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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In view of some data of the literature suggesting that immunological changes could play a role in the pathogensis of diabetes mellitus and of its complications, we carried out a study of the lymphocyte populations of 44 diabetic subjects by means of E, EA, EAC rosettes and membrane immunofluorescence. A quarter of the patients had decreased E rosettes: all of these had long-lasting, insulin-dependent, poorly controlled diabetes. Some of these patients had also increased membrane IgG globulins. In 5 patients with recent onset, insulin-independent diabetes, E rosettes were increased. No significant changes of EA and EAC rosettes were observed. These findings suggest that changes of lymphocyte populations do not play any role in the pathogenesis of diabetes, while these may be the consequence of the metabolic disorder and these may favour the onset of complications of the disease.
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PMID:[Immunological changes in diabetes mellitus. Study of lymphocyte populations]. 31 18

Cholesteatoma of the EAC is a rare otologic problem, particularly when keratosis obturans otica is excluded. The predominant features of EAC cholesteatoma are acute external symptoms, severe pain, recurrent physician visits, and paucity of X-ray findings. Poorly responding otitis externa should always alert the physician to the possibility of neoplasm, diabetes, or some other underlying condition which will not respond to just topical treatment. Cholesteatoma of the external auditory canal should also be considered in refractory cases of otitis externa. Three patients with EAC subperiosteal cholesteatoma are reviewed.
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PMID:External auditory canal cholesteatoma. 73 64

The count of peripheral neutrophils having the superficial receptors for Fc IgG fragment (FcR) and C3 component of the complement (CR) was determined in diabetic patients by using the rosette tests EA and EAC according to the modified Buescher method. A significantly lower percentage of neutrophils with FcR and CR receptors was found in patients with both insulin-dependent and noninsulin-dependent diabetes. The lowest values were found in noncompensated diabetes; in compensated diabetes they were higher but still significantly lower than in the controls. The difference was significant in both tests used. The results obtained suggest that the observed fall in the percentage of neutrophils with FcR and CR receptors is caused by metabolic disturbances associated with diabetes.
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PMID:[Behavior of granulocytic receptors for Fc IgG fragment and C3 component of complement in patients with diabetes]. 136 95

This study examined the effect of experimental diabetes mellitus on the dorsal tongue of rats which were made diabetic by tail-vein injections of streptozotocin (50 mg/kg) and then raised for either 5 or 10 months. Lingual papillae were observed by scanning electron microscopy (SEM) and light microscopy. Morphological changes in lingual mucosal capillaries in 10-month diabetic rats were observed by electron microscopy (TEM). In the study of cellular movement in the lingual dorsal epithelium, bromodeoxyuridine (BrdU) was applied as a tracer for studying DNA replication. In diabetic rats, lingual papillae showed morphological atrophic changes. The lingual mucosal capillaries' alterations included endothelial cells with numerous cell projections into the lumen, degenerated cell organs, increased basement membrane width, and narrowed capillary lumen. BrdU labeling index among the basal cells was reduced in diabetic rats which indicates a possible retardation of their epithelial-tissue activity. In diabetes mellitus, direct metabolic disturbances to the epithelia because of insulin deficiency first occurred, successively diabetic microangiopathy appeared on the lingual mucosal capillaries. The appearance of diabetic microangiopathy caused tissue hypoxia, which induced atrophic changes to the epithelia.
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PMID:A histological study of changes in the lingual papillae of streptozotocin-induced diabetic rats. 142 10

The study has been aimed at comparison of the number of peripheral blood mononuclear white cells in the E. SRBC, EA, EAC, SIg markers in patients with insulin dependent (type 1) and non-insulin dependent (type 2) diabetes and healthy donors. There was no marked difference in the numbers of surface markers E SRBC and SIg among the 3 groups. Significant increase in the number of cells with markers: FcIg and C3 fragment of complement was noted in patients with diabetes type 1 and type 2. No relation between the number of mononuclear cells in peripheral blood and the blood glucose level was observed.
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PMID:[Effect of metabolically uncompensated diabetes mellitus on mononuclear cell populations in peripheral blood]. 152 56

The study material comprised 60 patients treated at the Clinic of Ophthalmology PMA in Szczecin, in the years from 1981 to 1984 due to uveitis. In the patients routine laboratory examinations were performed and extended by additional ones in the direction of diseases being of rheumatoidal type, tuberculosis, toxoplasmosis, diabetes and focal infections. All the patients had rosette tests of E, EA, EAC prior to treatment and after 30 days of therapy. The patients were divided at random into 2 groups with 30 persons each. Apart from typical treatment for uveitis the group I was given the FIBS preparation. The clinical picture failed to reveal any significant differences between the groups of patients. It was observed that the count of lymphocytes T and B in the peripheral blood was disturbed. After the applied treatment changes were recorded in the count of lymphocytes T and B, the shiftings in the group of patients, having been treated with FIBS, were marked more distinctly, particularly in the count of lymphocytes T.
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PMID:[Evaluation of the effect of treatment with FIBS preparation on the clinical state and various parameters of the immune system in patients with uveitis]. 263 96

The ultrastructure of the visceral yolk sac endoderm of in vivo developing 9- to 13-day-old embryos from 2 diabetic rat models (streptozotocin diabetes and Cohen--genetically determined--diabetes) and from nondiabetic rats fed high sucrose diets have been studied. This was compared to yolk sacs from 9.5-day-old embryos cultured for 48 h in sera from diabetic and nondiabetic rats fed a high-sucrose diet. Light-microscopic, TEM and SEM studies showed that the pathological cellular changes in the visceral yolk sac endoderm from diabetic rats were first observed on day 9 and were most severe among 11-day-old embryos. In vitro culture of control rat embryos in serum from experimental animals induced a reduction in the number of microvilli, of vacuolar intracellular inclusions and an increase in the number of degenerated endodermal cells. SEM studies showed that in addition to disappearance of microvilli, the majority of cells were collapsed and had degenerated cell membranes. Culture of embryos from diabetic animals in control serum only slightly reversed the pathological changes in the visceral yolk sac endoderm. A good correlation exists between the rate of embryonic malformations in diabetic rats and an index of endodermal-cell damage in the visceral yolk sac.
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PMID:The effects of high-sucrose diets and of maternal diabetes on the ultrastructure of the visceral yolk sac endoderm in rat embryos developing in vivo and in vitro. 295 Jul 13

Increasing interest in animal models of human nephropathies have led to a number of renal studies in nonhuman primates. In the current investigation, sequential detergent extraction of cellular elements was carried out on renal cortical tissue blocks from rhesus monkey in an effort to demonstrate clearly the morphological features of major basement membrane (BM) types and their associated extracellular matrix (ECM). LM and TEM views of acellular tissue blocks demonstrate planar arrangements of ECM components, while SEM studies provide striking three-dimensional images of their surface characteristics. All major BM types maintain their in vivo histoarchitectures despite the absence of cells. We propose that the intrinsic structural rigidity of tubular (TBM), Bowman's capsule (BCBM) and peritubular capillary BM (PTCBM) may be related to to their close external association with collagenous fibrils, while glomerular BM (GBM) may be internally supported by a network of mesangial matrix (MM) plates and trabeculae which extend onto internal surfaces of peripheral GBM loops. Thicknesses of rhesus monkey renal BMs show that they are similar to those seen in the laboratory rat and, in general, BCBM greater than TBM greater than GBM greater than PTCBM. We conclude that rhesus monkey renal BMs closely resemble those described by us in the human [J. Ultrastruct. Res. 82: 96-110, 1983] and that this species offers an attractive model for studies of renal diseases of BM origin-notably diabetes mellitus.
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PMID:Ultrastructural analysis of major basement membrane types in rhesus monkey Macaca mulatta acellular renal cortex. 351 73

Because of its general effects on connective tissue metabolism diabetes mellitus is becoming more and more important in the orthopaedic field. For investigation of morphologic changes in the cartilage a model of streptozotocin-induced diabetes was used in 80 rats. Studies were performed by light-, scanning- and transmission-electron microscopy and by biochemical analysis of proteoglycan and collagen metabolism. Three months after onset of diabetes the chondrocytes show increased metabolic activity and at the same time first stage regressive changes. The morphologic changes correlate with a significant decrease of hexosamine content in the cartilage. There is no evidence for any disturbance of collagen metabolism at that time. After seven months the cartilage is widely necrotic, the collagen fibers are swollen and show almost total loss of their microstructure. There is no sign for reparation of the necrotic zones at this time. It is most remarkable that in many specimen crystal deposits are found just below the cartilage surface which from the TEM-findings look very much like calciumpyrophosphate crystals. The morphologic and biochemical results show that in the rat diabetes leads to a special type of cartilage changes with crystallic arthropathy which seems to be a valuable model for the study of metabolic osteoarthrosis.
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PMID:[Morphological and biochemical studies of the cartilage in the diabetic rat--a model for metabolism-induced arthritis]. 371 47

Investigations on the T and B lymphocyte surface architecture were carried out by means of scanning electron microscopy (SEM) in 102 patients with various chronic internal diseases such as chronic hepatitis, diabetes mellitus, systemic lupus erythematosus, chronic lymphocytic leukemia, a.o. The clinical and biological examination performed in these cases reveled also some cytochemical, biochemical and immune disturbances. Emphasis is laid on the superiority of SEM, as compared with the E and EAC rosette tests, for the identification of T and B lymphocytes. Moreover, by detecting certain cellular anomalies, SEM can provide useful indications regarding the diagnosis, prognosis and therapy of the above mentioned diseases. Association of SEM with other clinical and laboratory investigations can either confirm, disapprove or even enhance the value of the morphological findings by electron microscopy.
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PMID:Aspects of the T and B lymphocyte surface architecture in chronic internal diseases with immune component. Scanning electron microscopy studies. 696 86


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