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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Strychnos potatorum Linn. seeds are used in the Indian traditional system of medicine for the treatment of hepatopathy, nephropathy, gonorrhoea, leucorrhoea, gastropathy, bronchitis, chronic diarrhoea, strangury, renal and vesicle calculi, diabetes and eye diseases. The present study describes the hepatoprotective and antioxidant activities of the seed powder (SPP) and aqueous extract (SPE) of Strychnos potatorum seeds against CCl4-induced acute hepatic injury. Hepatic injury was achieved by injecting 3 ml/kg, s.c. of CCl4 in equal proportion with olive oil. Both SPP and SPE at the doses 100 and 200 mg/kg, p.o. offered significant (p < 0.001) hepatoprotective action by reducing the serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT). They also reduced the elevated levels of ALP and serum bilirubin. Reduced enzymic and nonenzymic antioxidant levels and elevated lipid peroxide levels were restored to normal by administration of SPP and SPE. Histopathological studies further confirmed the hepatoprotective activity of SPP and SPE when compared with the CCl4 treated control groups. The results obtained were compared with Silymarin (50 mg/kg, p.o.), the standard drug. In conclusion, SPE (200 mg/kg, p.o.) showed significant hepatoprotective activity similar to that of the standard drug, Silymarin (50 mg/kg, p.o.).
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PMID:Studies on hepatoprotective and antioxidant actions of Strychnos potatorum Linn. seeds on CCl4-induced acute hepatic injury in experimental rats. 1638 23

This article considers the costs that arise in the context of the medical management of diabetes mellitus (DM) under different therapeutic regimes. The following evaluations were used in assessing these costs: the LIVE-KK study, a routine data analysis, the LIVE-SPP study, a medical practice data analysis and the LIVE-DE study (a medical practice data survey). Overall the available information indicates that the total cost of the treatment based on insulin gargine is comparable to that incurred with the NPH insulin-based treatment. The treatment showing a medical advantage is thus also the most cost-effective treatment. Another favourable aspect is that patients remain on the combination treatment of insulin glargine with oral antidiabetic drugs longer than is the case with the combination treatment of NPH insulin plus oral antidiabetics.
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PMID:[Current cost analysis in the management of diabetes mellitus]. 1868 19