 380
lipase 379
thrombin 377
calcineurin 369
phosphodiesterase 358
phosphoenolpyruvate carboxykinase 350
phosphatidylinositol 3-kinase 338
hexokinase 331
GSK 324
creatine kinase 319
proteasome 285
trypsin 280
acetylcholinesterase 269
phosphoenolpyruvate carboxykinase 265
ACS 259
PARP 259
glutathione reductase 259
phosphoenolpyruvate carboxykinase 257
tissue plasminogen activator 240
phosphorylase 236
glucose oxidase 230
aldehyde dehydrogenase 228
reverse transcriptase 223
AST 221
pyruvate dehydrogenase 214
glucose-6-phosphate dehydrogenase 214
adenylate cyclase 214
xanthine oxidase 198
APC 197
phosphoinositide 3-kinase 195
gamma-glutamyl transpeptidase 194
dipeptidyl peptidase IV 193
CAD 190
CAD 190
CAD 190
NOS 184
acetyl-CoA carboxylase 169
pyruvate kinase 165
pyruvate dehydrogenase 162
pyruvate dehydrogenase 162
phospholipase A2 161
glutathione S-transferase 158
complex I 156
kallikrein 153
CPT 151
ceruloplasmin 151
MEK 140
cholinesterase 139
glutamate decarboxylase 139
phospholipase C 137
caspase-1 136
phosphofructokinase 136
PDK1 127
thyroid peroxidase 120
guanylate cyclase 113
sucrase 111
lysozyme 110
plasmin 110
heme oxygenase 108
CD10 107
succinate dehydrogenase 106
RNase 105
MAP 105
invertase 104
paraoxonase 103
RNase 101
tyrosine hydroxylase 100
thromboplastin 98
CPR 97
paraoxonase 96
citrate synthase 94
monoamine oxidase 91
angiotensin-converting enzyme 2 90
insulin-degrading enzyme 89
elastase 88
alpha-amylase 88
glyceraldehyde-3-phosphate dehydrogenase 88
hormone-sensitive lipase 88
ATP synthase 87
urokinase-type plasminogen activator 87
arginase 86
furin 86
LPL 85
lipoxygenase 81
CPT 80
IKK 78
beta-galactosidase 77
CPT 77
sorbitol dehydrogenase 77
caspase-9 77
glyceraldehyde-3-phosphate dehydrogenase 73
11beta-hydroxysteroid dehydrogenase 72
alcohol dehydrogenase 72
glutamate dehydrogenase 71
RNA polymerase 71
glutamate dehydrogenase 71
diamine oxidase 70
3-hydroxy-3-methylglutaryl coenzyme A reductase 70
glutamate dehydrogenase 70
O-GlcNAc transferase 69
glycerol-3-phosphate dehydrogenase 69
neuraminidase 69
transglutaminase 68
NQO1 68
CYP3A4 66
endonuclease 66
AOR 66
glycerol-3-phosphate dehydrogenase 66
cytochrome oxidase 64
adenosine deaminase 63
adenosine deaminase 63
glyceraldehyde-3-phosphate dehydrogenase 61
acid phosphatase 59
methylenetetrahydrofolate reductase 58
methylenetetrahydrofolate reductase 58
caspase-8 58
glyceraldehyde-3-phosphate dehydrogenase 55
soluble epoxide hydrolase 55
glyceraldehyde-3-phosphate dehydrogenase 55
PDE 54
cdc2 54
HSD 53
MIP 53
pyruvate carboxylase 53
CaMKII 52
pepsin 52
cholesterol acyltransferase 50
protein phosphatase 2A 49
hexosaminidase 48
diaphorase 47
aldehyde dehydrogenase 47
more...
Compound
glucose 56842
Clin 25480
Dec 18563
Insulin 7550
oxygen 6112
DNA 5256
calcium 4894
creatinine 4532
sodium 3877
Cardiol 3869
water 3682
nitric oxide 3107
ATP 2551
STZ 2480
alloxan 2382
arginine 1973
phosphate 1740
Diabetol 1646
acetate 1616
potassium 1608
TNF 1568
urea 1385
galactose 1376
iron 1352
Diabetol 1216
tyrosine 1184
Metformin 1149
vitamin D 1139
Metformin 1139
nitrogen 1129
aldosterone 1118
lysine 1094
Pac 1075
GSH 1054
GSH 1054
zinc 1041
hydrogen 1004
ethanol 968
salt 870
cAMP 869
Glucagon 831
nicotinamide 823
His 779
Cholesterol 766
serine 754
alanine 748
leucine 730
ADP 719
DPP 713
sulfate 673
homocysteine 647
AMP 636
glycerol 625
ADP 621
ADP 614
cysteine 610
Dial 594
NAD 591
threonine 536
copper 524
glutamate 514
methionine 495
noradrenaline 458
prostacyclin 457
Angiotensin II 443
NAD 433
ASA 401
CO2 399
iodine 397
Retinal 389
TSH 388
Pima 383
glutamine 371
ACTH 362
phosphorus 362
NADPH 361
NADPH 360
Hemoglobin 359
CoA 357
Optimal 354
Sodium 353
silver 351
tryptophan 341
Vitamin D 339
methanol 337
palmitic acid 335
MDA 325
tryptophan 318
nitrate 316
Phe 315
selenium 314
MTT 311
tryptophan 310
tryptophan 310
cGMP 310
H2O2 290
chromium 289
acetone 272
vanadium 271
PEG 269
SDS 269
GlcNAc 263
N-acetylcysteine 260
Ang II 257
Thyroid 256
ACS 256
proline 256
ACS 255
AGE 252
Pioglitazone 243
NADH 242
Asp 242
palmitic acid 227
valine 222
Resveratrol 219
ethyl acetate 218
Curcumin 217
Ile 215
caffeine 213
NH2 212
aldehyde 207
hexose 203
Mg2+ 199
glucose-6-phosphate 198
retinoic acid 194
Adrenal 191
Methylglyoxal 190
acetic acid 189
5-HT 188
GABA 186
DBP 186
Estrogen 185
FFA 184
EDTA 184
nicotinic acid 184
Glibenclamide 184
retinol 184
DBP 183
DPPH 183
pentosidine 183
GABA 181
EDTA 178
hexose 176
hexose 176
hexose 176
cadmium 169
superoxide radical 167
aldehyde 166
Collagen 166
PEG 166
ACh 165
FK506 165
8-OHdG 164
manganese 163
TOF 162
CAT 160
THP 160
Vitamin E 159
GTP 158
L-carnitine 157
more...