Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Occupational mortality among Hong Kong males aged 15 and above were examined for the period 1979-1983, using routine death registration and census data. Age-standardized mortality ratios (SMR) and relative SMR (RSMR) were calculated for each two-digit occupational group and elevated mortality from all and various causes were highlighted. Mortality from ischaemic heart disease was strikingly associated with professional and sales-managerial occupations whereas colorectal cancers were associated with predominantly clerical and sales workers. Mortality from cancer of the buccal cavity and pharynx was elevated in fishermen as well as in farmers, food, drink and tobacco workers, mechanical fitters, and others. Excesses of liver cancer were found in doctors, fishermen and construction workers. Lung cancer deaths were particularly excessive among fishermen, plumbers and welders, construction workers and transport equipment operators. Fishermen were at high risk of death from cancers of the buccal cavity and pharynx, stomach, liver and lung, cerebrovascular diseases and cirrhosis. Miners and quarrymen experienced high mortality from pulmonary tuberculosis and chronic obstructive airways disease whereas construction workers also experienced high mortality from pulmonary tuberculosis as well as cancers of the liver, lung and bladder and non-Hodgkin's lymphomas. Transport workers were at high risk of dying from cancers of the stomach and lung, cerebrovascular diseases and diabetes mellitus. These and other associations were generally in line with those found from other similar surveys or detailed studies. The limitations of such studies are many and discussed in the context of Hong Kong.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Occupational mortality in Hong Kong, 1979-1983. 326 Feb 22

In order to test the hypothesis that Roman Catholic priests are at low risk for prostatic cancer because of their celibacy, a cohort of 10,026 men who were active or retired diocesan (parish) Roman Catholic priests in the United States on January 1, 1949 were followed until death, leaving the priesthood, or January 1, 1978. The overall standardized mortality ratio (SMR) was 103 and the SMR for cancer of the prostate was 81. Other interesting findings include increased SMRs for cancer of the larynx (147), cirrhosis of the liver (147), and diabetes (182) and decreased SMRs for lung cancer (59), emphysema (26), and suicide (13).
 ...
PMID:Retrospective cohort mortality study of Roman Catholic priests. 340 88

It has been established that the pyrogallol autoxidation method for the estimation of the activity of superoxide dismutase (SOD) (EC 1.15.1.1) is superior in precision and sensitivity to a superoxide-generating method (NADH/phenazine methosulfate linked to nitroblue tetrazolium reduction). Reference intervals were established in an urban population in the Far East for SOD activity in erythrocytes using the pyrogallol method, and for glutathione peroxidase (GSH-Px) (EC 1.11.1.9) activity in erythrocytes using a standard glutathione reductase-linked method. On this basis, erythrocyte SOD activities were significantly (P less than 0.05) depressed in cases of visceral cancer, acute myocardial infarct, congestive heart failure, respiratory failure, chronic renal failure, and diabetes mellitus, but within the reference interval in cases of lung cancer and asthma. Erythrocyte GSH-Px activity was significantly (P less than 0.05) depressed in cases of diabetes mellitus and chronic renal failure but elevated in respiratory failure and asthma. GSH-Px and SOD activities were well correlated in patients but not in the reference population.
 ...
PMID:Superoxide dismutase and glutathione peroxidase activities in erythrocytes as indices of oxygen loading in disease: a survey of one hundred cases. 366

Mortalities from selected causes from 1973 to 1982 among Koreans, Chinese, and Americans residing in Japan were compared with those of Japanese. In the Korean population, besides the well-documented excess in mortalities from liver cancer, lung cancer, liver cirrhosis and male tuberculosis, a rather prominent elevation was observed for mortalities from female tuberculosis and diabetes mellitus in both sexes. Distinctive features in the Chinese population were increased mortalities from liver cancer and female lung cancer and lowered mortality from stomach cancer, and these findings are consistent with the observations among Chinese in other areas. Mortalities from diabetes mellitus and liver cirrhosis was moderately increased in this population as well. Americans in Japan by and large showed a mortality pattern similar to that in the US although mortality from stroke among female Americans was rather elevated during the period 1973-1977. Epidemiological studies on Koreans and Chinese in Japan with reference to their lifestyle are strongly required.
 ...
PMID:Cause-specific mortality among Koreans, Chinese and Americans in Japan, 1973-1982. 366 40

A proportionate mortality ratio (PMR) study was undertaken of 7,121 members and retirees of the United Association of Plumbers and Pipefitters in California who died in 1960-79. The PMR for all malignant neoplasms was 1.24, with a major contribution from lung cancers (PMR = 1.41). Lung cancer PMRs were consistently elevated, through the 20-year study period, across the pipe trades and within different birth cohorts. Sixteen mesothelioma deaths occurred, suggesting asbestos as a risk factor. PMRs for malignancies of the stomach, kidney, brain, and lymphopoietic system were also elevated, especially among plumbers. Chronic rheumatic heart disease, emphysema, liver cirrhosis, and all external causes of death were the major non-cancer causes with significantly elevated PMRs. There were significant deficits in diabetes mellitus, all pneumonia, chronic nephritis, and vascular lesions of the central nervous system (CNS). PMRs for successive birth cohorts among all study subjects revealed decreasing emphysema risk, suggesting previous reduction of a risk factor for this disease. Among plumbers, PMRs for death due to several non-respiratory malignancies showed an increasing trend with recency of birth cohort.
 ...
PMID:Patterns of mortality among plumbers and pipefitters. 374 68

To identify risk factors for developing pneumococcal infections, we carried out a case-controlled study on a retrospectively constituted cohort of 3074 clinic patients in a presumed high-risk population. Culture-proved pneumococcal infections were identified in 63 men over a period of 5.5 years, yielding an estimated incidence of 6.3 cases per 1000 person-years. By comparing these patients with 130 uninfected control patients, the relative risk of pneumococcal infections related to various exposures was calculated by logistic regression analysis. Statistically significant independent risk factors (and their relative risks) were as follows: dementia (5.82), seizure disorders (4.38), current cigarette smoking (4.00), congestive heart failure (3.83), cerebrovascular disease (3.82), institutionalization (3.13), and chronic obstructive pulmonary disease (2.38). Risk was increased with age and previous hospitalizations, and, to a nonsignificant degree, by hotel residence (3.93), lung cancer (2.24), previous smoking (2.14), corticosteroid use (1.81), and alcoholism (1.35); but not by diabetes mellitus (0.99), nonlung malignancies (0.93), nonwhite race (0.89), or ischemic heart disease (0.58).
 ...
PMID:Risk factors for acquiring pneumococcal infections. 377 47

In the years 1980-1983 M. xenopi was isolated from the sputum of 37 persons, 30 of them living in the agglomeration of the regional town in the region of Northern Bohemia with 1,175,000 inhabitants. Only 7 of these 30 had manifestation of pulmonary disease. M. xenopi was found repeatedly in the sputum in 5 patients out of 7 affected and in 2 out of 23 persons who showed no signs of a disease. The prevalence was in males between the age of 52-67 years. All of them suffered from other diseases, as chronic bronchitis, TB healed after lobectomy, lung cancer, fibrotic lung lesions, diabetes mellitus, gastric ulcer healed by resection, chronic alcoholism. Investigations were made for detection of the source of infection. Bacteriological examinations of cold and warm tap water in flats of 9 persons with M. xenopi in their sputa were carried out, as well as cold and warm tap water from flats of 2 healthy persons. M. xenopi was found in tap water of 5 persons with M. xenopi in their sputum and in one of the two healthy persons. In the water of one household we found M. kansasii. We came to the conclusion, that transmission carried out in susceptible persons is most probably due to aerosol during washing and showering with water, containing these mycobacteria.
 ...
PMID:Water-borne Mycobacterium xenopi--a possible cause of pulmonary mycobacteriosis in man. 380 13

Cause-specific mortality was surveyed among 19,608 male employees with 1 or more years of service between 1940 and 1980 at the Texas Operations of Dow Chemical U.S.A. Vital status was ascertained through 1980 for 97.3% of the cohort members, and death certificates were obtained for 96.4% of the 3,444 decedents. Mortality risks were found to vary, depending upon which of 3 population groups (United States, Texas, and local counties) was used for comparison, although significantly fewer than expected deaths from all causes was a common finding due to significant deficits in diabetes, diseases of the circulatory system, and cirrhosis of the liver. Significantly more deaths were from ill-defined conditions and cancers of unspecified sites. Lung cancer was significantly elevated in comparisons with the incidences in the United States and Texas, but not in comparison with those in the local counties. The influence of age at hire, period of hire, duration of employment, interval since entry into cohort, employment status, and two measures of social class--educational level and job category--were explored with the use of the Mantel-Haenszel method as adapted for a cohort study. Findings from these analyses are discussed in relation to the observations of other investigators and in the context of the possible impact of these findings on future studies of this work force.
 ...
PMID:Mortality among a large cohort of chemical manufacturing employees. 386 87

Ceftizoxime (CZX), a parenteral cephalosporin derivative belonging to the so-called third generation cephalosporin is reported to have a broad antibacterial activity, particularly against Gram-negative aerobic bacilli and some anaerobes, such as Bacteroides fragilis and a good stability to beta-lactamases. Clinical study was performed on a total of 20 cases, 9 females (1 case had urinary tract infection 3 times) and 11 males, aged from 27 to 82 years. All patients had the underlying diseases. They were bronchial asthma in 3 cases, influenza in 1, chronic pulmonary emphysema in 1, pulmonary fibrosis in 1, chronic bronchitis with strongyloidiasis in 1, lung cancer in 3, esophagus cancer in 2, stomach cancer in 1, hepatoma with urolithiasis in 1, liver cirrhosis with diabetes mellitus in 1, alcoholism with strongyloidiasis in 1, cholelithiasis in 1 and congestive heart failure in 1, respectively. Clinical diagnoses for infections were 2-acute bronchitis, 2-exacerbation of chronic bronchitis, 2-broncho-pneumonia, 2-pneumonia including one suspected case, 1-obstructive pneumonia, 2-secondary pulmonary infection, 1-pulmonary infection, 3-urinary tract infection (UTI), 1-UTI with sepsis, 1-sepsis, 1-sepsis with purulent meningitis, 1-biliary tract infection and 1-infected bronchoesophageal fistula. CZX was given by intravenous drip infusion, at a dose of 1 to 2 g, twice daily for 3 to 15 days. Because of severity in infections and underlying diseases, some cases were treated either steroid, gamma-globulin preparations or other antibiotics in combination with CZX. Twelve out of 15 cases assessed clinically responded satisfactorily to the treatment and efficacy rate was 80.0%.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Effectiveness of ceftizoxime on various infections in patients with underlying diseases]. 609 Jul 23

Causes of deaths in immigrants to England and Wales from the Indian subcontinent were assessed by ethnic subgroup. Observed and expected deaths for 1975-7 were aggregated to calculate proportional mortality ratios. Observed mortality due to infective and parasitic diseases, endocrine diseases (notably diabetes), diseases of the circulatory system (notably ischaemic heart disease and cerebrovascular disease, in males), and diseases of the digestive system (notably cirrhosis of the liver) exceeded expected mortality. Fewer than expected deaths were due to malignant neoplasms (notably lung cancer and chronic bronchitis); proportional mortality ratios for cancer were lower for Hindu groups than for Moslems and were lowest for Punjabis. Mortality due to ischaemic heart disease, high in all groups, was highest in Moslems. Significantly more Punjabi males died from cerebrovascular disease and cirrhosis of the liver. Diabetes was commonest among Gujaratis. The variation seen in the patterns of mortality in the different ethnic groups indicates the need for further epidemiological and health service research centred on these communities.
 ...
PMID:Patterns of mortality among migrants to England and Wales from the Indian subcontinent. 643 78


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>