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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)

A significantly lower vitamin C concentration has been found in the blood and particularly in the leukocytes of hypercholesterolemic diabetic patients than of healthy blood donors. Ascorbic acid administered in a dose of 500 mg per day for 12 months to metabolically stabilized hypercholesterolemic subjects with maturity-onset diabetes mellitus (diabetic diet without insulin or diabetic drugs) brought about a striking decline of cholesterolemia and a moderate decline of triglyceridemia. The serum lipid level in the control group given placebo remained unaltered. A daily administration of 500 mg of ascorbic acid for six months failed to affect the fasting level of serum immunoreactive insulin. It is assumed that the long-term administration of ascorbic acid to maturity-onset diabetics removed the tissue ascorbate deficiency and improved the liver ability to compensate the increased endogenous synthesis of cholesterol by its enhanced transformation to bile acids.
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PMID:Hypocholesterolemic effect of ascorbic acid in maturity-onset diabetes mellitus. 36 79

The authors present the results of studying immunoglobulins of classes A, M, and G in 40 children with diabetes mellitus; immunoglobulin level was analyzed depending on a number of clinical diabetes mellitus indices and insulin antibody titres. The III type of dysgammaglobulinemia was found to be characteristic of patients with microangiopathies; changes in the immunoglobulin content were directly opposite to the changes revealed in patients with microangiopathies. With increasing the duration of diabetes there was an aggravation of dysgammaglobulinemia characteristic of these two groups of patients. The level of immunoglobulins under study was greater in the patients with lipoatrophies and in those without any hereditary predisposition to diabetes than in patients without lipoatrophies and without any hereditary predisposition to diabetes, respectively. A regular reduction of all the immunoglobulins level was observed only in patients with glucosuria of not less than 100 g/24 hours. Immunoglobulin content showed no significant association with the patients' sex, age, the insulin antibody titre, and the age at which diabetes developed, or with hyper cholesterolemia and enlargement of the liver.
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PMID:[Serum immunoglobulins in children with diabetes mellitus]. 41 19

Lipoprotein metabolism was studied by analyses of apolipoproteins, cholesterol content in lipoproteins and electrophoresis. The findings obtained suggested that the apolipoprotein levels such as A1 and B are related with particle number of lipoproteins such as HDL and LDL, while cholesterol content in lipoproteins is affected by qualitative change in particles as well. In patients with diabetes mellitus (NIDDM), LDL cholesterol correlated with HbA1c, and cholesterol and apolipoprotein B in the beta-area on electrophoresis showed accelerated mobilities, which were mimicked by in vitro glycation of LDL. In coronary heart diseases, elevation of apolipoprotein B and a low level of HDL cholesterol were general findings. The B/A1 ratio could be a sensitive indicator for these diseases. Hyper HDL cholesterolemias, excluding the patients with prostatic cancer who had undergone estrogen-treatment, showed elevated levels of apolipoprotein E in alpha 2-area on electrophoresis. Heterogeneity in Hyper HDL cholesterolemia was implicated. Qualitative analysis of lipoproteins by our method is believed to be useful.
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PMID:[Lipoprotein metabolism analysis in arteriosclerotic diseases]. 226 73

The prevalence and clinical aspects of high-HDL-cholesterolemia were investigated in 2000 patients (1215 males and 785 females) aged 14-88 years in our medical outpatient department. The incidence of high-HDL-cholesterolemia was 7% (greater than 1.68 mmol/l) in males and 9.9% (greater than 1.94 mmol/l) in females and was associated in 80% of cases with a normal lipid profile according to the Fredrickson classification. Compared with patients with low-HDL-cholesterolemia, high-HDL-cholesterolemia distinguished by a lower incidence of obesity, of hyperlipidemia, of diabetes and of cigarette smoking. In contrast, daily alcohol intake was significantly higher. Fewer patients had a history of ischemic cardiovascular events. High-HDL-cholesterolemia appears to arise from both environmental and genetic factors.
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PMID:[Hyper-HDL-cholesterolemia: prevalence and clinical aspects]. 260 37

A micromethod adapted for automated determinations was used to measure basal plasma levels of homocyst(e)ine [H(e)]. These levels included the sum of free and bound forms of homocysteine, its disulfide oxidation product, homocystine, and the homocysteine-cysteine-mixed disulfide. Two groups of subjects were studied: apparently healthy individuals (n = 103) and patients with peripheral arterial occlusive disease (PAOD) (n = 47). Because age in PAOD patients was higher than in control subjects, the control subjects were subdivided into younger and older groups (aged 60 years or less and more than 60 years, respectively). The H(e) levels in the younger groups were 11.18 +/- 3.58 (mean +/- SD, expressed as homocysteine) and 8.58 +/- 2.82 nmol/ml in men and women, respectively; in the older groups, the levels were 10.74 +/- 2.16 and 9.04 +/- 2.16 nmol/ml in men and women, respectively. There was a positive correlation of H(e) levels with age in the younger control women (r = 0.373; p less than 0.02); no significant correlations were present in the other three control groups. Levels of H(e) in PAOD patients (15.44 +/- 5.76 and 17.04 +/- 8.26 nmol/ml in men and women, respectively) were significantly higher than those indicated above in the older controls. Next, the PAOD patients were assigned to two subgroups: 1) those with normal levels of H(e) (within two standard deviations of the mean of the control values) and 2) those with elevated levels of H(e). Age, cholesterolemia, and the prevalence of smoking and diabetes were similar in both subgroups. These results suggest that elevated plasma H(e) is an independent risk factor for arterial occlusive disease.
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PMID:Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease. 278 71

This study was undertaken to ascertain a clinical impression that the prevalence of complications is higher in insulin-dependent Algerian diabetics than in their European counterparts. Forty-one Algerian patients under regular follow-up for 2 years or more were closely matched to 41 French insulin dependent diabetics with regard to sex (34M/7F) and duration of disease (10.5 +/- 1 year; range 2 -32 years). Insulin dose, number of injections, arterial blood pressure, glycemia, glycosylated haemoglobin, cholesterolemia and triglyceridemia were similar in the two groups. The age at the time of diagnosis of diabetes was higher in the Algerian group (28.7 +/- 1.9 vs 21.4 +/- 1.7) as was the number of smokers (23/41 vs 12/41). No difference was noted between the two groups with respect to the prevalence of retinopathy (absent, simple, proliferative): 25, 12, and 4 vs 29, 9, and 3 or nephropathy (absent, incipiens, patent): 30, 6, 5 for the Algerians and 35, 3, 2 for the French. This suggest that long term metabolic control was relatively identical in the two groups. The incidence of neuropathy rated as absent, moderate (abolished reflexes, impaired pallesthesia, cardiac neuropathy) or severe was significantly higher in the Algerians (13, 16 and 12) as compared to the French (28, 10 and 3) p less than 0.01. Severe neuropathy in the Algerian group was often multiple (8/12), serious and early. The only difference between the neuropathic and non-neuropathic Algerian subgroups was the duration of disease (13.2 +/- 2.2 vs 7.3 +/- 0.01; p less than 0.01). Since there were apparently no acquired nutritional factors, an ethnic predisposition of Algerians to develop neuropathy seems likely.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Increased prevalence of neurologic complications among insulin dependent diabetic patients of Algerian origin. 324 88

The study includes 6243 persons--4051 women and 2192 men, mean age 37.9 +/- 14.2 years. The total serum cholesterol was examined and the factors related to the cholesterolemia were studied. A strong statistical correlation was found between the cholesterolemia and age, sex, body mass, smoking, degree of physical activity, alcohol consumption, feeding and diabetes mellitus. This multifactorial correlation of cholesterol serum level determines the need of complex population measures for reducing the high cholesterol level by correction of the mode of feeding and living and counteraction of the harmful habits (smoking), overfeeding, physical hypodynamia.
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PMID:[Effect of various factors on total serum cholesterol based on the data from an epidemiologic study in 4 large communities of Bulgaria]. 324 10

The presence of a diagonal ear lobe crease (DELC) was studied in 350 non-selected patients admitted to the Clinic. The overall incidence of DELC was 45%, with a significant increase after the age of 50 years (24.8% before and 59.5% after fifty, p less than 0.001). The relationship between DELC and ischemic chronic heart disease (65% as against 23% in the patients without DELC, p less than 0.001) and with some coronary risk factors: arterial hypertension (40% in patients with DELC, 29% in those without, p less than 0.01), smoking (43%) as against 35% in those without DELC. The relationship with diabetes mellitus and obesity was not significant. A higher incidence of DELC was observed in males (66%) than in females (34%) (p less than 0.02). The lipid profile of patients with DELC presents significant cholesterolemia changes (251 +/- 71 mg as against 232 +/- 70 mg in those without DELC) and a less marked increase in lipemia and beta-lipoproteins. All risk factors presented a net increase in the subjects with bilateral DELC. It is concluded that DELC can be used for selecting asymptomatic subjects in the screening of a possible coronary heart disease.
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PMID:Relation between diagonal ear lobe crease and ischemic chronic heart disease and the factors of coronary risk. 372 21

The authors address the two following questions: 1) Is detection of glycoregulation disorders possible from data yielded by routine annual examination (7,923 subjects)? 2) Do further investigations, carried out in a subdivision of subjects selected according to the risk of cardiovascular disease (n = 1,232), show a difference in the distribution of risk factors and risk indicators between patients and "healthy" individuals? Analysis of the results of this transversal study demonstrates a fact that is well-known concerning diabetes: even mild hyperglycemia (greater than or equal to 6 Mmol/l) is significantly correlated to age, excess weight and high systolic blood pressure. In both male and female subjects, there is a strong correlation between mean blood glucose concentration and the other biologic parameters that were studied (blood pressure, serum cholesterol, LDL/HDL cholesterol). Conversely, no correlation was found with smoking habits or with the intake of various dietary components. These results indicate that age, excess weight and increased blood pressure are simple data which are suggestive of abnormal glycoregulation. Comparison of risk factors and risk indicators in patients and "healthy" subjects showed significant differences for age, smoking habits and systolic blood pressure only. Glycemia, cholesterolemia and obesity were similar in both groups. These findings are evidence of the high risk in the subjects considered as "healthy", in whom the degree of atherosclerosis cannot be ascertained. Atherosclerosis in "healthy" individuals can certainly not be overlooked: in subjects with normal blood pressure, fundus examination showed a similar proportion of abnormalities in patients and "healthy" individuals.
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PMID:[Screening for blood glucose abnormalities and coronary heart disease through routine annual examination (author's transl)]. 628 34

The measurement of HbA1 gives an "objective" estimate of the degree of metabolic control of diabetes during the erythrocyte lifespan. 333 assays in 85 young diabetics aged three to twenty-three years showed a mean HbA1 of 10.9 +/- 2.6% (controls: 7.4 +/- 1.4%). HbA1 levels parallel the clinical evaluation of the degree of control. HbA1 concentrations are correlated with the duration of diabetes (r = 0.26; p less than 0.001), triglyceridemia (r = 0.22; p less than 0.001), cholesterolemia (r = 0.26; p less than 0.001) and glycemia (r = 0.50; p less than 0.001). The HbA1 glycemia correlation grows stronger as glycemia increases. This probably reflects the existence of a labile form of HbA1. HbA1 concentrations measured repeatedly over one year were not significantly different in diabetics with and without retinopathy, probably because the study period was too short. Measurement of HbA1 is also of value in diagnosing non-compliance.
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PMID:[Glycosylated hemoglobin and clinical evaluation of the degree of diabetes control. Relation to blood sugar, blood cholesterol, blood triglycerides, and the duration of diabetes and retinopathy. Study of 85 diabetic children and adolescents]. 630 Oct 21


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