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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Atherogenic dyslipidemia, characterized by an increased level of lipoprotein (a) and a decreased level of adiponectin, is a major risk factor for cardiovascular diseases in diabetic patients. To reduce cardiovascular risk in diabetic patients, use of agents with antidiabetic and anti-atherogenic potential is required. Using an animal model of diabetes, we investigated the antiatherogenic potential of extracts of three medicinal plants: jujube, barberry, and saffron. For this, serum level of fasting blood glucose, lipid profile, malondialdehyde, total antioxidant capacity, adiponectin and lipoprotein (a) in diabetic control and extract treated groups were measured. Statistical analysis of measurements showed that serum levels of fasting blood glucose, triglyceride, and VLDL decreased significantly (P < 0.05) in all treated groups. Treatment with all extracts reduced lipid peroxidation and increased antioxidant capacity of the experimental diabetic groups. Serum adiponectin levels increased in all treated groups, whereas lipoprotein (a) levels decreased, most markedly when treated with jujube extract. Jujube, saffron, and barberry extracts are beneficial in ameliorating oxidative stress and atherogenic risk of diabetic rats. This highlights the benefits of further investigating the cardio-protective potential of medicinal plant extracts and evaluating their usefulness as cardio protective agents in clinical practice.
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PMID:Anti-atherogenic potential of jujube, saffron and barberry: anti-diabetic and antioxidant actions. 2660 Jul 52

One of the most common disorders of the endocrine system is diabetes mellitus. This disease is associated with dyslipidemia. Adiponectin is a protein hormone that secreted by adipocytes and has an important role in regulating of glucose and fatty acid metabolic pathways. This study was designed to investigate the changes in serum level of adiponectin in diabetic rats treated with hydroalcoholic extracts of three medicinal plants; jujube (Ziziphus jujuba), barberry (Berberis vulgaris) and saffron (Crocus sativus) in comparison with quercetin. Streptozotocin -induced diabetic male rats were gavaged with specified doses of the extracts (25 and 100mg/kg) for two weeks. At the end of treatment period, fasting blood specimens were collected. The levels of adiponectin, fasting blood sugar (FBS), total Cholesterol, triglycerides, HDL-C and LDL-C were measured. Statistical analysis showed that serum levels of triglyceride and VLDL decreased significantly (P<0.05) in all treated groups. FBS level in all treated groups, decreased significantly and reach to normoglycemic level (P<0.05). Except Jujube, other plant extracts had no effect on cholesterol. Jujube in two doses (25 and 100mg/kg) could increased significantly HDL-C (P<0.05) with no effect on total cholesterol and LDL-C. Serum adiponectin level increased in all treated groups. These beneficial effects of C. sativus, B. vulgaris and Z. jujube extracts and quercetin in diabetic rats may be associated with increase in adiponectin level.
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PMID:Hypoglycemic effects of three Iranian edible plants; jujube, barberry and saffron: Correlation with serum adiponectin level. 2663 3

Fruits are colorful, flavorful, and nutritious components and play an important role for the vital health and maintenance of our body. Experimental evidences suggested that fruits contain various bioactive constituents including flavonoids, polyphenols, carotenoids, and micronutrients such as vitamins and minerals. Because of these, fruits are receiving greater attention to treat and/or control various health complications such as diabetes, obesity, cancer, cardiovascular disease, immune system decline, and certain neurological disorders. Experimental evidences from various in vitro and in vivo imply that fruit extracts and/or isolated bioactive compounds are associated with antioxidant, anti-inflammatory, antimicrobial, cardioprotective, and neuroprotective properties. Therefore, fruits have the potential to be converted into functional foods as well as pharmaceuticals to prevent or/and treat several chronic complications. In the present article, we review current knowledge about the bioactivities and health benefits of selected Indian fruits for the treatment/management of the chronic health complications in humans. PRACTICAL APPLICATIONS: This review provides practical information about how best to take advantage of the bioactive compounds and health implications of the South Indian fruits like Bael, Jujube, Cotton Candy Berry, and Manilla Tamarind as a potential source of functional and nutritive compounds. It aims at emphasizing the most recent findings on biological effects of major groups of fruits like Bael, Jujube, Cotton Candy Berry, and Manilla Tamarind and their major components, their medical interest, potential drug interaction, notably for human nutrition, health benefits, and therapeutic impacts.
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PMID:Traditional fruits of South India: Bioactive components and their potential health implications in chronic diseases. 3252 77