Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Testing of the autonomic cardiovascular reflexes (single breath beat-to-beat variation and orthostatic blood pressure change) was performed in 542 patients with erectile dysfunction who were grouped according to aetiological factors and their response to visual sexual stimulation and the papaverine test. Age-related normal values for autonomic tests were determined in the group of 124 patients with psychogenic impotence. Abnormal cardiovascular reflexes were associated with ageing and organic impotence, indicating autonomic dysfunction as a major contribution to impotence. Single breath beat-to-beat variation, as a simple non-invasive test, is useful in the clinical evaluation of impotence, especially in patients with diabetes and a history of alcohol abuse.
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PMID:Cardiovascular reflexes in the neurological evaluation of impotence. 846 55

Penile prostheses have become widely accepted in the management of erectile impotence. We report on 21 patients, aged from 22 and 65 years, who were implanted with AMS inflatable prostheses. Diabetes Mellitus, peripheral vascular disease, radical pelvic surgery and Peyronie's disease were among the most common aetiological factors in our patients. Psychogenic impotence was the indication for implantation in one patient. Two patients developed complications that required explantation of their devices. One additional patient who has a functioning device considers this form of assisted erection too artificial and has declined to use it for aesthetic reasons The AMS inflatable prosthesis effectively restores erectile function when initial conservative therapies have failed.
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PMID:Use of the AMS inflatable penile prosthesis in the management of erectile impotence. 918 94

Penile tissue consisting of corps cavernosum (cc) and tunica albuginea (TA) was obtained from 35 impotent patients undergoing surgery for implantation of penile prostheses and was examined for nor adrenaline content. 10 patients were classified as a non diabetic non neuropathic group, on the basis of their clinical history and differential diagnostic symptoms which included Peyronie's disease, vascular disease, hypertension and psychogenic impotence. The nor adrenaline content was found to be significantly lower in tunica albuginea than the corpus cavernosum (P<0.02) in this group. The nor adrenaline content of corpus cavernosum from insulin dependent (IDDM) and non insulin dependent (NIDDM) diabetic neuropathic patients was also found to be significantly lower (P <0.02) than that of non diabetic non neuropathic patients. The nor adrenaline content of tunica albuginea however, was similar in both groups. A non significant association in the content of nor adrenaline in corpus cavernosum and tunica albuginea among IDDM and NIDDM diabetic neuropathics was also observed. These results provide evidence that an underlying neuropathic factor itself causes vascular as well as metabolic changes in the adrenergic nerves of the penis in diabetics due to neuropathy in addition to the effect of the disease and thus may contribute to the development of impotence in these patients irrespective of their type of diabetes.
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PMID:Estimation of nor-adrenaline content of human penile tissue in diabeticmen with/without neuropathy. 1641 54


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