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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The epidemic of AIDS is a terrible and unexpected scourge that strikes persons in the most productive years of their lives and seriously threatens to drain the resources of our health care system. It is also a real risk to health care personnel, who must remember and adhere to universal precautions against blood-borne disease to prevent accidental infection on the job. At the same time they must not in any way deny proper and compassionate care, which all patients deserve, whatever their HIV status. Dermatologists, in particular, must be alert to early signs (often cutaneous) of HIV infection, and must be careful to take precautions against infection because many dermatologic procedures expose them to risk. The hopeful news is that early diagnosis of HIV infection and effective therapy with Zidovudine and other agents may prevent development of symptomatic infection and prolong the lives of HIV-infected patients, perhaps indefinitely. In future, physicians must consider HIV disease a chronic problem to be treated with the same care and attention, in hopes of promoting long-term survival, as diabetes or heart disease.
J Am Acad Dermatol 1990 Jun
PMID:HIV disease, from discovery to management: the major role of the dermatologist. 236 21

Of 500 individuals screened at the Out-Patient Clinic, Mycology Section of the Department of Dermatology, Government General Hospital, Madras, 83 adult males (16.6%) and two adult females (0.4%) had hairy ears. Family study in five probands (three males and two females) suggests an autosomal-dominant sex-limited inheritance of this entity, probably linked to the genes for beard hairs, which is peculiar to males in South India and Sri Lanka. There has been an increased incidence of diabetes mellitus in the affected group. A control study made in a similar population of 1030 (680 male and 350 female) individuals attending the general medical and surgical out-patient clinics revealed hairy ears in 23.1% (237 male adults and one female adult).
Clin Exp Dermatol 1990 May
PMID:Genetics of hairy ears in south Indians. 236 72

A clinical, histopathologic, laboratory and therapeutic study in 44 subjects with "superficial vasculitis", consecutively observed during the last two years, has been carried out. The findings showed that 1. the anamnesis was sometimes not relevant; 2. the clinical pictures were not in a regular manner correlated with histologic reports (a polymorphonuclear infiltrate with leukocytoclasis or a lymphomononuclear + one); and 3. a non-correlation between clinical, histologic and etiologic data. Infectious agents were responsible, mostly pyogenic bacteria, Mycobacterium tuberculosis, and hepatitis B virus; Chlamydiae were rarely responsible, whereas the etiologic role of Toxoplasma was uncertain. In this respect, drugs were not relevant. All these agents seem to act on the immunological response of the patient with previous microvascular changes (diabetes, chronic venous insufficiency). The latter condition seems to play a predominant role: the recovery of the lesions and/or their relapse shows the same behaviour both in case of etiological and symptomatic therapy.
G Ital Dermatol Venereol 1990 Feb
PMID:[Clinico-pathogenetic observations on the subject of "superficial vasculitis"]. 236 4

In this study the data on 200 patients affected by various features of lichen planus (LP) are reported. All subjects were in-patients of the Department of Dermatology, Bari, from 1973 to 1988. In 87% of cases the disease appeared as lichen tuber planus, and in 9% there was involvement of mucous membranes. Equal involvement of sex incidence has been found, and the patients were middle-aged (mean, 47 years). The lesion were not subsided in about 10% of cases. Associated fortuitous skin conditions were mainly alopecia areata and vitiligo. In addition, LP has been observed in association with diabetes (8%) and hepatic diseases (10%). These last values could appear relevant, but in our region, Apulia, both diabetes and hepatitis, and especially B-hepatitis, are very frequent diseases. Our clinical follow-up did not allow to consider LP as a symptom of other subsequent organic diseases.
G Ital Dermatol Venereol 1990 Mar
PMID:[A retrospective study of 200 cases of lichen]. 237 21

The microvessels in the buttock skin of 15 patients with long-standing juvenile diabetes were studied both by electron microscopy and three-dimensional (3D) computer reconstruction of a prototypical diabetic postcapillary venule. Endothelial cell gaps were found in postcapillary venules and capillaries, but only in association with an increased deposition of basement membrane-like material in the vascular wall. In parallel with the increased amounts of deposited basement membrane-like material, the space between pericytes and endothelial cells was wider and the cytoplasmic processes that formed the contact points between them were longer and thinner than normal. Pericytes, devoid of any cytoplasmic contacts with the underlying endothelial cells, were observed as isolated cells within the outer third of the vascular wall in markedly thickened vessels. These observations offer an explanation for the known increased vascular permeability of diabetic vessels, and suggest a possible explanation for the development of diabetic retinopathy with aneurysm formation.
J Invest Dermatol 1990 Aug
PMID:Ultrastructural analysis of the endothelial-pericyte relationship in diabetic cutaneous vessels. 238 May 75

A cross-sectional study and a retrospective study were performed to determine the frequency of balanitis in a randomly selected group of dermatology patients. A total of 398 subjects were included in the cross-sectional study, 213 (53.5%) of whom had been circumcised. Balanitis was diagnosed in 2.3% of circumcised men and in 12.5% of uncircumcised men. In patients with diabetes mellitus, balanitis occurred with a prevalence of 34.8% in the uncircumcised population, compared with 0% in the circumcised population. Balanitis did occur with increased frequency in the diabetic population (16%), regardless of circumcision status, compared with the nondiabetic population (5.8%). Of 63 circumcisions performed at our institution between 1987 and 1989, 28.6% were for the treatment of balanitis; 44.4%, for phimosis (which was probably induced by chronic balanitis); 19% in preparation for placement of penile prostheses; and 8% for miscellaneous reasons. No complications of circumcision were reported. In this group of patients, balanitis was more frequent in diabetic than in nondiabetic uncircumcised men (50% vs 15.4%).
Arch Dermatol 1990 Aug
PMID:An argument for circumcision. Prevention of balanitis in the adult. 238 29

Certain arachidonic metabolites may play a pathogenic role in psoriasis. Platelets are rich sources of 12-hydroxy-eicosatetraenoic acid (12-HETE) and thromboxane A2, mediators of skin inflammation and platelet aggregation, respectively. We have studied untreated psoriatic patients without a history of diabetes mellitus and smoking. In psoriatics, platelet aggregation elicited by thrombin, ADP, and ristocetin was significantly enhanced as compared with healthy adult volunteers. Enhancement of platelet aggregation was detected in patients with both minimal and widespread disease. The formation of 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT), a cyclooxygenase product, and 12-HETE, a 12-lipoxygenase product, was increased in psoriatics with widespread disease but not in those with minimal disease. Formation of 12-HETE was stimulated to a higher degree (125%) than HHT (98%) in psoriasis (P less than 0.05). Addition of platelet-derived 12-HETE to cultured human epidermal keratinocytes resulted in a stimulation of the DNA synthesis (68% at 10(-7) M). These data suggest that platelet activation occurs in psoriasis, and that release of inflammatory and mitogenic compounds by activated platelets may play a role in the pathophysiology of psoriasis. Whether enhanced platelet aggregation in psoriasis is associated with occlusive vascular disease needs further investigation.
Arch Dermatol Res 1986
PMID:Increased aggregation and arachidonic acid transformation by psoriatic platelets: evidence that platelet-derived 12-hydroxy-eicosatetraenoic acid increases keratinocyte DNA synthesis in vitro. 243 57

Developmentally caused skin malformations constitute a spectrum of birth defects, some of which can be recognized prenatally by morphologic or biochemical means. The number of prenatally diagnosable skin diseases could be greatly expanded with an increased understanding of the molecular and cellular bases of skin development and the mechanisms that result in the generation of skin defects. The National Institute of Child Health and Human Development and the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, therefore, sponsored a workshop that recommended basic biologic studies combined with clinical investigations of normal and abnormal cutaneous development set forth in this article. Investigations resulting from these research recommendations are intended to contribute to the knowledge that should aid in the prevention of developmentally caused skin deformities.
J Invest Dermatol 1987 Apr
PMID:Morphogenesis and malformations of the skin NICHD/NIADDK research workshop. 243 18

The process of nonenzymatic glycosylation (NEG) may play a significant role in the development of chronic complications of diabetes. Early products of NEG can be measured by various biochemical methods. A method has been developed to localize these early products of glycosylation in vivo in fixed tissue sections of normal and diabetic skin using monoclonal antibodies specific for glucitollysine, which is formed when the early products of NEG are chemically reduced in vitro. Carnoy's-fixed, paraffin-embedded skin samples from six diabetic and 13 nondiabetic subjects were sectioned, mounted on glass slides, and reduced for one h in 100 mM NaBH4. Immunolocalization was by the avidin--biotin immunoperoxidase method. Diabetic skin consistently stained more intensely for glucitollysine than nondiabetic skin. Staining around vessels, in particular, and of the collagenous matrix in general, was markedly enhanced in diabetic skin compared with nondiabetic skin. Antigens present in both the epidermis and the eccrine structures reacted with the antibody in both diabetic and nondiabetic skin but with greater intensity in the diabetic skin. This study has shown that it is possible to localize the early products of NEG in tissue sections using monoclonal antibodies. The findings correlate with biochemical data that show increased NEG in diabetics compared with nondiabetics. This technique should prove valuable for further investigations of the role of NEG in the pathogenesis of diabetes.
J Invest Dermatol 1989 Sep
PMID:A method for localizing the early products of nonenzymatic glycosylation in fixed tissue. 247 46

Carbohydrate metabolism has been examined in 301 patients with chronic pyoderma over the course of combined therapy including sugar-reducing drugs; biochemical methods (measurement of the blood sugar on an empty stomach, Staub-Traugott double carbohydrate load test, measurement of the blood serum seromucoid) and radioimmunoassay of the blood serum immunoreactive insulin have been employed. Diabetes mellitus has been first diagnosed in 2.9% of patients, latent diabetes in 18.8%, and in 4.7% of the examinees the parameters indicate the risk of this condition development. Combined therapy improves the examined parameters, providing good immediate and late results. These data favor the use of sugar-reducing agents in multiple-modality therapy of patients with chronic pyoderma.
Vestn Dermatol Venerol 1989
PMID:[Carbohydrate metabolism in patients with chronic pyoderma and its dynamics during therapy using sugar-decreasing preparations]. 258 84


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