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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Reactive perforating collagenosis is a disease whose pathogenesis is still not fully understood. Histological findings are degenerated collagen bundles which are arranged in vertical direction penetrating the epidermis into a dome-shaped crater. Usually diabetes mellitus and renal failure can be found among patients with reactive perforating collagenosis. To date, there have been five cases described where the eruption of reactive perforating collagenosis followed herpes zoster infection. This could be a form of Wolf's isotopic response, a term that is used for dermatoses which arise after the healing of a preexisting dermatosis. We report the sixth case of a herpes zoster-associated reactive perforating collagenosis and discuss the current literature.
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PMID:[Acquired reactive perforating collagenosis following herpes zoster as isotopic response?]. 2173 60

Reactive perforating collagenosis (RPC) is a rare disease belonging to the spectrum of primary perforating dermatoses. It manifests clinically with brown-erythematous papules with a central plug that develop after minor skin trauma, and it is characterized histologically by epidermal perforation and transepidermal elimination of altered dermal collagen. Familial and acquired forms have been described, the latter usually associated with systemic diseases, among which diabetes mellitus and renal failure are the most common. A new case of RPC is presented here, along with an updated brief literature review on this unusual dermatosis.
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PMID:Reactive Perforating Collagenosis. 3057 6

Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. However, it has also been described as a paraneoplastic syndrome. The authors present the case of a 65-year-old diabetic patient in which a myeloproliferative neoplasm was suspected.
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PMID:Case for diagnosis. Hyperpigmented and excoriated papules and nodules in a diabetic patient. 3303 8


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