Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011849 (
diabetes
)
277,896
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Diabetic retinopathy (DR) is a common microvascular complication of
diabetes
. Circulating endothelial progenitor cells (EPCs) are derived from bone marrow and are characterized by pathological retinal neovascularization.
Rho GTPase Activating Protein 22
(
ARHGAP22
) is a DR susceptibility gene that interacts with its downstream regulatory protein ras-related C3 botulinum toxin substrate 1 (Rac1), to assist in endothelial cell angiogenesis and increasing capillary permeability. The aim of this study was to elucidate the relationship between
ARHGAP22
expression and EPC levels in type 2 diabetes (T2D) patients with DR. Fifty T2D patients with DR were recruited. Circulating EPCs were characterized as CD31
+
/vascular endothelial growth factor-2
+
/CD45
dim
/CD133
+
and were quantified using triple staining flow cytometry. Real-time polymerase chain reaction tests were used to quantify
ARHGAP22
expression. We found that T2D patients with proliferative DR had significantly lower EPC levels than those with non-proliferative DR (
P
= 0.028). T2D patients with EPC levels above the median value (> 4 cells/10
5
events) had higher levels of
ARHGAP22
expression (
P
= 0.002). EPC levels were positively correlated with
ARHGAP22
expression (
r
= 0.364,
P
= 0.009). Among T2D patients with DR, a higher expression of
ARHGAP22
was associated with higher levels of EPCs.
ARHGAP22
may be involved in the mobilization or active circulation of EPCs, thus contributing to neovascularization during DR development.
...
PMID:High levels of circulating endothelial progenitor cells in patients with diabetic retinopathy are positively associated with ARHGAP22 expression. 2970 51
Diabetic retinopathy (DR) is considered a main cause for vision loss in
diabetes
. To our knowledge, there were no studies on the association of genetic variants with DR in Chinese Hui nationality. In our research, 34 single nucleotide polymorphisms (SNPs) that were reported to be associated with DR in other ethnics were genotyped in 123 subjects with DR and 12 subjects without DR among Chinese Hui population using MassARRAY system. Association analysis performed by PLINK showed three SNP loci rs2300782, rs2292239, and rs10491034 were correlated with DR incidence. Furthermore, the genotype frequency analysis and association analysis of SNP with DR stage revealed the GT and TT genotypes of rs2292239, CC genotype of rs2300782, and GG genotype of rs10491034 were risk genotypes and associated with the severity of DR, which may be helpful for the study of DR susceptibility in Chinese Hui population. Our study indicates the rs2300782 of gene CAMK4, rs2292239 of gene ERBB3, and rs10491034 of gene
ARHGAP22
are associated with DR incidence and severity among Chinese Hui population.
...
PMID:Associations of rs2300782
CAMK4
, rs2292239
ERBB3
and rs10491034
ARHGAP22
with Diabetic Retinopathy Among Chinese Hui Population. 3197 61
