Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Amniotic fluid concentrations of 3,3',5'-tri-iodothyronine (rT3), 3,3'-Di-iodothyronine (3,3'-T2), 3,5,3'-tri-iodothyronine (T3) and T4 were studied in 384 women during normal and complicated pregnancy. An inverse correlation was observed between decreasing rT3 and increasing 3,3'-T2 concentrations in amniotic fluid with gestational age. The mean rT3 level in normal pregnancy was 2.81 nmol/1 at 12-20 weeks and decreased significantly to 1.06 nmol/1 at 36-42 weeks of gestation. The mean 3,3'-T2 concentration was 49.1 pmol/1 at12-20 weeks increasing to 119 pmol/1 at 36-42 weeks. The mean T4 value of 3.83 nmol/1 at 12-20 weeks was about half that of later periods. The T3 concentration in a random sample of 45 amniotic fluids ranged from less than 28 to 370 pmol/1 (mean 102 pmol/1). The mean rT3, 3,3'-T2 and T4 values measured in patients with intra-uterine malnutrition, gestation diabetes, tocolysis, placental insufficiency and rhesus incompatibility at 31-40 weeks of gestation were not significantly different from those in uncomplicated pregnancy. Significantly decreased rT3 and T4 concentrations were found in toxaemia. From the results obtained in complicated pregnancy it may be concluded that measurements of iodothyronines, especially rT3, in amniotic fluid have insignificant diagnostic value in the recognition of intra-uterine lesions with the probable exception of fetal hypothyroidism. The analysis of the dependence of iodothyronine concentrations on the gestational age showed a maximum of rT3 and T4 levels between 20 and 30 weeks of pregnancy. This marked rise of iodothyronine concentrations in amniotic fluid at mid-gestation may be due to the onsetting maturation of the hypothalamic-pituitary-thyroid control system of the fetus.
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PMID:Amniotic fluid concentrations of 3,3',5'-tri-iodothyronine (reverse T3), 3,3'-di-iodothyronine, 3,5,3'-tri-iodothyronine (T3) and thyroxine (T4) in normal and complicated pregnancy. 47 70

Sacral agenesis is an uncommon condition associated with familial diabetes mellitus and complicated pregnancy. The condition is characterized by gluteal skin dimpling, loss of gluteal fold, myelomeningocele, sacral lipoma, as well as numerous orthopedic, anorectal and other widespread anomalies. The motor nerve deficit, for example poor anal sphincter tone, is more pronounced than the sensory nerve deficit, for example perianal anesthesia. Diagnosis is made by anteroposterior and lateral spinal x-rays. All of our patients had bladder or external sphincter dysfunction, while 91 per cent had vesicoureteral reflux. Early diagnosis and conservative management with intermittent catheterization and uropharmacological agents are now advocated.
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PMID:Sacral agenesis: an analysis of 11 cases and review of the literature. 50 26

171 samples of amniotic fluid were obtained by abdominal amniocentesis from 67 women with complicated pregnancies (isoimmunization, diabetes mellitus or toxaemia). The levels of heat-labile alkaline phosphatase (HLAP), heat-stable alkaline phosphatase (HSAP) and acid phosphatase (AcP) were determined and compared to the enzyme levels in 179 samples from women with normal pregnancies of corresponding gestational ages. HLAP showed two "peaks" of activity, one in the 5th-22nd week and the other at term. HSAP and AcP showed increased activity at term. HSAP was decreased (p less than 0.01) in isoimmunization between the 36th and 40th week. 11 cases of toxaemia with placental insufficiency showed no differences in the levels of HLAP and HSAP compared with normal pregnancy. AcP showed no differences between normal and complicated pregnancy. Samples contaminated by blood showed no significant increase in the acid- and alkaline phosphatase levels. Samples contaminated by meconium showed a complex pattern. Some samples had normal enzyme levels, some had high levels of HLAP only and some had high levels of HSAP and AcP. The origin of the enzymes is not known with certainty. HSAP in amniotic fluid is most likely not of placental but intestinal origin. Determinations of acid- and alkaline phosphatase in amniotic fluid seem to be of little values in the clinical management of complicated pregnancy.
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PMID:Acid- and alkaline phosphatase in amniotic fluid in normal and complicated pregnancy. 62 87

The average estradiol concentrations in umbilical cord plasma from newborns which developed respiratory distress with or without hyaline membrane disease (RDS) were lower by 25% than in controls. Complication of pregnancy by maternal diabetes or pruritus has been associated with abnormalities in estrogen concentrations in the mother, but cord plasma estradiol levels in these cases were essentially normal. Because of reports that treatment of the mother before delivery with estrogens or glucocorticoids results in a decreased incidence of RDS in newborns the relationship between endogenous estradiol and cortisol levels in cord plasm was investigated. There was no significant correlation between the concentrations of these steroids in 65 specimens; the cortisol levels associated with two cases of severe RDS were low.
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PMID:Umbilical cord plasma estradiol levels in relation to complications of pregnancy and newborn and to cortisol levels. 117 1

The fibrinolytic response to venous occlusion was assessed in 29 women with normal or complicated pregnancy, by measurements of total t-PA and free t-PA with specific ELISAs. The release of t-PA from the vessel wall was 11 +/- 9 ng/ml in non-pregnant women (mean +/- SD, n = 6) but was markedly reduced throughout pregnancy. Following venous occlusion, free t-PA increased by 12 +/- 11 ng/ml in non-pregnant women but remained below the detection limit of 2 ng/ml towards the end of pregnancy. A markedly reduced t-PA release with absence of free t-PA was also observed during late pregnancy in patients with insulin-dependent diabetes mellitus, intra-uterine growth retardation and pre-eclampsia. Plasma levels of fragment D-dimer of cross-linked fibrin were measured with a specific ELISA in 79 pregnant women. D-dimer levels were 129 +/- 36 ng/ml (mean +/- SD, n = 8) in non-pregnant women and increased to 400 +/- 170 ng/ml (n = 25) and 440 +/- 220 ng/ml (n = 22) during the second and third trimester of pregnancy respectively. Significantly higher levels than observed in uncomplicated third trimester pregnancies were found in 3 out of 6 diabetic and in 2 out of 7 pre-eclamptic women. It is concluded that the t-PA release after venous occlusion is significantly reduced during pregnancy. In addition, released t-PA is rapidly inhibited. The levels of fragment D-dimer increase during pregnancy, suggesting that, notwithstanding the marked impairment of the fibrinolytic response to venous occlusion, the fibrinolytic system remains functionally active.
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PMID:Fibrinolytic response to venous occlusion and fibrin fragment D-dimer levels in normal and complicated pregnancy. 344 23

In response to a recent editorial advocating use of prostaglandins (PGs) for preterm labor induction in women with essential and renal hypertension, preeclampsia, growth-retarded fetuses, diabetes, and rhesus incompatibility, this letter questions the logic of such a recommendation. Given that PGF2 alpha has been shown to have a vasconstrictive effect on placental veins and on umbilical arteries; that hypertensive states in pregnancy may cause pathological lesions in uteroplacental arteries; and that preeclampsia involves an inadequate response of the uteroplacental arteries to placentation; PG induction of labor may exacerbate the conditions of complicated pregnancy which necessitated labor induction in the first place. Use of PGs for premature induction of labor in pregnancies by hypertensive states, and perhaps in other conditions associated with intrauterine hypoxia, may aggravate fetal distresses. The letter suggests that in vitro biopsy studies of human pregnanted uterus need to be perform to investigate the action, if any, of PGs on myometrial blood vessels before PGs can be recommended for premature labor induction in cases of hypoxia and fetal distress.
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PMID:Letter: Prostaglandins and induction of labour. 413 41

6059-S, a new oxacephem antibiotic was applied in the clinical use of gynecological and obstetrical infection. 1. In obstetrical field, attention should be paid on choice of antibiotics in the case of maternal infection. Especially in the trimester of pregnancy, such drugs as ampicillin (ABPC) has been reported apparent unfavourable effects by decreasing the estriol (E3) level. 2. The comparative study between 6059-S, SBPC and ABPC was performed by various hormone level, including E3 (blood and urine), blood progesterone, alpha-fetoprotein, human chorionic gonadotropin (HCG), cortisol and human placental lactogen (HPL). 9 cases of intrauterine fetal growth retardation (IUGR) (ranging from 28 approximately 36 weeks of pregnancy) was selected, including toxemia of pregnancy or complicated pregnancy of myoma of uterus and diabetes mellitus. The determination of hormone level, one drug (2g) out of three test drug was chosen at random and administered by intravenous infusion on 3 approximately 4 days after admission. After 5 days of interval, another test dose was given, and the evaluation between the drug effects was performed on the hormonal level. 3. Following the single administration of ABPC (2 g) by intravenous infusion, the decrease of urinary E3 reached 26% on the 2 days after injection. As for SBPC the decrease was 21%, while in cases 6059-S, no apparent change was determined. Statistical difference between 6059-S and ABPC 5% by chi 2 determination was found. On the other hormonal level, there was relatively great individual difference, and the apparent day by day change was undeterminable. 4. Clinical estimation of 6095-S on the gynecological infection was also performed on the 7 cases of patients. The overall efficacy rate was 85.7%. No adverse reaction was observed except one case elevation of S-GPT.
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PMID:[Clinical application of 6059-S in the field of obstetrics and gynecology. Effects on gynecological infection and infection of trimester of pregnancy (author's transl)]. 645 70

During a 3-year period, 377 samples of amniotic fluid, free of blood and meconium and obtained from a total of 471 patients, were examined by the fluorescence polarization technique to estimate fetal lung maturity. Fluorescence polarization values of 287 samples from normal and abnormal pregnancies were correlated with gestational age. A total of 272 pregnancies comprising cases complicated by toxemia, placental insufficiency, placenta previa, premature contractions, and diabetes mellitus, and including a control group of 37, were studied to discern the effect of such pathologic conditions on the usual decline of fluorescence polarization (FP) values with increasing gestational age. No complicated pregnancy had values significantly different from those of the control group, except for pregnancies complicated by diabetes mellitus. The threshold of fetal lung maturity as related to respiratory distress syndrome (RDS) was determined in correlation with the lecithin: sphingomyelin (L:S) ratio. FP values of 0.311 +/- .005 corresponded to an L:S ratio of 2.0. An FP value of 0.316 +/- .005 is recommended as a practical threshold related to the clinical outcome of the newborn as regards RDS. The technique was found reliable, simple, and accurate and has been of great value in the antenatal diagnosis of fetal lung maturity.
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PMID:Determination of fetal lung maturity from amniotic fluid microviscosity in high-risk pregnancy. 707 Jul 35

The long-term outlook of patients with brittle insulin-dependent diabetes is uncertain. We assessed the outcome of a group of young female patients with diabetes and recurrent ketoacidosis originally investigated in 1979-85 and reassessed after a mean of 10.5 (SD 1.4) years. 7 of the 33 patients could not be traced. 5 (19%) of the remaining 26 had died. Causes of death were not certain, but were probably ketoacidosis (2), hypoglycaemia (2), and renal failure (1). Of the 21 survivors, only 2 (10%) were still considered to have brittle diabetes. Diabetic complications were common (67%), and were more frequent than in a matched control group of stable patients with diabetes (25%). Brittle diabetic patients also had lower quality-of-life scores, more frequent psychosocial disruptions, and were on higher insulin doses (77 [39] vs 47 [15] U per day, p = 0.007) than controls. Pregnancy complications had occurred in 13 of 28 (46%) pregnancies in severely unstable patients compared with 2 of 27 (7%) in stable controls. Patients with brittle diabetes have a tendency to become more stable with time, but have a higher risk of death, more microvascular and pregnancy complications, and a poorer quality of life.
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PMID:Mortality and outcome of patients with brittle diabetes and recurrent ketoacidosis. 791 65

The purpose of the study was to investigate an association between maternal and/or fetal complications during pregnancy and/or delivery and the occurrence of baby bottle tooth decay (BBTD) in the infant. The study population comprised 50 mothers of infants with BBTD (BBTD+ mothers): 50 mothers of aged-matched children with similar eating and bottle-use habits but without BBTD (BBTD-) served as comparisons. Interviews with the mothers focused on pregnancy complications (vaginal bleeding, premature uterine contractions, viral or bacterial infections, hospitalization, diabetes, or other causes of high-risk pregnancy), mode of delivery (normal or instrumental), fetal distress, gestational age, birth weight, and mother's age at delivery. Chi-square analysis and the Student's t-test were used to analyze the data. Pregnancy complications and instrument delivery/cesarean section were significantly higher in the BBTD+ group than in the controls (P = 0.0001 and P = 0.0004, respectively). In the BBTD+ group, vaginal bleeding/premature uterine contractions were most frequent (50%), while in the BBTD- group high-risk pregnancy dominated (20%). Normal deliveries were more frequent in the BBTD+ mothers (68%) than in the comparisons (40%). Gestational age and baby's birth weight did not differ between the two groups. The mean age of the BBTD+ mothers was significantly lower than that of the controls (P = 0.013). The results suggest that babies born after maternal complications during pregnancy or babies who experience a traumatic birth must be considered to be at risk of developing BBTD when exposed to excessive bottle nursing.
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PMID:Baby bottle tooth decay and complications during pregnancy and delivery. 904 11


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