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A nutrition rich in fibre has a preventive effect against constipation, colon diverticulosis, carcinoma of the large bowel and stomach, type 2-diabetes, metabolic syndrome and cardiovascular disease. In case of constipation, diverticulosis and diabetes this effect solely depends on dietary fibre. Regarding carcinomas and cardiovascular diseases, so far unknown factors integrated in or associated with fibre-rich food may also contribute to the preventive effect. Therapy with dietary fibre is indicated for constipation, colon diverticulosis, diarrhea, diabetes, and hypercholesterinemia. The individual dietary fibres differ substance-specifically. Food-integrated dietary fibre such as whole-grain bread, vegetables and fruit have their place in prevention. Dietary fibre preparations such as wheat bran, flax seed or sugar-beet fibre are useful in the treatment of constipation, colon diverticulosis and adiposity. Oat bran is preferentially used in hypercholesterinemia. Purified dietary fibres such as cellulose, guar, psyllium, and beta-glucan have an anti-diabetic, all viscous fibres an anti-lipaemic effect. The therapeutic dosages of dietary fibre preparations are 20-40 g/day and of purified fibres substances 10-20 g/day respectively.
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PMID:[Dietary fibre: more than a matter of dietetics. II. Preventative and therapeutic uses]. 1547 Nov 77

Physical activity is crucial for maintaining normal structure and function of metabolic processes and body organs, such as the heart and muscles. Lack of regular activity leads to the deterioration of these organs, thereby increasing levels of morbidity and mortality. Physical activity is associated with lower incidence of total mortality and mortality from heart diseases. It also inhibits high blood pressure, diabetes mellitus, colon cancer and probably breast cancer, osteoporosis, mental depression, and improves quality of life. While the favorable outcomes are usually related to activity level in a dose-response pattern, the greatest benefit is observed in the transition from sedentary to moderately active lifestyle. Despite possible direct and indirect adverse effects of physical activity, the benefits markedly outweigh the risk. In order to benefit from physical activity, people should perform activities that involve large muscle mass, at moderate intensity, during most of the week, or at least 3 days/week, for about 30 minutes a day. It is desirable to add strength and flexibility exercises. The need for medical screening prior to initiation of activity is questionable, and there are no solid recommendations. In the opinion of the authors, at all ages people should be aware of whether they possess one or more risk factors for cardiovascular disease. Young healthy people free of risk factors may start activity, gradually, without special preparations or screening. However, men and women above the age of 45 or 50 years, respectively, or younger, if a risk factor is present, should consult their family physician or a specialist in order to perform relevant screening and obtain instructions on the desired nature of recommended physical activity, its length and intensity.
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PMID:[By the sweat of your brow shall you eat bread: a blessing or a curse?]. 1571 22

Atraumatic infections due to Clostridium septicum are known to be associated with immunosuppression or even malignancy. In this case report, we present a patient with severe Clostridium septicum infection related to advanced colon cancer that had not previously been diagnosed. The case demonstrates the strong association between Clostridium septicum infections and malignancy, particularly in the presence of other predisposing diseases such as diabetes mellitus. It strongly suggests excluding malignant neoplasms, especially of the gastrointestinal tract, when severe Clostridium septicum infections occur. Moreover, if patients with known colorectal or other malignancy develop septicaemia or spontaneous gas gangrene, clinicians should be aware of Clostridium septicum as one of the main causative agents, as early diagnosis and aggressive treatment are important to improve prognosis.
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PMID:[Spontaneous gas gangrene in a diabetic patient with Clostridium septicum]. 1602 94

Overweight and obesity increase the risk of developing several cancers. Once cancer develops, individuals may be at increased risk of recurrence and poorer survival if they are overweight or obese. A statistically significant association between overweight or obesity and breast cancer recurrence or survival has been observed in the majority of population-based case series; however, adiposity has been shown to have less of an effect on prognosis in the clinical trial setting. Weight gain after breast cancer diagnosis may also be associated with decreased prognosis. New evidence suggests that overweight/obesity vs normal weight may increase the risk of poor prognosis among resected colon cancer patients and the risk of chemical recurrence inprostate cancer patients. Furthermore, obese cancer patients are at increased risk for developing problems following surgery, including wound complication, lymphedema, second cancers, and the chronic diseases affecting obese individuals without cancer such as cardiovascular disease and diabetes. Mechanisms proposed to explain the association between obesity and reduced prognosis include adipose tissue-induced increased concentrations of estrogens and testosterone, insulin, bioavailable insulin-like growth factors, leptin, and cytokines. Additional proposed mechanisms include reduced immune functioning, chemotherapy dosing, and differences in diet and physical activity in obese and nonobese patients. There have been no randomized clinical trials testing the effect of weight loss on recurrence or survival in overweight or obese cancer patients, however. In the absence of clinical trial data, normal weight, overweight, and obese patients should be advised to avoid weight gain through the cancer treatment process. In addition, weight loss is probably safe, and perhaps helpful, for overweight and obese cancer survivors who are otherwise healthy.
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PMID:Obesity and cancer: the risks, science, and potential management strategies. 1605 36

The IGFs are ubiquitous and have pleoitropic effects. They are critical for normal growth and development, and for normal functioning of adult tissues. A liver-specific gene-deletion knockout of the IGF-I gene resulted in a mouse model with reduced circulating IGF-I levels, that led to insulin resistance due to the secondary elevation of circulating GH levels. The reduction in circulating IGF-I levels was also associated with a reduction in cancer growth and metastases in three cancer models, one for colon cancer and two for breast cancer. A second mouse model, using the transgenic approach, inhibited the IGF-I and insulin receptor function in skeletal muscle, and resulted in severe insulin resistance in muscle followed by insulin resistance in fat and liver and, eventually, beta-cell dysfunction and development of Type 2 diabetes. This progression from insulin resistance to Type 2 diabetes was most likely due to lipotoxicity with elevated serum and tissue triglyceride levels. Evidence supporting the hypothesis came from the use of fibrates and leptin injections, each of which enhanced fatty acid (FA) oxidation in liver and muscle and was associated with a reversal of the insulin resistance and diabetes.
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PMID:Studies involving the GH-IGF axis: Lessons from IGF-I and IGF-I receptor gene targeting mouse models. 1611 70

Regular physical activity improves quality of life and reduces risk for coronary heart disease, colon cancer, hypertension, diabetes, and overall mortality. Physical activity also has been associated with reduced symptoms of depression and greater independence. A sedentary lifestyle is associated with obesity. However, despite the health benefits of physical activity, 23.1% of adults in the United States report they do not engage in any leisure-time physical activity. Neighborhood environment (e.g., sidewalks and street lighting), perceived trustworthiness of neighbors, and perceptions of neighborhood safety all have been associated with levels of physical activity. During 2004, to assess the association between these factors and leisure-time physical inactivity in eastern Travis County, Texas, the local health department collected and analyzed data by using the methodology of the Behavioral Risk Factor Surveillance System (BRFSS). This report describes the results of that analysis, which indicated that persons who perceived their neighborhoods as less than extremely safe were more than twice as likely to have no leisure-time physical activity, and those who perceived their neighborhoods as not at all safe were nearly three times as likely to have no leisure-time physical activity. Public health agencies promoting physical activity in neighborhoods should consider how residents perceive their safety and design programs that specifically address those safety concerns.
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PMID:Perceptions of neighborhood characteristics and leisure-time physical inactivity--Austin/Travis County, Texas, 2004. 1617 84

Walking for transportation is part of an active lifestyle that is associated with decreased risks for heart disease, diabetes, hypertension, and colon cancer and an increased sense of well being. However, the percentage of trips made by walking has declined over time among both children and adults. One of the objectives of Healthy People 2010 (no. 22-14b) is to increase among children and adolescents the proportion of trips to school made by walking from 31% to 50%. In 1969, approximately half of all schoolchildren walked or bicycled to or from school, and 87% of those living within 1 mile of school walked or bicycled. Today, fewer than 15% of children and adolescents use active modes of transportation. This report examines data from the 2004 ConsumerStyles Survey and a follow-up recontact survey to describe what parents report as barriers to their children aged 5-18 years walking to or from school. Distance to school was the most commonly reported barrier, followed by traffic-related danger. Comprehensive initiatives that include behavioral, environmental, and policy strategies are needed to address these barriers to increase the percentage of children who walk to school.
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PMID:Barriers to children walking to or from school--United States, 2004. 1619 92

Obesity is a risk factor for many diseases. Thirty per cent of Americans are viewed as super obese; therefore, we need to find a solution. We already know about the diseases associated with obesity such as high blood pressure, diabetes, sleep apnoea, etc. Lately, there has been an increased interest in understanding if cancer is related to obesity. In this paper, we review the incidence of colon cancer and obesity. Insulin is the best established biochemical mediator between obesity and colon cancer. Hyperinsulinaemia, such as occurs in type II diabetes, is important in the pathogenesis of colon cancer. All adipose tissue is not equal. Visceral abdominal fat has been identified as the essential fat depot for pathogenetic theories that relate obesity and colon cancer. The genders differ as regards to how the relationship between obesity and colon cancer has been evaluated. Obesity imposes a greater risk of colon cancer for men of all ages and for premenopausal women than it does for postmenopausal women. Regular exercise reduces the risk of developing colon cancer and the risk of death from colon cancer should it develop. We believe that a combination of waist circumference (WC) and body mass index (BMI) measurements is recommended to assess the obesity related risk of developing colon cancer. Radiographic assessments of visceral abdominal fat may eventually prove to be the best means of assessing a patient's obesity related risk of developing colon cancer. Although WC is better established as a measure of obesity than BMI, the evidence for colon cancer risk is not secure on this point; combining BMI and WC measurements would appear, at present, to be the wisest approach for colon cancer risk assessment. Doctors who wish to decrease their patients' risk of dying of colon cancer should advise weight loss and exercise. Conversely, physicians and public health authorities should consider both exercise and obesity when designing colon cancer screening protocols. Morphometric cut offs should be adjusted, if possible, for age, sex, ethnicity, and height.
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PMID:Influence of obesity on the risk of developing colon cancer. 1756 47

Polyphenols in fruits, soybean, vegetables, herbs, roots and leaves act as bioactive components related with prevention of cancer, heart diseases and diabetes. We investigated the apoptotic effects of polyphenols from red wine on human colon cancer cells SNU-C4 using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, 4,6-diamidino-2-phenylindole (DAPI) staining, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcription-polymerase chain reaction (RT-PCR) expressions of Bcl-2, Bax and Caspase-3 genes, and Caspase-3 enzyme activity. Polyphenols (100 microg/ml) increased the apoptosis of SNU-C4 cells with apparent apoptotic characteristics including morphological changes of chromatin condensation and apoptotic body formation from DAPI staining and TUNEL assay. Compared with untreated control group, polyphenols (100 microg/ml) reduced the expression of Bcl-2 whereas those of Bax and Caspase-3 were increased. The Caspase-3 activity in the polyphenols treated group was significantly increased compared to those in control group (P<0.05). These results suggest that polyphenols have a strong potential for development as an anti-colon cancer agent.
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PMID:Apoptotic effect of red wine polyphenols on human colon cancer SNU-C4 cells. 1624 19

The purpose of the study is to explore cancer screening predictors and practices among Lumbee Indians in eastern North Carolina. Interviewers from the community conducted phone interviews with 333 men and 456 women aged 40 and older randomly selected from the Lumbee Tribal roll as part of the Lumbee Diabetes and Health Survey. The survey has sections on demographic information and health conditions, family history of chronic conditions, and health behaviors. This paper reports on cancer screening behaviors. Rates of ever being screened for breast, cervical, prostate and colon cancer were relatively high compared with overall national rates. Predictors included younger age, better health, more education, and lifestyle factors such as engaging in regular physical activity and not smoking. Future research should focus on developing culturally appropriate campaigns to increase the frequency of cancer screening to conform to guidelines, and educational programs and interventions to reach Lumbee Indians most at risk for not being screened.
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PMID:Cancer screening among Native Americans in eastern North Carolina. 1631 89


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