Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Heparin sodium is an extremely useful medication with demonstrated benefit in a number of clinical settings. Physicians need to be aware of the potential complication of hyperkalemia, especially in patients with renal insufficiency or diabetes mellitus. Discontinuation of heparin therapy is necessary to reverse the suppression of aldosterone. If heparin is the cause, the hyperkalemia will resolve within 5 days.
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PMID:Heparin-induced hyperkalemia. 231 39

Heparin sodium is routinely used in the prophylaxis against deep venous thrombosis in medical and surgical patients. While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized. We present four cases in which the use of heparin was associated with hyperkalemia and discuss the pathophysiology. Our findings suggest that hyperkalemia can develop with the use of low-dose heparin, within seven days of initiating heparin therapy, and that patients with diabetes mellitus or chronic renal insufficiency are especially predisposed to this complication.
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PMID:Heparin-induced hyperkalemia. 400 33