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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A histomorphological and ultrastructural analysis of the adaptation reaction of the rat heart muscle during an early experimental alloxan diabetes has been carried out. Changes were observed in the orthomorphology of the ultrastructure which appeared as vesicular intercalated discs within the fasciae adherentes regions, as changes in the mitochondria, cell nucleus, myofibrills and in the sarcoplasmic reticulum with a simultaneous increase in the number of lipid bodies. The described alterations are dependent on the duration time of the experiment and on the disturbances in the entire and local system cellular metabolism.
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PMID:Histomorphological and ultrastructural studies of a rat myocardium in experimental conditions. 103 42

For a period of two days, while maintaining compensation of diabetes mellitus type I (treated by insulin pump), the authors replaced the usual diabetic diet by a bland carbohydrate diet (2.6 +/- 0.6 MJ/24 h, practically without amino nitrogen). This resulted in a negative energy and nitrogen balance with an indicated adaptation reaction on the second day of administration--reduced amount of catabolic urinary nitrogen, concentration of non-esterified serum fatty acids suggested a slightly increased lipolysis. The insulin consumption per 24 h was significantly reduced, as compared with the control day. A low energy carbohydrate diet is, when administered for a short period under careful control of compensation of diabetes type I, relatively safe and can be used e. g. during intercurrent digestive diseases.
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PMID:[Variations in the dietary regimen in type I diabetes mellitus. I. Short-term use of a high-carbohydrate diet]. 201 72

Instability of the system of detoxication of peroxidative products and system of generation of free-radical oxidation of membrane lipids in placenta, funic blood, in amniotic water of mothers with diabetes mellitus and in newborns blood has been found. It is shown, that the exhaustion of antioxidative status of fetoplacental complex connected with the depression of antioxidative activity in blood of the newborns reflects the frustration of adaptation reaction of the newborn's organism, that may increase the risk of perinatal diseases or mortality.
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PMID:[Role of antioxidant enzymes of the fetoplacental complex in neonatal adaptation to maternal diabetes mellitus]. 799 48