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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cell-mediated and humoral immune responses were assessed in 50 patients with type II or non-insulin-dependent diabetes mellitus and 50 nondiabetic patients with periodontitis. The values were compared with those of 50 age and sex-matched control subjects. The cell-mediated immunity assessed by enumerating the total and high-affinity rosette-forming cells of the patient did not show any significant variation from that of the normal control subjects. The humoral immune response was assessed by estimating serum immunoglobulins G, A, M, D, and E by single radial immunodiffusion. Except IgD, all other immunoglobulins were found to be elevated significantly in both diabetic and nondiabetic subjects. The alteration in humoral immune response may be the cause or the effect of periodontitis. The defective host response reported in diabetic patients may be responsible for the increased incidence of periodontitis in diabetic patients as compared to nondiabetic patients.
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PMID:Cell-mediated and humoral immune response in diabetic patients with periodontitis. 237 Oct 49

The prevalence of periodontitis was studied in a population of 157 insulin dependent diabetes mellitus patients aged 8-78 years attending the outpatients diabetic clinic of a large general hospital in Cork, Ireland. Every third diabetic patient attending the clinic was selected for examination. The dental parameters measured were plaque index (PI), gingivitis index (GI), periodontal pocket depth (PD) and periodontal attachment loss (PAL). Diabetic control was measured by estimating percentage haemoglobin glycolysation (% Hb Alc) known duration of diabetes (KDD) and insulin dependence. It was found that none of the diabetic measurements showed any consistent pattern in relation to any of the periodontal measurements. The findings are in agreement with other studies which suggest that no significant correlation between diabetic parameters and periodontal disease can be demonstrated. When the diabetic patient suffered periodontitis it was due to factors (such as genetic predisposition) other than impaired glucose metabolism.
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PMID:Diabetes mellitus and periodontal disease in an Irish population. 253 53

Systemic diseases--like diabetes mellitus--are able to injure the local and common resistance of an organism. Therefore we must expect a more intensive and severer progress of gingivitis and periodontitis in diabetic patients in comparison with a non-diabetic control-group. On the Gondar College of Medical Sciences in Northwest-Ethiopia are investigated 77 Insulin-obliged diabetics and 312 persons for control by means of the plaque-Index, the Oral-Hygiene-Index simplified. The DMF/T-Index and the Gingivitis-respectively Periodontal-Disease-Index for evaluation of the oral health situation. The comparison shows that the diabetic group has a moderate higher Plaque-pictures of gingivitis or periodontitis. This confirms our opinion that the diabetes mellitus is a risk-factor for the development of periodontal diseases. Therefore patients with diabetes mellitus should perform a very intensive care for mouth-hygiene.
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PMID:[Report on experiences with a one-year action at the Gondar College of Medical Sciences in Ethiopia. 3. Influence of diabetes mellitus on the teeth supporting apparatus]. 263 34

A study is made of a group of 67 persons with diabetes mellitus, over 15 years of age, in order to know the presence and severity of periodontal disease, in relation with degree of oral hygiene, age, duration of the course and degree of metabolic control of diabetes. It was shown that 85.1% of the cases had some form of the periodontal disease, the most frequent of which being advanced periodontitis (34.3%). 100% of the patients had an inadequate oral hygiene. Lack of metabolic control, age and degree of oral hygiene correlated positively with the severity of periodontal disease.
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PMID:[Relation between periodontal disease and diabetes mellitus]. 264 Mar 32

Inflammatory periodontal diseases are common in the United States. The incidence of gingivitis and periodontitis appears to be the same for persons with controlled diabetes as for those in the nondiabetic population. For patients with uncontrolled diabetes, however, periodontal diseases progress more rapidly than in their controlled counterparts. In addition, once a person with diabetes has periodontitis, the disease is usually more aggressive than in nondiabetic controls. These differences may be due to microangiopathy, altered polymorphonuclear leukocyte chemotaxis, increased dental plaque formation, or other causes. Patients with diabetes should be counseled to have a periodontal screening, which must include the use of a probe to measure the depth of the periodontal pockets. When problems are found, they should be treated and the patient should be placed in maintenance therapy.
Diabetes Educ
PMID:Periodontal diseases and diabetes. 267 37

IgG antibody levels to lipoteichoic acid (LTA), prepared from Streptococcus mutans cells, were determined by enzyme-linked immunosorbent assay in serum samples from 149 subjects. An extract from Bacteroides gingivalis and lipopolysaccharide from Escherichia coli 055:B5 served as control antigens. The reference group comprised 28 systemically and periodontally healthy adults. The main test groups were: 52 persons with gingivitis only, and 69 patients with periodontitis. Within those groups, 37 patients had insulin-dependent diabetes mellitus, another 20 patients were prospective or renal transplant recipients. The periodontitis patient group showed significantly (p less than 0.05) higher mean antibody value and higher frequency of extreme antibody responses to both LTA and B. gingivalis than the gingivitis group. LPS did not discriminate between the groups. Multiple regression analysis with gingivitis scores as the dependent variable selected plaque scores, anti-LTA antibody values and general health status as significant (p less than 0.05) regressors. The variance in radiographical alveolar bone loss was significantly (p less than 0.05) explained by age and by antibody values to B. gingivalis and to LTA. The patients with extreme immunological responsiveness to LTA or to B. gingivalis had about twice as much alveolar bone loss as those with normal serological reactivity. The results support the contention that LTA modulates the progression of periodontitis in humans.
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PMID:Serum IgG antibodies reactive with lipoteichoic acid in adult patients with periodontitis. 277 86

Oral affections are important causes of disorders in diabetes, within them, periodontal disease is the most common one, which comprises gingivitis and periodontitis. Dental plaque, high concentrations of salivary calcium and glucose, hyperglycemia and a lower resistance to infections, are main factor contributing to periodontal disease, dental caries, mycotic stomatitis and aphthae. Even though with the most advanced surgical methods and using antibiotics, systematically, the treatment of periodontal disease is rather difficult and often unsuccessful, therefore, to prevent it is the best treatment available, hence the importance of teaching oral health to the diabetic patient, which should comprise a good metabolic control, right tooth-brushing and visits to the stomatologist every six months or in the presence of gingival bleeding or gingival pus emanation. Diabetic condition is not a contraindication for the extraction of carious dental teeth, on the contrary, such teeth must be extracted when required or adequately treated.
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PMID:[Detection and prevention of oral complications in diabetics]. 297 96

This study was designed to evaluate the relationship of inflammatory periodontal disease to the diabetic status of the insulin-dependent diabetes mellitus (IDDM) patient. 52 IDDM patients, ages 11-22 years, were evaluated. These patients were closely monitored at regular intervals in the University of Kentucky pediatric diabetic clinic. A periodontal examination was carried out for each patient. The patients were then assigned to a periodontitis or non-periodontitis group. Moderate to advanced periodontitis was found in 5.8% of the subjects. The gingival index and sulcular bleeding index were significantly higher in the periodontitis group (P less than 0.05). There was no significant difference between groups for plaque index, age of diabetic onset, duration of diabetes, present age, insulin dosage/weight, or serum glucose (P greater than 0.05). There was a greater % of ketoacidosis, retinopathy and neuropathy in the periodontitis group. IDDM patients with neurological complications or a history of chronic infections had a significantly higher gingival index score than those without the complication (P less than 0.05).
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PMID:The relationship of inflammatory periodontal disease to diabetic status in insulin-dependent diabetes mellitus patients. 314 83

Various systemic diseases and conditions have been associated with an increase in periodontal disease severity. These studies indicate that host-response mechanisms influence the initiation and/or progression of inflammatory periodontal diseases. Diseases that have been associated with an increased severity of periodontal disease include various neutrophil abnormalities, Down's syndrome, diabetes, and recently, the acquired immunodeficiency syndrome. Sickle cell disease is strongly associated with a predisposition to various infections; therefore, the objective of this study was to determine whether sickle cell disease is also associated with an increase in the severity of periodontal disease. A total of 78 patients with sickle cell anemia (SS), hemoglobin SC disease (SC) or S Thalassemia were evaluated blind and compared with an appropriate control population using clinical and radiographic indices of periodontal disease severity. The results clearly indicate that, in this population of patients, sickle cell disease is not associated with increased levels of gingivitis or periodontitis.
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PMID:Periodontal disease in sickle cell disease subjects. 316 81

Dental and oral examinations of 1360 patients with diabetes mellitus showed higher DMFT mean values with fewer carious teeth and more filled and extracted teeth than the controls. PI mean values were higher in diabetics than in the controls, the difference being statistically significant, and showed a positive correlation with age, but no correlation with the length of time since the disease was established. No correlation was found between the severity of gingivitis and changes in blood glucose levels. The sucrose-free diet of diabetics does not seem to reduce caries prevalence. The increased DMFT index is explained by the fact that, due to periodontitis, diabetics lose more teeth sooner than do healthy people.
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PMID:Dental and oral symptoms of diabetes mellitus. 320 98


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