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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The cornea was thought to be not for a long time saved from the havoc of the diabetes. Last time a series of authors talk about a diabetic keratopathy. For the beginning the cornea endothelium was involved (changes of density and form of the cells) and last time the cornea epithelium was involved, some authors making a correlation between the diabetic neuropathy and keratopathy that consider a special entity, the diabetic keratopathy. We kept under the observation a group of diabetic patients who were hospitalized at our clinic of ambulatory examined for various complications of diabetes, in order to discover if it exist a relationship between the two affection, neuropathy and keratopathy. The number of the diabetic neuropathies is more less (13.3%) than that of the diabetic retinopathies or nephropathies. The keratopathies were observed for 6.6% (much inferior to other statistics). Half of the cases of keratopathies have presented either symptom of neuropathies or any other neurological charge; though for the first time it could be done the relationship between the two affections, the examination of the patients often pleads for coincidences; it's why we wonder if it really exist a diabetic keratopathy or a keratopathy at the diabetic patient.
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PMID:[Does diabetic keratitis exist?]. 152 43

Five eyes of three patients developed generalized corneal decompensation after undergoing argon laser iridectomy for angle closure glaucoma. Factors possibly associated with corneal decompensation include episodes of angle closure glaucoma with pressure elevations and inflammation, corneal guttate, diabetes, and the need for multiple treatments requiring a high-laser energy. It is important for ophthalmologists to inform their patients of the rare risk of developing bullous keratopathy after argon laser iridectomy and to consider obtaining prelaser specular microscopy to document the corneal status in high-risk patients.
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PMID:Corneal decompensation after argon laser iridectomy. 305 53

In diabetic cataracts aldose reductase initiates the cataractous process by converting glucose to sorbitol. The ensuing osmotic change, caused by sorbitol accumulation, adversely affects the lens permeability barrier so that the distribution within the lens of electrolytes, amino acids, and myo-inositol becomes grossly altered. These changes affect lens viability resulting in opacification. That aldose reductase triggers the process is shown by the fact that several structurally unrelated aldose reductase inhibitors prevent cataracts from occurring. Aldose reductase is also implicated in diabetic retinopathy and keratopathy. Aldose reductase functions in the retinal capillary pericytes, the cells first affected in microvascular abnormalities in diabetes. Additionally, retinal capillary basement membrane thickening can be prevented by aldose reductase inhibitors. Clinical trials are underway to determine the efficacy and safety of aldose reductase inhibitors in treatment of diabetic retinopathy.
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PMID:Aldose reductase in the diabetic eye. XLIII Edward Jackson memorial lecture. 309 7

We studied HLA-A, -B, -C, and -DR antigens in 45 patients (from among 34 families), aged 10.2-60 yr, with polyglandular autoimmune disease type I (APG I) and in other family members. HLA-A28 was more frequent in the patients (25%) than in unaffected siblings (16%; P less than 0.05) or in normal Finnish subjects (8.8%; P less than 0.005, corrected P less than 0.2). Compared with the normal subjects, HLA-A28 was more frequent in the patients with hypoparathyroidism (31%; P less than 0.001, corrected P less than 0.04), adrenocortical failure (27%; P less than 0.01), insulin-dependent diabetes mellitus (IDDM; 66%; P less than 0.01), keratopathy (53%; P less than 0.001, corrected P less than 0.04), and alopecia (40%; P less than 0.001, corrected P less than 0.04), but not in the patients with ovarian failure (9%; P = NS). HLA-A28 was more frequent in the patients with hypoparathyroidism (31%) than in APG I patients without it (13%; P less than 0.005, corrected P less than 0.2). It was also more frequent in the patients with IDDM (66%) than in those without it (21%; P less than 0.05). HLA-A3 was more frequent in the patients with ovarian failure (82%) than in APG I patients with normal ovarian function (22%; P less than 0.025) and in normal subjects (45.5%; P less than 0.05). HLA-A9 was less frequent in the patients with ovarian failure (0%) than in those with normal ovarian function (55%; P less than 0.005, corrected P less than 0.2), and it was less frequent (P less than 0.025) in the patients with adrenocortical failure than in those with normal adrenal function. No association was found with any single DR antigen, but of 4 DR-typed IDDM patients, 3 were DR3 or DR4 positive (P = NS). The occurrence of adrenocortical failure, but not hypoparathyroidism, was familial and associated with HLA haploidentity among sets of affected siblings.
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PMID:The expression of autoimmune polyglandular disease type I appears associated with several HLA-A antigens but not with HLA-DR. 316 97

Extracapsular extraction with anterior-chamber lens implantation is a method which has a place in cataract surgery. We discuss 60 cases of cataract operated on by this method and its advantages. We had good results in cases without glaucoma, keratopathy, or diabetes mellitus, and depending on the ease with which a posterior capsulotomy was done, where this was imperative, without the risks of the YAG laser capsulotomy.
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PMID:Extracapsular extraction and anterior-chamber flexible lens implantation. 321 19

Diabetes mellitus, which affects millions of people all over the world, produces significant ocular morbidity. Corneal complications such as tear film dysfunction, elevated glucose in tears, different forms of epitheliopathy, neurotrophic ulcers, corneal edema, wrinkles in Descemet's membrane and decrease in corneal sensitivity have been reported. While a few reports described altered epithelial morphology as the possible basis for epithelial disease, all other clinical phenomena have been unexplained thus far. In this first-ever multifaceted approach to study the pathogenesis of diabetic keratopathy, striking abnormalities were observed in corneal nerves, corneal epithelium and corneal endothelium of diabetics. We have clearly demonstrated the existence of neuropathy in diabetic cornea, both in an animal model and in the humans, -- the first demonstration of such an abnormality. Our in vivo specular microscopic observations on epithelium confirmed in vitro observations in our study as well as of others while the analysis of endothelium provided the basis for the problems noticed in the diabetic cornea following intraocular surgical procedures. Our observations should help the clinician in the understanding of diabetic keratopathy and in developing better prophylactic and therapeutic strategy against some recalcitrant forms of corneal disease in this group of individuals.
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PMID:Dr. P. Siva Reddy Oration. Diabetic keratopathy. 350 67

In a study of 102 patients (64 women and 38 men; 63 whites and 39 nonwhites; 77 with adult-onset disease and 25 with juvenile-onset disease), the data, after being adjusted for age, showed that diabetic peripheral neuropathy was associated with diabetic keratopathy. The strongest predictor of both keratopathy and corneal fluorescein staining was vibration perception threshold in the toes (P less than .01); the severity of keratopathy was directly related to the degree of diminution of peripheral sensation. Other predictors of keratopathy were reduced tear break-up time (P less than .03), the type of diabetes (P less than .01), and metabolic status, shown by fasting C-peptide levels (P less than .01). No significant relationships were found between keratopathy and tear glucose levels, endothelial cell densities, corneal thickness, or duration of disease.
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PMID:Diabetic keratopathy as a manifestation of peripheral neuropathy. 631 Oct 17

Corneal epithelial lesions can be found in approximately one-half of asymptomatic patients with diabetes mellitus. These lesions are transient and clinically resemble the keratopathy seen in staphylococcal keratoconjunctivitis. Staphylococcal organisms, however, can be isolated in equal percentages from diabetic patients without keratopathy. Diabetic peripheral neuropathy was found to be related to the presence of diabetic keratopathy after adjusting for age with analysis of covariance. The strongest predictor of both keratopathy and corneal fluorescein staining was vibration perception threshold in the toes (P less than 0.01); and the severity of keratopathy was directly related to the degree of diminution of peripheral sensation. Other predictors of keratopathy were: reduced tear breakup time (P less than 0.03), type of diabetes (P less than 0.01), and metabolic status as indicated by c-peptide fasting (P less than 0.01). No significant relationships were found between the presence of keratopathy and tear glucose levels, endothelial cell densities, corneal thickness measurements, the presence of S epidermidis, or with duration of disease. It is our conclusion that asymptomatic epithelial lesions in the nontraumatized diabetic cornea can occur as a manifestation of generalized polyneuropathy and probably represent a specific form of corneal neuropathy.
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PMID:Diabetic corneal neuropathy. 667 64

This case study focuses on keratopathy and chorioretinopathy resulting congenital syphilis. The patient is a 51-year-old man who had diabetes mellitus for eleven years. Furthermore he had interstitial keratitis due to syphilis. Both fundi showed chorioretinal atrophy. The fundus findings were similar to those of retinitis pigmentosa. We examined the visual field, ERG and dark adaptation. The serological test for syphilis was positive. A diagnosis of congenital syphilis with keratopathy and chorioretinopathy was made.
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PMID:[A case of syphilitic keratitis and retinopathy]. 780 28

The long-term results obtained with the Krupin eye short valve shut in 28 eyes with neovascular glaucoma were retrospectively analyzed by means of Kaplan-Meier survival curve. The preoperative intraocular pressures (IOPs) ranged from 28 to 62 mm Hg (mean, 36.8 +/- 5.8 mm Hg). Success was considered an IOP of less than 22 mm Hg and greater than 5 mm Hg without medication (complete success) or with medication (qualified success) without additional glaucoma filtering surgery or devastating complications. Postoperative success was obtained in 10 out of 28 eyes after a mean follow-up period of 58.4 +/- 23.02 months (range, 10-108 months). The 3- and 6-year life table success rates were 66 and 34%, respectively. Early complications were: shallow or flat anterior chamber (15 patients, 53.6%), hypotony (16 patients, 57.1%), hypertony (7 patients, 25%), serous choroidal effusion (7 patients, 25%), fibrinous uveitis (5 patients, 17.9%), blockage of the intracameral portion of the tube by fibrin (5 patients, 17.9%), choroidal hemorrhage (2 patients, 7.1%). Late complications were: external conjunctival bleb failure (12 patients, 42.9%), blockage of the intracameral portion of the tube by fibrovascular tissue (5 patients, 17.9%), cataract (2 patients, 7.1%), bullous keratopathy (2 patients, 7.1%), external erosion of the Silastic valve (2 patients, 7.1%), phthisis bulbi (2 patients, 7.1%). Mortality during long-term follow-up was high in our series. The complications of an underlying diabetes mellitus were the most common cause of death (15 out of 22 patients). The high mortality of patients subjected to valve implantation makes it difficult to interpret the results of long-term studies. However, the valve implant is still today an alternative surgical procedure for controlling IOP in eyes with neovascular glaucoma that have visual potential.
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PMID:Long-term results of Krupin-Denver valve implants in filtering surgery for neovascular glaucoma. 884 Oct 66


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