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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A literature review of the effect of oral contraceptive (o.c.) use on various metabolic processes is presented. Several studies show an adverse effect of o.c. use on subclinical diabetes and on patients with manifest insulin-independent diabetes. Some researchers have found a beneficial effect of o.c. use on older diabetics. It has not been determined whether the estrogen or gestagen component of o.c.s is responsible for this decrease in glucose tolerance, nor has the mechanism for this effect been discovered. Changes in various plasma protein concentrations have been observed during o.c. use, which affect the blood coagulation and the blood pressure regulation systems. The estrogen component appears to be responsible for the increase in the serum triglyceride concentration during o.c. use; the mechanism is still unknown. Some studies indicate that o.c. use causes an increase in serum cholesterol levels, which could promote gall stone formation. An increase in Vitamin A concentration has been observed during o.c. use. Riboflavin, folic acid, vitamin B 12, and ascorbic acid levels have been shown to decrease during o.c. use. A decrease in pyridoxin levels during o.c. use indicates an increased metabolism of tryptophan to nicotinic acid robosyl-5-phosphate. This would cause a decrease in serotonin production, which could be a cause of the depression experienced by some o.c. users. An increase in the plasma copper and caeruloplasmin levels during o.c. use is apparently due to the estrogen component. An increase in transferrin and the serum iron levels have been observed during o.c. use. Contradictory findings are reported concerning the plasma concentration of zinc.
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PMID:[Metabolic studies under administration of oral contraceptives. A review]. 34 1

In alloxan diabetes, serum zinc, copper, iron and magnesium were significantly higher than in normal rats, while the level of serum calcium, sodium, and potassium was lower than normal. Treatment with daonil or insulin led to a normalization, as expected of the level of serum glucose and most of the other elements, except for iron and potassium. When lycanol was used for treatment, the level of all elements returned to the normal except for blood glucose, zinc and potassium.
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PMID:Serum mineral changes in alloxan diabetes before and after treatment with some hypoglycemic drugs. 40 72

The intravenous injection of zinc or manganese chloride immediately before and 15 minutes after alloxan or dithizone prevented the usual hyperglycemia observed 24 hours after induction of diabetes. Injection of zinc chloride in alloxan diabetes led to normalization of sodium while zinc, copper, iron and magnesium remained high and calcium and potassium remained low as in alloxan. In case of dithizone diabetes, the administration of zinc salt led to an increase in serum zinc, magnesium and potassium and to a decrease in serum calcium while the sodium level returned to normal. Manganese plus alloxan led to a normalization of serum zinc, copper, potassium and sodium. In the case of dithizone plus manganese only magnesium was raised while the other elements were unchanged when compared to animals injected with dithizone only. Chromium and cobalt lowered the blood glucose to a certain extent however it did not affect most of the elements. The same changes occurred in all elements as with alloxan or dithizone alone. Pretreatment with ATP led to a normalization of serum zinc, copper, magnesium, sodium and potassium, while in case of iron it remained high and calcium remained low as that found in alloxan diabetic rats.
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PMID:Serum mineral changes due to exogenous ATP and certain trace elements in experimental diabetes. 44 5

References and texts in the fields of diabetes and clinical chemistry commonly report that ascorbic acid when given orally or parenterally gives a false-positive reaction to the copper reduction glucose test (Clinitest). This impression is based on a study in which ascorbic acid (250 mg./dl.) was added to urine in vitro, with a resultant positive-test reading in the absence of glucose. Ascorbic acid is a reducing agent, and theoretically it could interfere with the copper reduction method of glucose detection. In the current study 10 nondiabetic men were ingesting 4 and 6 gm. ascorbic acid per day. A total of 360 glucose detection tests with the copper reduction method were undertaken. In no instance was there a positive reaction to the glucose test.
Diabetes Care
PMID:Noneffect of oral urinary copper ascorbic acid on reduction glucose test. 55 83

Methyldopa has been reported to cause a false-positive urine glucose test by the copper reduction method (Clinitest). We investigated the effect of methyldopa on urine glucose tests in 30 patients by comparing commonly used glucose oxidase methods to Clinitest. The results of our study indicate that methyldopa does not interfere with the copper reduction method for urine glucose determination.
Diabetes Care
PMID:Noneffect of methyldopa on urine glucose tests. 55 84

Ancient Peruvian hair has been excavated from a series of archaeological sites on the Peruvian coast. After careful cleaning, examination by scanning electron microscopy revealed most of the samples to be in a state of preservation comparable to modern hair. No evidence of pathological conditions was observed. Trace metal composition was determined by atomic absorption and flame emission spectrophotometry and nitrogen by Kjeldahl analysis, producing the following results: (1) nitrogen is lost with time, while all other tested minerals except zinc and copper showed irregular increases; (2) relatively high chromium levels may indicate that diabetes was not present in the samples; and (3) no consistent trend in the ratio of calcium to strontium was found through time and across corresponding dietary shifts.
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PMID:Mineral analysis of ancient Peruvian hair. 63 29

We studied serum zinc, copper, ceruloplasmin, insulin, basal glycemia and cholesterol in 49 diabetics on oral anti-diabetic agent and in 10 normal people. We found there is an elevation of serum zinc, copper and ceruloplasmin in the diabetic group that is statistically significant (p less than 0.001). There is a significant correlation between zinc and insulin (p less than 0.001), and between the quotient zinc/copper and cholesterol (p less than 0.001). The increase of plasma zinc can reflect a deficient storage or a chronic hypersecretion of insulin in hyperglucemic patients. We think that the quotient zinc/copper/might play a role in the pathogenesis of the arteriosclerosis in diabetes.
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PMID:Serum, zinc, copper and insulin in diabetes mellitus. 66 89

In maturity onset diabetes the blood levels of total blood keto acids in terms of pyruvic, serum citric, calcium are significantly higher than in normal adults, while there is a decrease in reduced-blood glutathione, serum zinc, potassium and sodium levels. There were no significant differences between diabetes and normal adults in the serum levels of copper, ceruloplasmin oxidase activity, iron and magnesium.
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PMID:Blood-reduced glutathione, pyruvic acid, citric acid, ceruloplasmin oxidase activity and certain mineral changes in diabetes mellitus before and after treatment. 68 21

In cases of juvenile diabetes, there were lower than normal levels of reduced glutathione, ceruloplasmin oxidase activity, zinc, copper and sodium, while the other elements show no significant changes. The lower level of serum zinc, copper and sodium may be due to the osmotic diuresis and consequent polyurea of diabetes.
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PMID:Blood-reduced glutathione, serum ceruloplasmin and mineral changes in juvenile diabetes. 68 22

The safety and effectiveness of various contraceptive methods for use by diabetic women was assessed by examining the results of recent studies. IUDs and condoms and diaphragms in combination with spermicides were recommended as the most appropriate contraceptive methods for these women. Sterilization was advised for diabetic women with completed families. The rhythm method was not recommended due to the frequency of menstrual cycle irregularity among diabetic women. The conclusion was reached that oral contraceptives should not be prescribed for women with diabetes mellitus. Recent studies have found an association between oral contraceptive use and the acceleration of atherogenesis. Since diabetic women are known to be at greater risk of atherogenesis, the use of oral contraceptives by these women might further enhance the risk of atherogenesis. Metabolic studies have revealed that all women who use oral contraceptives experience increases in blood pressure and in blood lipid and glucose levels; these findings may have special relevancy for diabetic women. Based on these studies the recommendation was made that oral contraceptives not be used by women with subclinical diabetes. The sudden and severe rise in blood glucose levels associated with oral contraceptive use may accelerate the disease and lead to insulin dependency. Empirical studies have failed to support the theoretical contention that diabetic women who use IUDs are at greater risk of pelvic infection than non-diabetic women who use IUDs. Copper IUDs, however, may not be as effective for diabetic women as for women without diabetes. Plastic IUDs were recommended for diabetic women.
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PMID:Family planning and the diabetic mother. 75 99


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