Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The rarity of hepatic infarction has been explained by the protection from ischaemia provided by the double arterial and portal inflow. Hepatic infarction hence should require the association of multiple factors jeopardizing compensatory mechanisms. We report on a case of hepatic infarction related to combined hepatic arterial and portal venous thrombosis after a blunt abdominal trauma, a previously unreported cause of hepatic infarction. Several causes of vascular impairment were present: shear stress injury due to the trauma, protein C deficiency, type II diabetes and administration of glibenclamide, a splanchnic vasoconstrictor agent. There was repermeation of the portal vein and hepatic artery following anticoagulation therapy. Because hepatic infarction is usually explained by the concurrence of several factors impairing the hepatic blood supply, an extensive search for associated conditions is necessary even when a conspicuous cause is present.
 ...
PMID:Multifactorial aetiology of hepatic infarction: a case report with literature review. 1502 75

Hepatic infarction rarely occurs due to the double supply of arterial and portal inflow. A 53-year-old man with diabetes mellitus developed multiple hepatic infarctions after an episode of fever and diarrhea. The infarction was documented by pathology after partial liver resection. Several causes of hepatic infarction may present in this patient: dehydration and hypotension caused by fever and diarrhea, type 2 diabetes and administration of glibenclamide, diabetic ketoacidosis and widespread atherosclerosis. We suggest that diabetic patient with elevated liver enzyme should be considered the possibility of hepatic infarction.
 ...
PMID:Diabetes mellitus with hepatic infarction: a case report with literature review. 1693 16

Since the liver has a duplicate blood supply through the hepatic artery and portal vein, hepatic infarction is considered a rare disease. A 51-year-old male with acute myeloid leukemia and diabetes mellitus developed fulminant hepatic infarction only a few days after administration of FLAGM chemotherapy. Our case was considered to have been caused by the almost complete obstruction of both the hepatic artery and portal vein by thrombi during a short period. Hepatic infarction should be recognized as a complication that may develop after salvage chemotherapy such as FLAGM inducing marked myelosuppression. Hepatic infarction after chemotherapy requires further analysis by evaluating a larger number of cases.
 ...
PMID:[Massive hepatic infarction occurred during the myelosuppression after re-induction chemotherapy for acute myeloid leukemia]. 2125 91