Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The maternal Serum concentrations of beta 1 SP 1, IgM and alpha 2-macroglobulin were determined in relation to the gestation age, using the simple radial immunodiffusion method in 102 non-pathologic pregnancies and 35 pregnancies involving risk factors. To assess the clinical relevance of these determinations, we examined to what extent the changes in concentration of beta 1 SP 1 IgM and alpha 2-macroglobulin would permit a prognostically useful conclusion on the placenta function and foetal condition. All patients with lowered beta 1 SP 1-serum concentrations were examined for their antepartua CTG-evaluation, as well as the type of termination of parturition. The normal distribution for beta 1 SP 1 showed a continuous rise in serum concentration up to the 37th pregnancy week. During the last 3 weeks, beta 1 SP 1 remained almost constant. For the cases with EPH-gestosis and placenta insufficiency, a beta 1 SP 1-concentration below the normal distribution level was found in the large majority of all cases. In diabetes mellitus during gravidity, twin gravidity and MHN, the determination of beta 1 SP 1 is not of any decisive prognostic significance. The maternal serum levels of IgM showed no significant differences when comparing normal pregnancy and risk pregnancy. The serum concentration of alpha 2-macroglobulin increased in both groups of patients with increasing gestation age. Of the three examined protein bodies, we consider beta 1 SP 1 to be a good, additional parameter for the assessment of the trophoblast function.
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PMID:[Comparative examinations of high-molecular maternal serum protein bodies during pregnancy--a contribution to biochemical pregnancy control (author's transl)]. 9 88

In electron microscopic observations on the villous cytotrophoblast in pathologic human placentas we find, besides a general increase of the amount of Langhans cells, significant ultrastructural differences according to the different diseases in pregnancy. Diabetes mellitus: the most striking observations are small, extremely electron dense mitochondria and a lot of intracellular filaments in a hydropic cytoplasm. Rh-incompatibility: according to the stage of placental damage the Langhans cells show a different structure. In light cases we find hydrolic cells with normal mitochondria as well as swollen ones. The plasmalemm shows a lot of foldings and dentations with the syncytium. In serious cases of rh-incompatibility the Langhans cells cover the trophoblastic basal membrane completely. Their electron density is even higher than that of the syncytium. Characteristic lysosomes appear. In the most serious cases the syncytium is completely destroyed and maximal hydropic Langhans cells cover the villi. EPH-gestosis: the Langhans cells show different phases of differentiation, but no other characteristic criteria. The importance of the Langhans cells for the regeneration of the syncytotrophoblast is discussed. Mitochondria and rough endoplasmic reticulum are obviously not formed in the syncytium but they must be regenerated by taking up Langhans cells by syncytial fusion.
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PMID:[The ultrastructure of Langhans cells in pathologic human placentas (author's transl)]. 40 85

In this paper are defined new data about distribution, controlling factors, metabolism and aspects of physiological function of pregnancy-specific beta 1-glycoprotein during the second half of pregnancy. In high-risk pregnancies with diabetes, Rh-incompatibility and intrauterine death SP-1 concentrations in amniotic fluid were significantly increased. By evaluation of maternal serum concentrations of SP-1 in cases of high-risk pregnancies with EPH-gestosis and fetal retardation relevant results could be demonstrated.
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PMID:[Pregnancy-specific beta-1-glycoprotein (SP-1) during the second half of pregnancy]. 42 88

It is a well-known fact that pregnancy and parturition, as well as the post-partum period and puerperium, present special problems in multiparae. Hence, we compared 203 of our multiparae with the total group of 3251 parturients in respect of these parameters in a retrospective study. The results were as follows: Pregnancy of multiparae is characterized by an increased incidence of monosymptomatic or polysymptomatic EPH gestosis and by diabetes mellitus. In multiparae it was considerably less often necessary to induce labour than with the other parturients. There was in increased incidence of premature rupture, meconium-stained fluid, funicular complications, vagino-operative birth and delivery in sectio. Reduced desire to nurse the baby was significant sign in multiparae. There was also a significant increase in stillbirths and in the delivery of children with a birth weight of more than 4000 g. There was no increased incidence of monstrosities.
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PMID:[Pregnancy and parturition in multiparae (retrospective study in 203 patients) (author's transl)]. 43 74

The influence of pathological situations to fetal lung maturation during the last 9 weeks of pregnancy was studied. Lung maturity was determined by four different methods, analyzing the concentration of surfactant in amniotic fluid L/S ratio was measured planimetrically and densitometrically, foam test and surface tension of the liquor amnii were used on this purpose. 89 normal pregnancies for obtaining normal values served as a basis for comparison with pathological events. A general retardation of fetal lung maturity showed 26 patients with rhesus isoimmunization so as 26 patients with diabetes classes A, B and C (White). In three pregnancies complicated by diabetes class D a remarkable acceleration of fetal lung maturity was obvious. 30 patients with placental insufficiency sui generis presented a very inhomogenous development of the fetal lung, whereas in 35 patients with EPH-gestosis a minute acceleration between 33th and 37th week of gestation was found. A good correlation between all of the used methods for measuring the concentration of surfactant was noted. Best reliability in correct prediction of lung maturity showed the method of measuring the surface-tension of the amniotic fluid.
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PMID:[Fetal lung maturity in differen abnormal pregnancies (author's transl)]. 58 Jul 2

73 diabetic pregnant were controled and treated in our clinic 1976, there was a perinatale mortality of 2,7%. The great part of EPH--gestosis and infections of the urinary system and more operative deliveries show of a higher risk already in the stage of latent diabetes. By screening methodes for diabetics during pregnancy and by intensive control in the first trimester it will be possible to obtain better results in the future.
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PMID:[Experiences with centralized care for pregnant diabetic women--results of the 1976 treatment period]. 61 Feb 34

During a time interval of 2 years in 7% of the gravidae at the First Department of Obstetrics and Gynecology, University of Vienna, a surgical closure of the cervix was performed. The anamnestic and clinical data of these 221 gravidae were compared with a compatible collective of another 221 gravidae without a surgical closure (control-group). In the closuregroup 27,6% were primigravidae. The mean age of the gravidae was 28,8 years and statistically higher than in the control group (25,7 years). Also the mean age of the multigravidae at the time of their first gestation was statistically higher (23,9 years and 22 years respectively). The anamnestic amount of abortion and perinatal mortality was 63,5% and 24,3% respectively, significantly higher was also the anamnestic rate of curettages. In most of the cases surgical closure was indicated by palpation of the cervix, 3 degrees of insufficiency of the cervix were differentiated. There was a great importance of a postsurgical treatment with tocolytic drugs (83% and 10% respectively), but there was also a different mode of application. During the course of gestation a lower frequency of EPH-gestosis (64 gravidae and 90 gravidae respectively) but a higher incidence of diabetes (11 gravidae and 5 gravidae respectively) and a higher incidence of urinary infection (20 gravidae and 7 gravidae respectively) were observed. In patients with a cervical closure a higher rate of rupture of membranes and premature labor were present. Surgical technique and time of closure had no significant influence on the outcome of pregnancy. The rate of success was 86.4%.
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PMID:[Anamnesis and course of gestation associated with surgical closure of the cervix (author's transl)]. 64 67

Following a description of the three different functions of the placenta (respiratory, nutritive, endocrine) and their failures the most common function tests are presented. Special emphasis is put on the evaluation of a recently described pregnancy-specific protein (SP1) in the maternal serum. The amount of the substance produced by the placenta correlates well with the fetal weight and well-being in cases of EPH-gestosis and idiopathic placental insufficiency; correlation was not as well in mild EPH-gestosis, diabetes and RH-incompatibility. The validity of measuring SP1-production seems to be similar to that of HPL. The method of quantitative determination is simple and possible even in a smaller hospital.
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PMID:[Diagnosis of the placental function with special reference to the pregnancy-specific protein SP-1]. 84 69

Between 1. 6. 1972 and 31. 12. 1974 obese gravidae with a body weight of 90 kg or more were observed (7,6% of all patients in this period). This 315 patients were compared with a group of 315 patients with normal body weight chosen by random. The results of both groups were compared and evaluated by statistic (t-test, x2-test). A significant higher rate of Diabetes, latent Diabetes, EPH-Gestosis and cases of over-term deliveries were found in the group of obese patients.
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PMID:[The importance of the risk factor "obesity" during gravidy (author's transl)]. 93 9

Determination of the creatinine concentration of the amniotic fluid was undertaken between the 25th and 40th week of gestation in 114 patients. The normal serum creatinine level was simultaneously determined in 43 of these patients. The aim of this study was to examine whether this parameter of fetal renal function allows a conclusion to be drawn with respect to fetal maturity and the length of gestation. With increasing length of gestation a marked increase in the amniotic fluid and the maternal serum creatinine concentration was observed (p less than 0.01). The large scatter of the values made it impossible to relate any particular creatinine concentration to a certain week of gestation. However, if the concentration of creatinine in the amniotic fluid has reached a value of 2 mg% or more, a mature baby can be predicted in most cases. A tendency to raised levels of creatinine was seen in cases of EPH gestosis and latent diabetes mellitus. The determination of creatinine in the amniotic fluid can be recommended with certain reservations as an additional method to assess fetal maturity.
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PMID:[Creatinine during pregnancy (author's transl)]. 99 51


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