Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To study the urban-suburban differences in low birthweight among black Americans, 54,870 single births occurring to black mothers in the hospitals of Washington, DC, from 1980 to 1984 were analyzed. The observed data showed a 25% higher incidence of low birthweight (under 2501 gm) among infants born to urban mothers compared with those born to suburban mothers. Bivariate analysis showed that a greater proportion of urban mothers, compared with the proportion of suburban mothers, was teenage (23.6% vs 10.3%) and unmarried (67.6% vs 32.9%), had less than a high school education (31.7% vs 9.1%), and received inadequate prenatal care (34.3% vs 20.3%). The logit model fit to these data showed that by controlling for the above risk factors, the residential differences in the incidence of low birth rate were almost eliminated. Exploration of the medical risks associated with adverse pregnancy outcomes showed that the urban mothers had substantially higher rates for premature rupture of membrane, concurrent hypertension, pre-existing diabetes, hyperemesis, anemia, and narcotic addiction. The findings of the article underline the usefulness of studying intra-black differences rather than relying solely on race comparative research.
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PMID:Urban-suburban differences in the incidence of low birthweight in a metropolitan black population. 278 47

The patient was a 37-year-old female teacher with hyperemesis diabeticorum and juvenile Type-I diabetes. At the age of 29 years, nausea and vomiting developed and secured at nearly weekly intervals. She was started on clotiazepam (15 mg/day). The vomiting was cured and psychological improvement was evident; her anxiety about diabetes was markedly reduced. An X-ray examination after the administration of clotiazepam showed that she was entirely free from marked hypoperistalsis and the severe retention of gastric contents which had been present before this treatment. The present case is a clear example of stress closely related to the pathogenesis of hyperemesis diabeticorum.
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PMID:Influence of an antianxiety drug on hyperemesis diabeticorum. 612 62

Controlled labor-caused fetal stress during birth can be tolerated better than generally suspected. This is the result of a pilot study among 1000 term infants in which the postpartum development of neonate weight was evaluated as a simple parameter of adaptation to extrauterine life. I. The clinical relevance of postpartum weight development was demonstrated in newborns whose mothers had been hospitalized during pregnancy e.g. because of hyperemesis, diabetes or gestosis. Postpartum these newborns showed longer lasting and more extensive weight loss. II. On the contrary moderate fetal stress during labor results in less and shorter lasting weight loss of the newborn term infants born after a labor-period of 12 hours showed a weight loss greater than 5% of their birth weight. Only half as often as newborns after a shorter period of labor. Further parameters of stress like a 1 minute APGAR score up to 6 versus 1 minute APGAR between 8 and 10 or umbilical cord ph-values below and over 7.20 revealed the same tendency. Newborns with green amniotic fluid (as a sign of stress) during birth also had a lower weight loss (up to 2% of birth weight) twice as often as newborns without green amniotic fluid. A statistically significant relation was also seen between the way of delivery as another aspect of stress and postpartum weight: on the 5th day postpartum newborns delivered by cesarean section showed a weight below birth weight three times as often as babies delivered by vaginal-operation means. The evolutionary aspect of catecholamine-peak during birth as protection against labor-induced hypoxemia and as advancing factor of adaptation to extrauterine life makes the results of this study seem plausible. This topic deserves more clinical research.
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PMID:[Evolution promotes a minimal effect of fetal labor stress during birth]. 930 86