Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diabetic cystopathy (DCP) is a well known complication in diabetes mellitus (DM). In the present experimental study, DM was induced in rats by streptozotocin and DCP was confirmed on cystometry. In vitro studies on detrusor strips from diabetic rats showed an increased contractile response to substance P (SP) compared with controls, indicating denervation supersensitivity. A decreased response to capsaicin in diabetic detrusor strips indicated a decreased neuronal content of SP or a diminished number of SP-containing sensory nerves. This suggests that DM induces alterations in nerves containing SP which may be at least partly responsible for sensory loss and the development of DCP.
 ...
PMID:Effect of substance P on detrusor muscle in rats with diabetic cystopathy. 128 May 13

Diabetic cystopathy refers to the spectrum of voiding dysfunction in patients with diabetes mellitus. Diabetic cystopathy is marked by insidious onset and progression with minimal symptomology. The most common urodynamic findings are impairment of bladder sensation, increased post-void residual volume, decreased detrusor contractility that may progress to detrusor areflexia and diminished urinary flow. Treatment of diabetic cystopathy may be complicated by frequently occurring coexisting urologic conditions. The most common of these is bladder outlet obstruction. Therefore, treatment of diabetic cystopathy should be tailored to the symptom complex and clinical condition of the patient. Asymptomatic patients with manifestations of diabetic cystopathy may be treated with timed voiding. In contrast, the sine qua non for therapy in symptomatic patients is clean intermittent catheterization. While other modalities such as pharmacologic and surgical intervention have been described, none have been consistently effective.
 ...
PMID:Diabetic cystopathy. 297 63

Diabetic cystopathy is a common complication of diabetes mellitus, but little is known of the mechanisms responsible for the bladder dysfunction. Therefore, the effect of streptozotocin-induced diabetes on urinary bladder function was investigated. Bladders from 2-month diabetic rats were significantly larger than those from age-matched controls. Protein concentrations in bladder body and base were similar in diabetic and control rats. However, due to the greater bladder body weight in diabetic animals, total protein content of bladder bodies from diabetic rats was significantly greater than those from controls. Contractile responses of strips obtained from bladder body and base to stimulatory agents and nerve stimulation were altered by diabetes. In bladder bodies from diabetic rats, the maximal contractile responses to nerve stimulation, acetylcholine and KCl were reduced compared to controls. In addition there was a decreased sensitivity to acetylcholine and KCl in the diabetics. In contrast, with strips from bladder base there was a decrease in sensitivity to nerve stimulation in the diabetic rats, but no change in sensitivity to norepinephrine, acetylcholine, ATP or KCl. The maximal contraction by bladder base in response to norepinephrine was decreased in diabetic rats, but there was no change in maximal contraction by bladder base in response to norepinephrine was decreased in diabetic rats, but there was no change in maximal response to nerve stimulation, acetylcholine, ATP or KCl. These results indicate that a relatively nonspecific decrease in the responsiveness of bladder body is caused by diabetes, but agonist-specific changes are produced in bladder base.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Abnormalities of rat bladder contractility in streptozotocin-induced diabetes mellitus. 374 63

The precise incidence and prevalence of diabetic cystopathy are difficult to determine because of the insidious onset, discrete symptoms, and differences in the definition of bladder dysfunction. Diabetic cystopathy, classified according to urophysiological criteria, was shown to occur in 43% to 87% of insulin-dependent diabetics, with no sex or age differences. Another study showed an average 25% prevalence of diabetic cystopathy in patients on oral hypoglycemic treatment. A Scandinavian study showed that in patients who have had diabetes for 10 years, the prevalence of diabetic cystopathy in those who were insulin-dependent was two to four per 1000 and in those on oral hypoglycemic agents was one to three per 1000. The correlation between diabetic cystopathy and peripheral neuropathy ranged from 75% to 100%. Nephropathy was seen in 30% to 40% of cases. The higher frequency of urinary tract infections in diabetics is not related to diabetic cystopathy but to the frequent occurrence of non-neurogenic bladder outlet disorders, especially in older women.
 ...
PMID:Diabetic cystopathy: epidemiology and related disorders. 735 21

Diabetic cystopathy is a chronic complication of diabetes with a classic triad of symptoms: decreased bladder sensation, increased bladder capacity, and impaired detrusor contractility. This article discusses age- and diabetes-related changes that affect lower urinary tract function. The article also reviews bladder function in the older adult diabetic, explores bladder dysfunction prevention, and suggests management strategies for diabetic cystopathy. Little research has been published to date to guide practice in this area, and opportunities exist for nursing research to fill the gap in knowledge.
 ...
PMID:Diabetes-associated bladder dysfunction in the older adult (CE). 1281 25

Diabetic cystopathy is one of the common complications of diabetes and current therapy is limited. In the present study, the effects of gene therapy, using replication-defective herpes simplex virus type 1 (HSV-1) vectors to deliver and express the nerve growth factor (NGF) gene (HSV-NGF) on tissue NGF levels and bladder function, were evaluated in streptozotocin (STZ)-induced diabetic rats. Diabetic rats exhibited a significant decrease in NGF levels in the bladder and lumbosacral dorsal root ganglia (DRG) detected by enzyme-linked immunosorbent assay and displayed marked bladder dysfunction 12 weeks after STZ injection. In contrast, rats with bladder wall injection of the NGF expression vector 8 weeks after STZ treatment exhibited a significant increase of NGF levels in the bladder and L6 DRG 4 weeks after HSV-NGF injection. Along with the restoration of tissue NGF expression, in metabolic cage studies and cystometry, HSV-NGF-injected rats also showed significantly reduced bladder capacity and postvoid residual volume than diabetic rats injected with the control vector (HSV-lacZ), indicating that voiding function was improved after HSV vector-mediated NGF gene delivery. Thus, HSV vector-mediated NGF gene therapy may prove useful to restore decreased NGF expression in the bladder and bladder afferent pathways, thereby improving hypoactive bladder function in diabetes.
Diabetes 2004 Oct
PMID:Gene therapy using replication-defective herpes simplex virus vectors expressing nerve growth factor in a rat model of diabetic cystopathy. 1544 8

We investigated the effect of thiamine (B1) treatment on bladder dysfunction in streptozotocin (STZ)-induced diabetic rats. A total of 40 rats were randomly divided into four groups: a control group, a group given thiamine only, a diabetic group and a diabetic group given thiamine therapy. Diabetes was induced in the rats by 65 mg/kg STZ via an intraperitoneal injection. Thiamine was given 50 mg/kg/day. Diabetic cystopathy was confirmed on cystometry 8 weeks later in diabetic groups. Rats' body and bladder weights were measured. Contractile response to carbachol and potassium chloride (KCl) of detrusor strips in all groups was studied in vitro. The body weights were significantly decreased (p<0.01), the bladder weights were significantly increased (p<0.01), and the cystometric bladder capacity and the residual urine volumes were significantly increased (p<0.001, p<0.01 respectively) in STZ-induced diabetic groups compared to the control group and the group given thiamine only. Contractile responses increased in the diabetic group in high carbachol and KCl concentrations (p<0.01, p<0.01, respectively). On the other hand, there were no differences in the other groups. These data suggest that high-dose thiamine (B(1)) treatment may be beneficial in delaying the progression of diabetic cystopathy in this experimental animal model.
 ...
PMID:Protective effect of high-dose thiamine (B1) on rat detrusor contractility in streptozotocin-induced diabetes mellitus. 1721 59

Diabetic cystopathy is a common complication of diabetes mellitus, which is assessable by urodynamic study. The purpose of this study was to determine the association between urodynamic findings and microvascular complications (neuropathy, retinopathy, nephropathy) in patients with long-term type 2 diabetes but without voiding symptoms. A total of 66 consecutive patients (26 males and 40 females, age 57.00+/-9.50 years, diabetes duration 14.44+/-6.78 years) with documented type 2 diabetes, low scores at the International Prostate Symptom Score (IPSS) and no subjective complaint of voiding problems were included in the study. Seven urodynamic parameters were considered: detrusor activity, bladder capacity, bladder compliance, first sensation of filling, flow rate, bladder outlet status and post-voiding residue. The following independent associations were found: between female sex and increased bladder capacity (p=0.004), between male sex and both decreased bladder compliance (p=0.023) and bladder outlet obstruction (p=0.001), between old age and both low flow rate (p=0.022) and outlet obstruction (p=0.047), between detrusor instability and shorter duration of diabetes (p=0.044) and between peripheral somatic neuropathy and low flow rate (OR=5.208; 95%CI=1.277-21.277). The Spearman's correlation coefficient for the latter association was 0.356 (p=0.005) and remained significant even after controlling for age, sex, HbA1c and diabetes duration (rho=0.310; p=0.019). In conclusion, searching for microvascular complications might be used to screen for some components of diabetic cystopathy in its asymptomatic phase.
Diabetes Res Clin Pract 2007 Oct
PMID:The association between urodynamic findings and microvascular complications in patients with long-term type 2 diabetes but without voiding symptoms. 1736 56

Diabetes mellitus (DM) has reached epidemic proportions world wide. Many chronic complications of DM, including neuropathy, retinopathy and nephropathy, have been well studied and although urologic complications have been recognized since 1935, little is known about DM as a pathophysiological risk factor for development of lower urinary tract symptoms (LUTS) in women. Diabetic nephropathy, a life-threatening condition, has received considerable attention in the last few years. Diabetic cystopathy, on the other hand, has received far less attention despite having a significant impact on quality of life, and with significant individual health risks. Initial studies suggested that long standing DM causes paralysis of the detrusor muscle leading to voiding difficulties and this has been the received wisdom regarding diabetic cystopathy for many years. In this review, we discuss what is currently known about lower urinary tract function and urinary incontinence in diabetic females, with a critical analysis of the available evidence and suggest areas for future research.
 ...
PMID:Diabetes mellitus and female lower urinary tract symptoms: a review. 1804 70

Diabetic cystopathy is a well-recognized complication of diabetes mellitus, which usually develops in middle-aged or elderly patients with long-standing and poorly controlled disease. It may have broad spectrum clinical presentations. Patients may be asymptomatic, or have a wide variety of voiding complaints from overactive bladder and urge incontinence to decreased bladder sensation and overflow incontinence. This review focuses on pathophysiological mechanisms responsible for urologic complications of diabetes and emphasizing on recent developments in our understanding of this condition. We also tried to shed some light on therapeutic modalities like behavioral, pharmacological, and surgical approaches.
 ...
PMID:Bladder dysfunction in diabetes mellitus. 2183 75


1 2 Next >>