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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 71-year-old woman complained of "smoky" vision, which was found to be caused by a hyphema with blood dripping from a vascular tuft located in the 12 o'clock meridian of the iris. Fluorescein angiography delineated vascular tufts and argon laser photocoagulation eradicated one of the tufts that bled. Histopathologic studies of iris obtained at the time of cataract extraction showed an aggregate of small vessels at the pupillary margin. Most patients with vascular tufts of the pupillary margin have no systemic disease but they are also observed in diabetes mellitus and myotonic dystrophy.
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PMID:Vascular tufts of pupillary margin of iris. 86 91

Variation in cell-surface sugar residues which exist between different pancreatic cells has been exploited in an attempt to isolate beta-cells from dispersed porcine pancreas utilizing selective lectin binding. The binding characteristics of a range of lectins were compared to determine their ability to differentiate between endocrine and non-endocrine cells in the porcine pancreas. Histological analysis showed that peroxidase labelled Arachis hypogaea bound selectively to islet cells in Carnoy-fixed sections of pancreas. In five experiments, porcine pancreas was dispersed into single cells by collagenase digestion, incubated with fluorescein isothiocyanate-labelled Arachis hypogaea and analysed using a Fluorescence Activated Cell Sorter. Fluorescein isothiocyanate-labelled Arachis hypogaea bound to a population of cells comprising 6% +/- 4.2% (mean +/- s.d.) of the total. Cells from representative samples were sorted into populations, based on fluorescence. Immunohistochemical analysis of the fluorescent populations showed that 93% +/- 2% of these cells contained insulin: none of the cells stained positive for glucagon or somatostatin. These preliminary studies show that it is possible to separate porcine beta-cells from a dispersed cell preparation using a fluorescent labelled lectin.
Diabetes Res 1991 May
PMID:Separation of beta-cells from dispersed porcine pancreas by selective lectin binding. 181 75

The present study was conducted on 25 patients with Diabetes Mellitus (DM) having positive indication of diabetic retinopathy on ophthalmoscopic examination. The patients were examined clinically, ophthalmoscopically and with Fluorescein Angiography (FA). It was found that the maximum number of patients with retinopathy were in their 5th and 6th decade and that retinopathy was more common in Non Insulin dependent diabetics (NIDDM) than Insulin dependent Diabetics (IDDM). It was also seen that retinopathy takes longer time to develop in IDDM patients (16.37 years vs 11.7 years). Proliferative diabetic retinopathy was more common with patients having poor glycemic control and in IDDM patients. FA was very helpful in detecting microaneurysms and for exact localization of neovascularization, and other microangiopathic lesions as well as for permanent record.
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PMID:Diabetic retinopathy: a clinical study with special reference to fluorescein angiography. 184 1

To identify more precisely the site and the nature of the abnormality of the Blood-Retinal Barrier (B.R.B.) in diabetes, quantitative fluorescence microscopy was used to measure time-dependent changes of fluorescence in ocular tissues of normal and diabetic rats, after intravenous fluorescein injection. Fluorescein distribution across the retinal layers was studied in control and streptozotocin diabetic rats at 5, 30 and 60 minutes after dye injection. Fluorescein intensities of choriocapillaris and retina were compared with plasma fluorescein levels. The results show a B.R.B. dysfunction in diabetic rats arising from abnormal leakage of fluorescein into the retina. After 60 minutes there was a greater fluorescence intensity localized to the inner retinal layers, consistent with a probable inhibition or saturation of active transport mechanisms for dye removal through the retinal vessels.
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PMID:[Microscopic quantification of fluorescein distribution in retinas of normal and diabetic rats]. 208 38

Seventy-two Type I diabetic patients were divided into three groups according to 24 hour urinary albumin excretion (UalbV, mean of three urine collections): normoalbuminuric group 1 (n = 49, UalbV less than or equal to 26 mg/24 h), microalbuminuric group 2 (n = 16, 26 less than UalbV less than or equal to 250 mg/24 h), proteinuric group 3 (n = 7, UalbV greater than 250 mg/24 h). Fluorescein angiography and three cardiovascular autonomic tests were performed. Relative frequencies of ocular findings (no retinopathy/simplex retinopathy/preproliferative and proliferative retinopathy) were determined in each group: group 1 (0.31/0.63/0.06), group 2 (0.56/0.38/0.06), and group 3 (0/0.43/0.57). The most severely affected autonomic function was observed in group 3 (p less than 0.01 vs. group 1). Significant partial correlations were found between UalbV and retinopathy (p less than 0.01), UalbV, and autonomic neuropathy (p less than 0.05), retinopathy and autonomic neuropathy (p less than 0.01), and blood pressure and UalbV and/or autonomic neuropathy (p less than 0.01). No correlation was found between the variables and the previous 15 months' metabolic control. The results suggest that nephropathy, retinopathy, and autonomic neuropathy are signs of a generalized diabetic microangiopathic process whose progression may be influenced by factors other than diabetes duration and metabolic control.
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PMID:Relationship between nephropathy, retinopathy, and autonomic neuropathy in patients with type I diabetes. 215 Dec 33

Fluorescein angiography was used to follow the development of retinal microangiopathy at the time of puberty in 34 children with type I diabetes. When the results were compared with those for the control children who had suffered from the disease for a similar length of time, it was concluded that (in contrast with certain literature data) the process of sexual maturation does not essentially influence the development of retinal microangiopathy if the diabetes is maintained under good control for a long-lasting period. Appreciable roles in the rapid progression that is frequently observed in early adulthood are attributed to the sudden changes in the previously systematic living conditions (school, family, etc.).
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PMID:[Effect of puberty on the development of diabetic microangiopathy]. 229 61

Carotid artery obstructive disease, although infrequently diagnosed as a primary or contributing cause of neovascular glaucoma, can produce distinctive characteristics. Decreased perfusion of the ciliary body may decrease aqueous humor production. As a result, such eyes with neovascular glaucoma may occasionally be normotensive or even hypotensive. Fluorescein angiography may show an increased arm-to-retina time and leakage from the major retinal arterioles. Panretinal photocoagulation may not eliminate the anterior segment neovascularization because of anterior segment ischemia. Endarterectomy can significantly increase intraocular pressure as perfusion to the ciliary body returns to normal. These characteristics were found in two patients, a 67-year-old woman and a 49-year-old man, with diabetes and hypertension. In both cases cyclocryotherapy significantly reduced the intraocular pressure and the rubeosis iridis regressed.
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PMID:Neovascular glaucoma and carotid artery obstructive disease. 240 76

Retinal status and glycosylated hemoglobin (GHb) was followed in 32 patients with insulin-dependent diabetes mellitus (18 females; age upon entering the study 26 +/- 8 years; duration of diabetes 10 +/- 6 years; means +/- SD) during a total of 136 patient-years, i.e. during 4.3 +/- 0.6 years per patient. Annual mean GHb (given in percent of the mean normal GHb) was calculated from 7 +/- 3 determinations of GHb per patient-year. Fluorescein angiographs were performed at least once per patient-year, and retinal status was assessed by counting microaneurysms. Upon entering the study, early diabetic (background) retinopathy was present in 14 patients; at the end of the follow-up period, it was present in 20 patients. Retinal status deteriorated in 4/42 patient-years with excellent metabolic control (annual mean GHb less than or equal to 125%), in 13/70 patient-years with good control (annual mean GHb 126-150%) and in 8/24 patient-years with poor control (annual mean GHb greater than 150%). The incidence rate of retinal deterioration differed significantly between years with excellent control and years with poor control (X2 5.7, df = 1, p less than 0.05). It is concluded that excellent metabolic control within 14 +/- 6 years after onset of insulin-dependent diabetes mellitus appears to be a protective factor against the development or progression of early diabetic retinopathy.
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PMID:Four-year follow-up of retinal status and glycosylated haemoglobin in patients with insulin-dependent diabetes mellitus. 341 Jan 51

The acute edematous capillaropathy of epipapillary and peripapillary radial vascolarization is an uncommon complication of type I Diabetes. Fluorescein angiography allows a reliable diagnosis to be made, because it provides good vision of the papilla and of the peripapillary posterior pole. The authors underline the importance of differential diagnosis because of the different therapeutic approach.
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PMID:[Papilledema in insulin-dependent patients]. 380 29

A review of 135 consecutive cataract operations identified ten cases (7.4%) of operating microscope light retinopathy. Ophthalmoscopically, these light retinopathy lesions appeared as a focal pigment epithelial change with varying degrees of pigment clumping in the center. Fluorescein angiography accentuated the lesion by demonstrating a sharply demarcated transmission defect, occasionally with multiple satellite lesions. The shape of the lesion matched the shape of the illuminating source of the particular operating microscope used during the surgery. The most significant risk factor associated with the production of these light retinopathy lesions was prolonged operating time. Mean total operating time for the ten patients with light retinopathy was 51 minutes longer than for those without (P less than .0001). Other significant associated factors were the presence of diabetes mellitus (P less than .03), younger age (P less than .05), and the use of hydrochlorothiazide (P less than .04).
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PMID:Incidence, risk factors, and morphology in operating microscope light retinopathy. 382 32


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