Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011849 (diabetes)
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HIV patients taking protease inhibitors are sometimes reporting a wasting-related syndrome called lipodystrophy, Lipodystrophy is a condition in which the body does not process fats properly. Symptoms include loss of fat from the face and upper body, muscle loss in the arms and legs, pot belly, and abnormal fatty deposits referred to as buffalo humps. Diabetes occasionally occurs, and blood triglycerides are elevated. The syndrome was initially seen in patients on Crixivan, although use of other protease inhibitors can also cause this side effect. The forum for Collaborative AIDS Research is developing a clinical trial to learn more about this symptom. Patients experiencing the symptoms of lipodystrophy should contact the forum for Collaborative AIDS Research.
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PMID:Metabolic problems and PIs. 1136 32

Patients taking protease inhibitors are beginning to report a number of strange side effects that may be associated with the drugs, although that has not been conclusively proven. Side effects include new or exacerbated cases of diabetes or hyperglycemia, hemolytic anemia, spontaneous bleeding in hemophiliac patients, and changes in body composition. The first unusual symptoms were fatty deposits in the abdomen (Crix belly) and back (Buffalo humps), with wasting symptoms in the upper body. No hard data indicates that these symptoms are directly connected to protease inhibitor use. About 70 percent of all patients on protease inhibitors take Crixivan (indinavir). An Internet discussion group for patients to compare experiences with the drug is available.
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PMID:Protease inhibitor side effects take people by surprise. 1136 85