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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An investigation limited to patients under 70 years of age was undertaken to study the incidence of new cerebrovascular strokes (cerebral hemorrhage, cerebral infarction, and cerebral embolism) in all cases from Uppsala county between 1967-1971. The total incidence of stroke is 36/1000,000 in this age category; the mean age was 59.9 years for men and 60.8 years for women. Of the total number, 25% were recurrences. The occurrence of a moderate but significant decrease during the period of study has been attributed to an extended and improved treatment of hypertension. All of the 6 females who had suffered strokes below 40 years of age had been on oral contraceptives at the time. A high incidence of diabetes and symptoms of cardiovascula r impairment (hypertension, transient ischemic attack, cardiosclerotic disease) was found. A high incidence of myocardial infarction and of strokes was found among parents of those suffering cerebral hemorrhage and cerebral infarctions, respectively.
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PMID:Studies on cerebrovascular stroke. I. Epidemiology of first-time strokes in persons under 70 years of age. 120 87

37 patients below the age of 50 have been observed following acute 1st-time cerebrovascular lesion. Predisposing factors were found in nearly all cases. Hypertension was found to be present in about 1/2 of the patients suffering from cerebral hemorrhage and in 1/4 of those with cerebral infarction, 6 females were on oral contraceptives. Mortality within 1 month was 35% and was essentially caused by a very high mortality among patients with cerebral hemorrhage. A check after 30 months showed that 16 patients were still alive and 11 were able to perform some sort of work. A high incidence of diabetes and impaired glucose metabolism was exhibited among the survivors as seen from intravenous glucose tolerance tests. As compared with higher age groups, those younger stroke survivors have fairly good chances of going back to work. Health surveys, screening of the relatives of patients wi th hypertension or other vascular diseases, and rehabilitative resources are needed to trace possible stroke victims early and to rehabilitate those who have already been stricken.
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PMID:Stroke before fifty. Experiences from a five-year study. 120 88

Fifty-three patients with acute cerebral infarction were treated in a double-blind study with either dexamethasone or placebo within 24 hours of the onset of stroke. Forty-one of these survived for longer than 28 days, and the patients treated with the steroid fared slightly worse than those treated with placebo at the end of this time. Two of the five patients who died in the placebo group died of cerebral edema, compared with three out of seven patients who died in the steroid group. Infectious complications, gastrointestinal hemorrhage, and occasional serious exacerbations of diabetes occurred more commonly in the steroid group.
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PMID:Steroid therapy in acute cerebral infarction. 124 99

Analysis of death certification in North Carolina for a three-year period, 1969 through 1971, showed regional differences in mortality rates from stroke in white men, with the highest rates in the Plains (tobacco growing and farming) area and the lowest rates in the Mountain region. These geographic differences in death rates were observed in all but the youngest age decade and also in the various types of stroke, i.e., hemorrhagic and occlusive cerebrovascular diseases. This regional variation in mortality, however, was not present in white women or blacks. The prevalence at death of heart disease, hypertension and diabetes also was higher in the Plains than in the Mountain region, suggesting that the observed geographic variation of stroke mortality is related to one or more of these major risk factors. It is concluded that the geographic differences in stroke mortality, which had been reported during previous decades, are real and are not due to variations in death certification, errors in diagnosis, or other explanations that might artificially produce inaccuracies in vital statistics.
Stroke
PMID:Geographic differences in mortality from stroke in North Caroline. 1. Analysis of death certificates. 125 3

The association of cigarette smoking and atherosclerorosis was investigated in 1320 autopsied men, 25--64 years of age. Aortic and coronary lesions were evaluated visually in coded specimens and objectively by analysis of radiographs. Using schedules that had been tested on pairs of living persons, interviewers obtained estimates of cigarette smoking habits of the deceased men from surviving relatives. Data were analysed for black and white men in the total sample of cases and also in groups according to the presence (selected disease group) or absence (basal group) of diseases thought to be associated with smoking (emphysema, lung cancer, etc.) or with coronary heart disease (myocardial infarction, hypertension, diabetes, stroke, etc.). Atherosclerotic involvement of aorta and coronary arteries was greatest in heavy smokers and least in nonsmokers for both races in the total sample of cases, the basal group and the selected disease group.
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PMID:Cigarette smoking and atherosclerosis in autopsied men. 126 63

Factors which best predict mortality within five years have been examined in a random community sample of 852 people over 65. Apart from sex, multiple-regression analysis shows the best predictive factors to be higher age and the occurrence of proteinuria in both sexes. In men, low vitamin c intake and an unfavourable clinician's assessment of the subject's health were also significant predictors. In women, whether the subject was housebound, the diagnoses of stroke and of diabetes and a low serum pyridoxine were additional adverse factors. The findings regarding low vitamin C intake in men and low serum pyridoxine levels in women should be regarded with caution. The former appears unlikely to represent a true vitamin deficiency effect and whilst the latter might, the evidence is no more than suggestive and further confirmatory studies are required.
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PMID:Factors predicting mortality in the elderly in the community. 127 97

A 49-year-old with long-standing hypertension and diabetes developed numbness and sensory loss over the left side of the body consistent with a diagnosis of Pure sensory stroke (PSS). However, CT showed a subcortical infarction in the middle cerebral artery (MCA) territory, which evolved a few hours later towards a large hemispheric infarction associated with severe neurologic worsening. Doppler ultrasounds showed ipsilateral carotid occlusion and contralateral severe stenosis. These findings suggest that PSS may sometimes herald large infarction in the MCA territory in association with carotid occlusion.
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PMID:Pure sensory stroke heralding large hemispheric infarction. 127 92

We reported the first case of angiotropic lymphoma diagnosed by adrenal biopsy in Japan. Immunohistochemical study and southern blot hybridization analysis proved it to be B-lymphocyte origin. A 61-year-old man with history of mild hypertension and diabetes mellitus was admitted to our department because of recurrent minor stroke. On admission, general physical findings were normal. Laboratory investigations showed an elevated erythrocyte sedimentation rate and increased serum lactic dehydrogenase (LDH) level. The serial computed tomographic (CT) scan of the brain showed multifocal abnormal density lesions in bilateral hemispheres. Magnetic resonance imaging (MRI) of the brain demonstrated multiple lesions of increased signal intensity in the brainstem and bilateral hemispheres. A subsequent CT scan of the abdomen revealed swelling of bilateral adrenal glands. Adrenal biopsy was performed. Biopsy samples showed the intravascular proliferation of malignant lymphoma cells, non-Hodgkin, diffuse large cell type. These cells had the immunophenotype of a B cell lymphoma (reactive with the antileukocyte common antigen, anti-MB-1, anti-MB-2 and anti-MX-pan B, and unreactive with the anti-MT-1, anti-UCHL, anti-Ki, anti-kappa, anti-lambda and antifactor-VIII). Southern blot hybridization analysis showed monoclonal rearrangements of the immunoglobulin heavy-chain gene, which strongly suggested a B-lymphocyte origin. Thus, a diagnosis of angiotropic lymphoma was made. As soon as chemotherapy was begun, the patient fell into deep coma. A repeat CT scan of the brain was normal. His clinical status gradually deteriorated, and he died 18 months after his initial symptom. Autopsy, which was limited to the body, revealed characteristic systemic intravascular stagnation of lymphoma cells.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[A case of angiotropic lymphoma diagnosed by adrenal biopsy]. 129 Nov 69

In order to investigate risk factors of ischemic stroke, a matched case-control study with two kinds of controls (community controls and hospital controls) was conducted. The multiple conditional logistic regression analysis showed that hypertension, transient ischemic attacks, alcohol consumption and habitual snoring were independent risk factors of ischemic stroke. Physical activity at leisure time was an important protective factor. No independent relationships were found between cigarette smoking, history of mellitus diabetes or heart diseases, stroke history of father or mother and ischemic stroke.
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PMID:[A study on risk factors of ischemic stroke]. 130 14

The centrum ovale, which contains the core of the hemispheric white matter, receives its blood supply from the superficial (pial) middle cerebral artery (MCA) system through perforating medullary branches (MBs), which course toward the lateral ventricles. Though vascular changes in the centrum ovale have been emphasized in dementia, stroke from acute infarction in the centrum ovale is less well documented. We studied 36 patients with infarct limited to MB territory, without involvement of the lenticulostriate territory. Ten patients had a large infarct, associated with severe disease of the ipsilateral carotid artery and with neurologic-neuropsychological impairment not different from that of large MCA infarcts. In 26 patients, the infarct was small and round or ovoid, and was associated with hypertension or diabetes and with "lacunar syndromes," usually of progressive onset. These findings show that two forms of centrum ovale infarcts can be delineated according to infarct size and shape, clinical picture, risk factors, and associated vascular disease. We propose to classify subcortical infarcts in the carotid system into four main territory groups: (1) deep perforator territory (from the MCA trunk, carotid siphon, anterior choroidal artery, anterior cerebral artery trunk, Heubner's artery, and posterior communicating artery); (2) perforating MB territory (from the superficial MCA branches); (3) junctional (territory between 1 and 2); and (4) combined territories.
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PMID:Centrum ovale infarcts: subcortical infarction in the superficial territory of the middle cerebral artery. 835 Oct 32


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