Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The patient was a 63-year-old male. He was diagnosed as having diabetes mellitus in 1987, and hemodialysis was begun in October 1991 for diabetic nephropathy. He complained of glans pain from the middle of May 1992. Although he was administered antibiotics, a small ulcer arose on the glans penis at the end of May. The lesion became progressively black and carbonized on the whole glans penis by the first of June and involved the prepuce by the end of June. Partial penectomy was performed in July. Histopathological examination showed marked stenosis with calcification in the terminal branches of the dorsal penile artery and thickened wall of the small arteries due to vascular lesions as a result of diabetes mellitus. The patient was in generalized deterioration of clinical condition postoperatively and died of gastrointestinal bleeding in September. Penile necrosis in patients with diabetes mellitus is very rare and only ten cases including our own case have been reported. We reviewed the literature with special reference to the relationship with chronic renal failure.
 ...
PMID:[A case of penile necrosis in a patient with diabetic nephropathy]. 810 82

Distal penile necrosis associated with renal failure is a rare entity; only a few cases have been reported in the literature. Penile necrosis can frequently be a difficult management problem, the etiology of which is infectious, traumatic, or vascular. Physiological abnormalities are usually found in association with this condition, including diabetes, hyperparathyroidism, and peripheral vascular disease. Penile necrosis is a poor prognostic factor associated with high morbidity. We report two cases of this condition, presenting the clinical and pathophysiological background.
 ...
PMID:Two cases of penile necrosis in diabetics with end-stage renal failure. 1199 74

The penis is provided with blood by multiple arteries. Penile necrosis is uncommon. Penile necrosis sporadically occurs in patients with progressive diabetes mellitus and/or end stage renal failure. Penile necrosis is often considered a poor prognostic feature. We present a case of penile necrosis in a patient with mild diabetes mellitus.
...
PMID:[A case report of progressive penile necrosis]. 2489 63

Penile necrosis is a rare condition that has been mostly described in association with diabetes mellitus and end-stage renal disease. We report an unusual case of acute penile necrosis because of heparin-induced thrombocytopenia. A 75-year-old man presented with acute renal failure and experienced cardiac complications during the hospitalization. The patient was treated twice with intravenous heparin. He developed symptoms of penile necrosis 4 days after the reintroduction of heparin. At that moment, the platelet count dropped by 61%, and the analysis of heparin-pf4 antibodies was positive for heparin-induced thrombocytopenia. The patient underwent a total penectomy and a perineal urethrostomy.
...
PMID:Complete Penile Necrosis in a Patient With Heparin-induced Thrombocytopenia: A Case Report. 2695 36

Background: Penile necrosis is a rare condition that may present in patients with diabetes mellitus or chronic kidney disease (CKD). The recommended treatment is controversial. We report a case of penile necrosis in a diabetic patient caused by episode of paraphimosis associated with uremic arteriopathy treated with partial amputation. Clinical Case: A 53-year-old male with a background of arterial hypertension, diabetes mellitus and CKD in hemodialysis. The patient presented with paraphimosis and glans necrosis. An emergency circumcision was carried out. A doppler ultrasound found fluid collection in the left corpus cavernosum, parietal vascular calcifications and vascular insufficiency in the corpus cavernosum that suggested necrosis. A partial amputation of the penis was carried out. After three years of follow-up, the outcome has remained favorable. Conclusions: Penile necrosis is a rare but serious complication of terminal CKD. In these patients, systemic calciphylaxis is usually observed. The main take-away lesson is that a multidisciplinary approach is necessary.
 ...
PMID:Case Report: Penile necrosis associated to paraphimosis with calciphylaxis due to terminal chronic kidney disease. 3144 10