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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A randomized controlled study covering a two-year pre-treatment and a five-year post-treatment period was performed in 42 patients with diabetic retinopathy given photocoagulation treatment in one eye. Patients with progressive diabetic retinopathy of equal intensity in both eyes were selected from a single diabetes department. The course of diabetic retinopathy was assessed by ophthalmoscopy and composite fundus photographs as well as fluorescence angiography. In the first two-year post-treatment period non-proliferative retinopathy improved in the coagulated eyes and also, albeit to a lower degree, in the control eyes. In the next three years the treated eyes showed further improvement or stabilization, whereas the control eyes showed either stabilization or deterioration of the retinopathy. The most favourable results were obtained in proliferative diabetic retinopathy, which regressed in the majority of the eyes, the other eyes remaining stable or progressing only very slightly, in contrast with the control eyes, in the great majority of which proliferative diabetic retinopathy developed or progressed.
Doc Ophthalmol 1979 Dec 14
PMID:Photocoagulation treatment in diabetic retinopathy: a two-year pre- and five-year post-treatment study. 9 8

In various diseases of the kidney and the urinary bladder, in disturbances of potency and diseases of the outer genital the diabetes mellitus play an essential role. It was the aim the present investigations to establish with the help of manometric examinations of the urinary bladder in diabetics as well as in a comparative group which had no disturbed metabolism in what extent there exist objectively provable differences of the parameters chosen by us. From the results is to be stated that in diabetics, despite a slight increase of the capacity of the urinary bladder, a significant increase of the sphincter opening pressure and of the voluntary tonus of the sphincter is present. We explain these changes as an expression of a beginning disturbance of the innervation of the urinary bladder. In males of this age group from this result disturbances of miction which may lead to incorrect judgments, particularly in connection with a prostatic adenoma.
Z Urol Nephrol 1979 Dec
PMID:[Urodynamic studies on normal bladders and bladders in metabolic disorders using diabetes mellitus as an example]. 9 39

This study investigates the effects of insulin antibody binding on free insulin levels measured in patients with acute diabetic ketoacidosis receiving insulin by constant infusion. In spite of antibody binding ranging from 10 to 90 per cent of the total circulating insulin, the steady state concentrations of free insulin were similar to those observed in individuals on identical infusion rates but without insulin-binding antibodies. However, the levels of free insulin in two patients were substantially lower than expected for the rate of insulin infusion, even though levels of bound insulin were not greatly elevated. An infusion rate of at least 4 U. per hour produced satisfactory rate of fall of plasma glucose, whereas lower dose regimens (2 U. per hour)--producing steady state free insulin concentrations ranging from 28 to 49 mU. per liter in different subjects--were unreliable in controlling the metabolic abnormalities of diabetic ketoacidosis.
Diabetes 1978 Dec
PMID:Antibody binding of insulin in diabetic ketoacidosis. 10 56


Diabetes 1979 Dec
PMID:Chronic hyperinsulinemia in the fetal rhesus monkey: effects on fetal growth and composition. 11 97


Diabetes 1979 Dec
PMID:Plasma and urine carnitine in diabetic ketosis. 11 98

Glucose tolerance and insulin and glucagon secretion were examined sequentially during 6 months of calorie and carbohydrate restriction in an obese, recent-onset, ketosis-resistant diabetic adult. The subject was then followed for 9 additional months, during which some weight was regained. Fasting plasma glucose levels returned to normal after 6 week of calorie restriction and remained normal during periods of carbohydrate refeeding. Normalization of 2-h plasma glucose concentrations after a standard oral carbohydrate load required 5 months, and glucose disposal after an iv glucose load did not return to normal until the end of the study. Insulin secretion in response to oral glucose reached maximal levels during the first months of weight reduction and then decreased as glucose tolerance continued to improve. Acute phase insulin release in response to iv glucose gradually increased throughout the study. Glucagon stimulation by iv arginine and suppression by iv glucose also returned to normal levels slowly over several months. Abnormalities in glucose tolerance and glucoregulatory hormone secretion of ketosis-resistant diabetes are totally reversible with prolonged dietary therapy. Reduction in tissue resistance to the action of insulin also appeared to be of major importance in the recovery of normal glucose tolerance in this subject.
J Clin Endocrinol Metab 1979 Dec
PMID:Normalization of insulin and glucagon secretion in ketosis-resistant diabetes mellitus with prolonged diet therapy. 11 19

The results of a longterm study showed that only a relatively small percentage of patients with limiting disturbance of glucose tolerance progressed in the direction of diabetic manifestation. There seems therefore to be grounds for the diagnostic term diabetes to be used only for clinically overt diabetes mellitus and to allow the definitions "subclinical diabetes, chemical diabetes, latent diabetes and symptomatic diabetes" to fall into disuse. On the question of quantity for the glucose tolerance test a 75 g load was proposed as a compromise because of the occasional poor tolerance of the 100 g load. For reasons of international comparability it seems better to adhere to the 50 to 100 g load as before.
MMW Munch Med Wochenschr 1979 Dec 07
PMID:[Present day problems in the diagnosis of diabetes (author's transl)]. 11 65

In an assessment of the degree of adrenergic activity in the course of diabetes mellitus, plasma levels and urinary excretion of norepinephrine and epinephrine were determined in 20 normal subjects and 47 diabetics: 11 in good control (group I), 23 in poor control (group II), 13 with frank ketoacidosis (group III). The study was repeated in groups II and III once good glycometabolic control had been achieved. Slightly above normal catecholamine levels were noted in group I, while there was a marked increase in group II. Group III shaved an enormous increase by comparison with the other two groups. After medical treatment values in group III fell to within the group I range. The conclusion is drawn that a close relationship exists between adrenergic acitivity and the degree of control of diabetes. The sympathetic nervous system, therefore, interferes in the course of diabetes with blood sugar control via numerous, complex mechanisms.
Minerva Med 1979 Dec 08
PMID:[Adrenergic activity and glycometabolic compensation in patients with diabetes mellitus]. 11 10

A retrospective study of adult congestive cardiomyopathy was carried out; the admission criteria being heart failure with cardiomegaly after the exclusion of known causes of heart failure. Coronary artery disease was excluded by forming two sub groups, one with proven normal coronary arteries at angiography or autopsy and the other with only assumedly normal coronary arteries. The results concern the study of the incidence of this disease which has been regularly seen over the last 10 years in departments with a large number of referrals of cardiomyopathy. --Professional factors are analysed to see if there is a higher incidence amongst the working classes. --Other factors are analysed by comparison with three control groups: normal, coronary and valvular disease, and diabetes which may be a predisposing factor, but not the serum cholesterol which is decreased in these patients. There is a significant association with smoking and alcoholism and the main biological sign of the latter condition, macrocytosis. This is also found in both coronary sub groups. The isolation of this alcohol factor in the genesis of congestive cardiomyopathy implies the possibility of reversing or stabilising the myocardial damage after its withdrawal, so changing the severe diagnosis associated with this disease.
Arch Mal Coeur Vaiss 1979 Dec
PMID:[Multicenter epidemiological survey of primary myocardiopathies. Apropos of 380 cases]. 12 Jan 46

Everted intestinal rings from partially starved rats accumulate the nonmetabolized amino acid 1-amino-cyclopentane-5-carboxylic acid (ACPC) at an enhanced rate. Plasma glucagon concentrations were found to be markedly elevated in these partially starved rats as well as in rats with experimentally induced diabetes, a condition previously shown to be associated with augmented intestinal uptake of amino acid. Treatment of partially starved rats with repeated injections of glucagon-binding antiserum prevented increased ACPC uptake of intestinal rings. Chronically elevated plasma glucagon levels may participate in the mechanism of the functional changes in the intestine in partial starvation.
Gastroenterology 1975 Dec
PMID:Treatment with glucagon-binding antibodies alters the intestinal response to starvation in the rat. 12 36


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