Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recently, linkage between the ADA gene locus and MODY, a subtype of NIDDM, has been reported. The possibility that the region of chromosome 20q containing the ADA locus also may play a role in susceptibility to NIDDM needs to be investigated. Therefore, we examined the linkage between the ADA locus and NIDDM in affected siblings of 50 European white diabetic pedigrees--21 Italian and 29 British. Departure from independent segregation of the disease and an Alu VpA polymorphism within the 5' flanking region of the ADA locus was tested in the affected sib-pairs with the APM statistical method. After DNA amplification by the PCR and PAGE, five alleles were identified in the ALU VpA tract at the ADA locus in the two populations. Allele frequencies did not differ significantly between the two populations (chi 2 = 2.426, P > 0.05 [NS]). Analysis of the 50 diabetic sib sets, and independently of the Italian and British groups of affected sib pairs, revealed no segregation distortion between the marker locus and NIDDM. We conclude that mutations within or around the ADA locus are unlikely to play a major role in the etiology of NIDDM.
Diabetes 1992 Dec
PMID:Sib-pair analysis of adenosine deaminase locus in NIDDM. 144 5

72 patients with NIDDM (duration 5.3 +/- 3.1 years) aged 41-60 years were examined. They had also mild or moderate hypertension (duration 12.1 +/- 4.5). Control groups consisted of 15 NIDDM patients free of hypertension, 15 hypertensive patients without diabetes, 15 healthy subjects. All the patients have undergone 24-h monitoring of arterial pressure (APM) and computed cardiointervalography (CIG). As shown by CIG, hypertensive patients with NIDDM had sympathotonia which resulted from hypofunction of parasympathetic and hyperfunction of the sympathetic nervous systems. APM demonstrated enhanced variability of arterial pressure and its inadequate fall at night in patients of this group and normotensive patients with diabetes.
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PMID:[Vegetative regulation of arterial pressure in patients with arterial hypertension and non-insulin-dependent diabetes mellitus (NIDDM)]. 1068 15