Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The activities of the four enzymes catalyzing intracellular post-translational modifications of the collagen polypeptide chains were assayed in the kidneys of rats with streptozotocin diabetes. When the changes in the four enzyme activities were expressed per milligram of protein in the 15,000 X g supernatant of the kidney homogenates, there were no changes in any of the enzyme activities at four weeks and only slight increases in the prolyl and lysyl hydroxylase activities at 12 weeks after the induction of diabetes. When the changes were expressed as total enzyme activities per two kidneys, again no changes were found in any enzyme activity at four weeks, but at 12 weeks significant increases were found in all four enzyme activities, namely prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase, and collagen glucosyltransferase. The data would be consistent with an increased collagen synthesis in diabetic kidneys, but they do not support the hypothesis that there might be specific changes in some of these enzyme activities or in the level of certain posttranslational modifications of the collagen polypeptide chains in this disease.
Diabetes 1976 Nov
PMID:Intracellular enzymes of collagen biosynthesis in rat kidney in streptozotocin diabetes. 18 46

The collagen glucosyltransferase of renal cortex is increased in experimental diabetes and this increased may be partially reversed or prevented by insulin treatment. The absence of any consistent increase in the plasma collagen glucosyltransferase level in diabetes argues against the enzyme's having a significant role in the pathological thickening of capillary basement membranes. The biological significance of the increased renal glucosyltransferase activity in chemically-induced diabetes must therefore remain in doubt but it is possible that the high glucose concentration in the blood simply stimulates the synthesis of new enzyme protein in the kidney.
 ...
PMID:Influence of streptozitocin-induced diabetes on glycosyltransferase activities in plasma and renal cortex. 645 75