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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Reproductive dysfunction following insulin deficiency in Diabetes Mellitus has been well reported among diabetic patients. However, the mechanism through which Diabetes alters reproductive function remains oblivion. While most studies have focused on diabetes mellitus in male subjects, there have been cases on altered reproductive functions in females. These present study aims to investigate the effect of long term hyperglycemia on diabetic rats' ovary. Female Wistar rats were assigned into control and diabetic group, each consisting of five animals. The later was induced with STZ (50mg/Kg intraperitoneal injection) and the animals were sacrificed after 14 weeks. The blood glucose, body and organ weight, serum hormone level along with oxidative stress parameters of the ovary and uterus were determined. Histology of the ovary and expression levels of CD79 in the ovary was also assessed. The weight of the diabetic rats after the experiment was significantly lower (p<0.05) than the control. The level of Follicle Stimulating Hormone, Luteinizing hormone and estrogen was significantly lower in the diabetic group. The antioxidant enzymes catalase, superoxide dismutase (SOD) and glutathione-s-transferase (GST) were significantly lower in the diabetic ovary and uterus while the Malondialdehyde (MDA) concentration significantly increased compared to the control group. Histological observation of the ovary showed signs of chronic inflammation and immunohistochemistry for CD79 showed positive expression in the diabetic ovary. Our research findings suggest that Diabetes mellitus alters ovarian health by altering hormonal balance and stimulating oxidative damage.
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PMID:Long-Term Hyperglycemia Impairs Hormonal Balance and Induces Oxidative Damage in Ovaries of Streptozotocin-Induced Diabetic Wistar Rat. 3308 23

An ideal food-chemical combination that will promote insulin resistance and its consequent development of pancreatic beta-cell dysfunction may open a new vista for Type 2 diabetes (T2D) research. Thus, we investigated the modulatory effects of a high-fructose diet (FRC) combined with glyphosate (GP). Male albino Wistar rats were randomly divided into five groups of eight/group and received distilled water, FRC, GP, and their combinations orally for eight consecutive weeks. We assessed the changes in fasting blood glucose levels (FBGLs), biochemical indices, oxidative stress parameters, and organ histopathology. From the results obtained, FBGLs and serum insulin levels were increased in the FRC-GP (2.3-3.1 and 1.9-2.2 folds) treated rats compared with the control baseline group. Also, the FRC-GP high dose increased FBGLs (1.9 folds), insulin (1.4 folds), triglycerides (1.5 folds), and uric acid (2 folds) levels compared with the FRC group. Malondialdehyde levels increased in the pancreas (54% and 78%) and liver (31.3% and 56.6%) of the FRC-GP treated rats. The FRC-GP treatments reduced serum high-density lipoprotein (57%), total protein (47%), and antioxidant parameters (non-enzymatic and enzymatic, 1.6-1.9 folds) respectively in the treated animals. The weight of the pancreas relative to the body increased (2-3 folds) while we observed mild inflammation and vascular congestion in vital organs in the treated rats. Overall, these results demonstrate the potential of FRC-GP-diet to induce conditions of rats T2D. Also, this novel finding suggests a cost-effective GP as an alternative in this model type and provides further insight into understanding FRC-GP interactions.
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PMID:The use of combined high-fructose diet and glyphosate to model rats type 2 diabetes symptomatology. 3313 73


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