Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An analysis of 1,600 consecutive treadmill exercise tests is made, with emphasis on those with an ischaemic response. An ischaemic response is defined as a horizontal or downsloping depression of the ST segment of 1 mm or more. A hypertensive response is recorded where the blood pressure exceeds 200 mm Hg systolic or 100 mm Hg diastolic during exercise. There were 150 (9%) ischaemic responses and 279 (17%) hypertensive responses. Cardiac arrhythmias were detected in 173 (11%) subjects. Among the 150 subjects with ischaemic responses, 69 (46%) of them presented with anginal symptoms while 64 (43%) of them had no precordial pain. Twenty-seven (18%) of them had definite previous myocardial infarction. Risk factors observed included hypertension in 54 (36%) subjects, diabetes mellitus in 33 (22%) subjects, hypercholesterolaemia in 41 (37%) out of 112 subjects and 44 (29%) cigarette smokers.
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PMID:Treadmill exercise testing in ischaemic heart disease. 368 10

24 cases of cardiac rupture (CR) (12%) were found in 200 necropsies of patients who died from acute myocardial infarction (AMI). Examination of the various factors that may affect the onset of this complication showed that age, sex, the site of AMI, the presence of coronary thrombosis, the association of persistent arterial hypertension, diabetes mellitus or previous angina syndrome and anticoagulant and corticosteroid treatment are insignificant. On the other hand, previous myocardial infarction would appear to reduce incidence considerably. CR was much more frequent in the first 3-4 days after onset of AMI and never occurred more than 21 days after. An important premonitory sign is persistent precordial pain in the absence of pericardial friction. Cardiokinetic therapy was used in 70% of the CR cases examined here. Over the past decade, the frequency of CR secondary to AMI has risen appreciably and it is hypothesised that this increase may have been influenced by the readiness with which cardiokinetics are employed now during AMI, often in very high doses. Particularly in the case of patients at high CR risk, it is considered that cardiokinetic therapy should only be employed in cases of clear cardiac insufficiency, in small, fragmented doses and after diuretics and vasodilators have proved ineffective. Such patients can also usefully be transferred to specialist wards for emergency surgery or preventive infarctectomy.
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PMID:[Heart rupture in acute myocardial infarct]. 721 92