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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a prospective, randomized study in 96 patients undergoing prostatic surgery (92 patients) and extensive transurethral bladder surgery (4 patients) all patients received postoperative antibiotics for five days. Following this the patients were divided into two groups. Group A received Bactrim for three months and Group B received a placebo for three months. Urine cultures were carried out six times during this three month period. In Group A, 13 patients (25%) were infected preoperatively and 9 patients (17%) postoperatively. In group B, 10 patients (22.8%) were infected preoperatively and 9 patients (20.5%) postoperatively. There was no significant difference between the results in the two groups. These and other results allow the following conclusions: 1. Routine postoperative long term treatment with antibacterial substances has no significant effect on the postoperative urinary tract infection. 2. Long term preoperative indwelling catheter treatment increases the incident of postoperative urinary tract infection. This can be prevented by operating patients early following the first urinary retention. It is confirmed that there is an increased risk of persistent urinary tract infection in patients with neurogenic bladder disturbances, preoperative ureteral dilatation, diabetes mellitus and various other complications.
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PMID:[The effect of long term antibacterial treatment following prostatic surgery. A comparative study in 96 patients]. 80 30

Since diabetics frequently suffer from urinary tract infections which can be successfully treated with a combination of sulphonamide derivatives and the bacteriocide trimethoprim, the question of possible interactions between such agents and diabetic therapy is of interest. A double-blind crossover trial was, therefore, carried out in 10 diabetics who were being treated with insulin, and 10 who were under treatment with sulphonylurea derivatives. Sulfametrol was administered in combination with trimethoprim (= Lidaprim). The blood glucose level was determined 3 times daily. No tendency towards hypoglycaemia was observed under treatment with the active agent in either group of patients. Within 5 days creatinine and blood urea nitrogen had increased to pathological levels in those patients who showed previous renal damage. It is concluded that the lack of interaction of these drugs with diabetes therapy justifies the use of these chemotherapeutic agents in diabetics. They are effective and relatively inexpensive in comparison with other agents. Subjective tolerance is also good.
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PMID:[An absence of interaction of sulfametrol-trimethoprim with insulin or sulphonylurea derivatives in diabetics (author's transl)]. 699 41