Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The position of the oxygen dissociation curve (ODC) is modulated by 2,3-diphosphoglycerate (2,3-DPG). Decreases in 2,3-DPG concentration within the red cell shift the curve to the left, whereas increases in concentration cause a shift to the right of the ODC. Some earlier studies on diabetic patients have reported that insulin treatment may reduce the red cell concentrations of 2,3-DPG, causing a shift of the ODC to the left, but the reports are contradictory. Three groups were compared in the present study: 1) nondiabetic control individuals (N = 19); 2) insulin-dependent diabetes mellitus (IDDM) patients (on insulin treatment) (N = 19); 3) non-insulin-dependent diabetes mellitus (NIDDM) patients using oral hypoglycemic agents and no insulin treatment (N = 22). The overall position of the ODC was the same for the three groups despite an increase of the glycosylated hemoglobin fraction that was expected to shift the ODC to the left in both groups of diabetic patients (HbA1c: control, 4.6%; IDDM, 10.5%; NIDDM, 9.0%). In IDDM patients, the effect of the glycosylated hemoglobin fraction on the position of the ODC appeared to be counterbalanced by small though statistically significant increases in 2,3-DPG concentration from 2.05 (control) to 2.45 mol/ml blood (IDDM). Though not statistically significant, an increase of 2,3-DPG also occurred in NIDDM patients, while red cell ATP levels were the same for all groups. The positions of the ODC were the same for control subjects, IDDM and NIDDM patients. Thus, the PO2 at 50% hemoglobin-oxygen saturation was 26.8, 28.2 and 28.5 mmHg for control, IDDM and NIDDM, respectively. In conclusion, our data question the idea of adverse side effects of insulin treatment on oxygen transport. In other words, the shift to the left reported by others to be caused by insulin treatment was not detected.
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PMID:The effects of 2,3-diphosphoglycerate, adenosine triphosphate, and glycosylated hemoglobin on the hemoglobin-oxygen affinity of diabetic patients. 1279 2

The article presents results of the study of electrophoretic agility of erythrocytes, their pro-oxidant characteristics and intra-cellular concentration of adenosine triphosphate (ATP) and 2,3-diphosphoglycerate (2,3-DPG) in patients with diabetes mellitus type I and II under implementation of therapy. The sampling included 46 patients with diabetes mellitus type I and II. The control group consisted of 22 healthy volunteers. 20 patients with diabetes mellitus type i received insulin protaphan and insulin actrapid, 26 patients with diabetes mellitus type II received preparations of sulfanylurea, biguanides, incretins. The analysis of blood was applied before and after course of treatment. The electrophoretic agility of erythrocytes was analyzed, including concentration of malonic dialdehyde in them, content of 2,3-DPG and ATP. In case of diabetes mellitus type I and II, the study established increasing of content of malonic dialdehyde, decreasing of electrophoretic agility of erythrocytes, concentration of ATP and 2,3-DPG in erythrocytes concerning physiological standard, mostly expressed in patients with diabetes mellitus type I. The therapy decreased concentration of malonic dialdehyde and increased electrophoretic agility of erythrocytes, content of ATP and 2,3-DPG as compared with indices before treatment. In patients with diabetes mellitus type II during treatment reduction of electrophoretic agility of erythrocytes and 2,3-DPG up to physiological standard was observed. The positive effect of the given clinical strategies during treatment of diabetes mellitus type I and II is conditioned by decreasing of stress reaction and activation of adaptation processes that is manifested at the level of micro-circulation by amelioration of oxygen-transport function of blood at the expense of increasing of electrophoretic agility of erythrocytes, level of 2,3-DPG and decreasing of destructive processes of membranes of erythrocytes.
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PMID:[The evaluation of adaptive possibilities of organism under therapy of diabetes mellitus type I and II.] 3084 Mar 72


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