Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011849 (
diabetes
)
277,896
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Diabetes mellitus
(DM) is a chronic disease found worldwide. Notably, BKS.Cg- Dock7
m
+/+
Lepr
db
/JNarl mice are useful animal models for studying type 2 diabetes mellitus (T2DM). In this study, we investigated casein kinase 2 alpha 1 (CSNK2A1) gene and protein expression in the liver tissues of mice at different ages (4, 16, and 32 weeks) using real-time quantitative polymerase chain reactions, western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay. Our data paved the way for exploring BKS.Cg- Dock7
m
+/+ Lepr
db
/JNarl in the mouse model by demonstrating a significant increase in gene and protein expression in T2DM (+Lepr
db
/+Lepr
db
) mouse liver when compared to control (+Dock7
m
/+Dock7
m
) mouse liver. We also observed that
CSNK2A1 protein
level in the serum of T2DM patient group was higher than that of the control group, although the data was not statistically significant. Based on our findings, we can now understand the role of
CSNK2A1
gene upregulation when encountering T2DM pathologies.
...
PMID:Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity. 3192 34
