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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Relating to the Williams' report suggesting twofold higher incidence of diabetes mellitus in patients with the cancer of the colon, the study aiming at comparing an incidence of diabetes mellitus in patients with stomach, lung, and colon malignancies were carried out. Coexistence of the above listed neoplasms with diabetes mellitus type II was assessed in patients hospitalized at the Department of Gastroenterology and Metabolic Diseases, Institute of the Internal Diseases, Medical Academy in Warsaw within 1978-1986. Moreover, glycaemia and insulinemia curves were plotted following oral glucose load (75 g) in 16 patients with the cancer of the colon and 15 patients without malignancy. Only patients with body weight not exceeding 10% of the normal body weight, without history of diabetes mellitus and not treated with corticosteroids were classified for the study. Mean glycaemia and insulinemia values did not differ statistically in the investigated groups except statistically significantly higher serum insulin level in patients with cancer of the lung in the thirties minute of the test. Differences statistically significant were also not observed in retrospective analysis. However, an incidence of diabetes mellitus in patients with the cancer of the colon was 10.5% being higher than mean incidence of diabetes mellitus in this age group. Moreover, glucose load test has shown tolerance abnormalities in 4 patients with cancer of the colon, 1 patient with cancer of the lung, and 1 patient without malignancy. The obtained results indicate tendency to higher incidence of carbohydrate metabolism disorders in patients with cancer of the colon.
Pol Tyg Lek
PMID:[Glucose tolerance disorders in patients with cancer of the colon]. 208 19

In 50 subjects with arteriosclerotic ischaemia of the lower extremities and 41 subjects with diabetes mellitus ozone was applied intra-arterially. Before and after the treatment serum lipids concentration was examined. In the group with arteriosclerotic ischemia significant decrease in cholesterol level and both his fractions was seen. Whereas in the group with diabetes the cholesterol LDL was significantly reduced. In both groups total lipids level serum was decreased. It suggests that ++ozone therapy set back the arteriosclerosis progress, normalized some parameters of lipid metabolism and improved HDL to LDL cholesterol fractions relationship.
Pol Tyg Lek
PMID:[Various parameters of lipid metabolism after intra-arterial injections of ozone in patients with ischemia of the lower extremities and diabetes mellitus]. 210 39

In this successive report on the coexistence of peptic ulcer disease with diseases of other systems the coincidence is described of peptic ulcer with urinary system diseases and diabetes. In a population of 5813 patients with peptic ulcer studied using the "Ulcer" informatic programme urinary tract diseases were found in 6.21%, and diabetes in 1.41%. Differences are discussed in the prevalence of peptic ulcer and urinary tract disease or diabetes between males and females, and the age of the patients and frequency of various locations of ulcer in these cases.
Mater Med Pol
PMID:Natural history of peptic ulcer disease in Poland. Part X. Peptic ulcer disease and urinary tract diseases and diabetes. 213 30

The role of insulin in the control of triacyglycerol (TG) in different types of skeletal muscle has not been fully recognized so the aim of the present study was to fill this gap. The experiments were carried out on control rats, those fed with olive oil or fed with the oil and treated with insulin and on streptozotocin diabetic animals at rest and there after exercise till exhaustion. The level of TG was measured in the white and red layers of the vastus lateralis, the soleus and the diaphragm. It was found that acute feeding with olive oil had no effect on TG level in either muscle type examined. Insulin administered to rats fed with oil increased TG level in the red vastus. Streptozotocin diabetes caused an increase in TG level in muscles with high oxidative potential. Exercise lowered the level of TG only in the red vastus of the diabetic rats. It is concluded that insulin may increase muscle TG level. Accumulation of TG in muscles of rats with acute diabetes is likely to be a result of the high plasma free fatty acid concentration. Acute insulin deficiency did not affect the muscle TG response to exercise.
Acta Physiol Pol 1990
PMID:The role of insulin in the control of triacyglycerol (TG) in the rat skeletal muscles. 213 89

In 30 diabetics (15 with type I and 15 with type II) and in 15 healthy controls the effect was studied of two-hour immersion in water on the concentration of atrial natriuretic peptide, sodium and potassium in serum, diuresis and natriuresis, mean arterial pressure and percent change of circulating plasma volume. Diabetics with either type of diabetes differed from the controls by a significantly lower concentration of the atrial natriuretic peptide under basal conditions, and lower rise of the peptide during immersion in water. Type I diabetics differed from type II diabetics and controls in that their natriuresis was lower under basal conditions and during immersion. On the basis of these results the authors conclude that in diabetics the reaction of atrial natriuretic peptide secretion to central hypervolaemia is preserved but weaker, and the role of this hormone in the pathogenesis of increased diuresis and natriuresis induced by water immersion is smaller in these patients than in controls.
Pol Arch Med Wewn
PMID:[Studies of atrial natriuretic peptide, diuresis and natriuresis in patients with diabetes mellitus types 1 and 2 after water immersion]. 214 81

In 18 patients with type I diabetes the effect was studied of 10 days of Indobufen administration in daily doses of 400 mg on the activation and function of platelets. Spontaneous and ADP and adrenaline-induced aggregation, adhesiveness, platelet factors 3 and 4, and generation of malonyldialdehyde (MDA) in platelets were investigated. The results were compared with similar results in the same group prior to the treatment and in a control group of 19 healthy subjects. Highly significant inhibition was noted of spontaneous inhibition and that evoked by adrenaline and ADP, and a considerable reduction of MDA generation by platelets. These results indicate that the new platelet inhibitor--Indobufen, effectively inhibiting platelet activation and function may prevent development of thrombotic complications of diabetes.
Pol Arch Med Wewn 1990 Mar
PMID:[Activation and functions of blood platelets in patients with diabetes mellitus type 1 before and during the treatment with indobufen]. 221 38

Selection of indications and the general tactics of nifedipine monotherapy of hypertension in diabetic subjects is not clearly established, as yet. It refers specifically to different forms and phases of diabetes mellitus. This was the reason to carry out a respective study. In 4 groups of hypertension: 1) in diabetics without vascular complications, 2) in diabetic nephropathy, 3) in diabetics type II without nephropathy, and 4) in comparative group of subjects without diabetes mellitus, a 6-week controlled, open trial was performed. Before, during and after nifedipine (3 X 10-20 mg p.d.), the following parameters were monitored: 1) systolic, diastolic and mean blood pressures, 2) glycaemic indices of diabetes control, 3) serum cholesterol: total, HDL, LDL, triglycerides, 4) daily albuminuria and GFR, 5) adverse reactions to nifedipine. It could be concluded that nifedipine therapy was relatively most effective and safe in hypertensive diabetics type II without nephropathy. It was less effective in diabetics type I without nephropathy and failed in diabetics type I with nephropathy.
Pol Tyg Lek
PMID:[Effectiveness of nifedipine in the treatment of arterial hypertension in various types of diabetes mellitus]. 221 50

Health status of 53 babies delivered by diabetic mothers are discussed. Neonatal period was uncomplicated only in 12 cases. The remaining babies suffered from respiratory disorders, edema, neurological disturbances, prolonged jaundice, infections etc. Metabolic disorders in diabetic female are unfavourable for the development of pregnancy and neonate health. it may be improved by the proper diagnostico-therapeutical management prior to and during pregnancy and by intensive care of neonates after delivery. It requires, however, the establishment of health institution with highly qualified teams well equipped which will be able to carry out diagnosis and therapy of diabetes mellitus in females in the reproductive age, during pregnancy as well as proper care of the neonates.
Pol Tyg Lek
PMID:[Neonatal complications in infants born to mothers with diabetes mellitus]. 223 99

A model of management of pregnant diabetic patients is proposed. Such a model has been implemented at the Voivodeship Out-patient Clinic for Diabetics. Proposed model includes recent data on diabetes mellitus complications and the effect of coexisting diseases on the mother and fetus health. Management was adapted to the real and potential possibilities of health service in Poland. A decrease in the rate of mortality of fetuses under 7% was achieved. It is worth emphasizing despite higher value than those reported in the literature.
Pol Tyg Lek
PMID:[A proposed model of the treatment of diabetes mellitus in pregnancy]. 223 5

Ten obese patients with normal glucose tolerance, 11 obese with type II diabetes and 15 normal non-obese controls were studied. The submaximal exercise test was made before fasting in all the mentioned 3 groups of patients and in the obese patients after a 10 days fast. The exercise on normal diet did not cause any changes in serum insulin in all groups. The growth hormone secretion, however, rose in all the groups studied. Fasting did not modify the insulin secretion following the exercise in both groups of the obese. The growth hormone secretion, exercise stimulated, was elevated by fasting as well in the obese with normal and abnormal glucose tolerance. We believe that a marked energetic deficit due to exercise on fasting may supplement the deficit of the growth hormone which usually occurs in obesity. This might be therapeutically usefull in treating obesity in selected cases.
Pol Arch Med Wewn 1990 Jul
PMID:[Blood levels of insulin and growth hormone during exercise test in obese patients with normal glucose tolerance and with diabetes mellitus after food intake and fasting]. 225 Dec 13


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