Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011849 (
diabetes
)
277,896
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The role of interferon-gamma in autoimmune
diabetes
was assessed by breeding a null mutation of the
interferon-gamma receptor alpha chain
into the nonobese diabetic mouse strain, as well as into a simplified T cell receptor transgenic model of
diabetes
. In contrast to a previous report on abrogation of the interferon-gamma gene, mutation of the gene encoding its receptor led to drastic effects on disease in both mouse lines. Nonobese diabetic mice showed a marked inhibition of insulitis-both the kinetics and penetrance-and no signs of
diabetes
; the transgenic model exhibited near-normal insulitis, but this never evolved into
diabetes
, either spontaneously or after experimental provocation. This failure could not be explained by perturbations in the ratio of T helper cell phenotypes; rather, it reflected a defect in antigen-presenting cells or in the islet beta cell targets.
...
PMID:Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes. 939 Nov 15
