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The prevalence of myopia is high in many parts of the world, particularly among the Orientals such as Chinese and Japanese. Like other complex diseases such as diabetes and hypertension, myopia is likely to be caused by both genetic and environmental factors, and possibly their interactions. Owing to multiple genes with small effects, genetic heterogeneity and phenotypic complexity, the study of the genetics of myopia poses a complex challenge. This paper reviews the current approaches to the genetic analysis of complex diseases and how these can be applied to the identification of genes that predispose humans to myopia. These approaches include parametric linkage analysis, non-parametric linkage analysis like allele-sharing methods and genetic association studies. Basic concepts, advantages and disadvantages of these approaches are discussed and explained using examples from the literature on myopia. Microsatellites and single nucleotide polymorphisms are common genetic markers in the human genome and are indispensable tools for gene mapping. High throughput genotyping of millions of such markers has become feasible and efficient with recent technological advances. In turn, this makes the identification of myopia susceptibility genes a reality.
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PMID:A review of current approaches to identifying human genes involved in myopia. 1804 48

The functional and clinical results of implantation of various models of intraocular lenses (IOL) were assessed, by taking into account its procedure (applying a forceps or an injector). The optimum technology for implanting elastic IOLs was proposed, depending on the etiology of cataract. Analysis of surgical outcomes in 172 patients (207 eyes) revealed the characteristic complications, the specificity of implantation of various models of elastic IOLs, the advantages and disadvantages of the forceps- and injector-based implantations in age-related cataract, in patients with complicated cataracts in the presence of glaucoma, myopia, diabetes, and moderate- and high-degree hyperopia.
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PMID:[Optimization of elastic intraocular lens implantation technology in the phacoemulsification of different types of cataract]. 1822 21

A 49 y/o female under went 48 hyperbaric oxygen (HBO2) treatments at 2.5 ATA (atmospheres absolute) (253 kPa) for 90 minutes for chronic refractory osteomyelitis of the sacrum and recurrent failure of a sacral myocutaneous flap. Prior to HBO2 therapy, formal ophthalmic exams revealed myopia but no evidence of cataract formation. Eight weeks following the completion of HBO2 therapy, on repeat ophthalmic exam, the patient was discovered to have worsening myopia. Changes of the crystalline lens, consistent with nuclear cataract development, were identified in each eye. Other common causes of cataract formation including diabetes, corticosteroid use, and excessive exposure to ultraviolet light, were excluded. While transient visual changes are known to occur during HBO2 therapy, cataract formation has only rarely been reported and only after prolonged courses of treatment (150 or more treatments). This case identifies the need to further investigate the ocular effects of HBO2 therapy, especially with regard to cataract development and progression.
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PMID:De novo cataract development following a standard course of hyperbaric oxygen therapy. 1825 34

Two hundred and fifty patients aged 25 to 50 years were examined. Arterial hypertension (AH) was diagnosed in 144 persons; its mean history was 4.35 +/- 0.5 years. Insulin-independent diabetes mellitus (IIDM) and AH were observed in 71 patients; the mean history of IIDM was 3.43 +/- 0.3 years. The patients were diagnosed as having eye diseases: mild myopia and hyperopia, first- and second-degree hypertensive angioretinopathy, and diabetic angiopathy. The purpose of the study was to assess treatment compliance for eye diseases in patients with AH and IIDM in relation to the psychological status. Treatment compliance for eye diseases in patients with AH and IIDM was found to be poor. Mild depression had no significant impact on treatment compliance for eye diseases. The patients with IIDM and diagnosed eye abnormalities without signs of depression were ascertained to take drugs to stabilize visual functions more frequently than those with eye abnormalities and AH.
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PMID:[Treatment strategy for the organ of vision in patients with somatic diseases in relation to the psychological status]. 1920 2

Using flat shoes with no heels results in stronger eccentric contractions of plantar flexors, which stimulate the rostral parts of the cerebellar vermis. The stimulation inhibits the limbic structures and increase neurogenesis. Physical activity often involves walking. Eccentric contractions during dorsal flexion of the plantar flexors in the stance phase of walking give rise to tension signals from Golgi tendon organs. The signals from the eccentric contractions are brought to the rostral parts of the cerebellar vermis. Electrical stimulation of the vermis inhibits the limbic structures and increases neurogenesis, and so do the signals from eccentric contractions. The use of heeled shoes results in less eccentric contractions with decreased neurogenesis. People in the Western World wore heeled shoes from the beginning of the 17th century, and, because of the decreased neurogenesis, the prevalence of diseases such as depression, epilepsia, Alzheimer's disease, Parkinson's disease, schizophrenia, diabetes, and myopia increased. Use of flat shoes produces stronger eccentric contractions and increases neurogenesis. This would lead to better protection from a range of diseases. Even therapy is possible.
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PMID:Physical activity, eccentric contractions of plantar flexors, and neurogenesis: therapeutic potential of flat shoes in psychiatric and neurological disorders. 1936 29

We report on a 25-year-old woman with pronounced generalized lipodystrophy and a progeroid aspect since birth, who also had Marfan syndrome (MFS; fulfilling the Ghent criteria) with mild skeletal features, dilated aortic bulb, dural ectasia, bilateral subluxation of the lens, and severe myopia in addition to the severe generalized lipodystrophy. She lacked insulin resistance, hypertriglyceridemia, hepatic steatosis, and diabetes. Mutation analysis in the gene encoding fibrillin 1 (FBN1) revealed a novel de novo heterozygous deletion, c.8155_8156del2 in exon 64. The severe generalized lipodystrophy in this patient with progeroid features has not previously been described in other patients with MFS and FBN1 mutations. We did not find a mutation in genes known to be associated with congenital lipodystrophy (APGAT2, BSCL2, CAV1, PTRF-CAVIN, PPARG, LMNB2) or with Hutchinson-Gilford progeria (ZMPSTE24, LMNA/C). Other progeria syndromes were considered unlikely because premature greying, hypogonadism, and scleroderma-like skin disease were not present. Our patient shows striking similarity to two patients who have been published in this journal by O'Neill et al. [O'Neill et al. (2007); Am J Med Genet Part A 143A:1421-1430] with the diagnosis of neonatal progeroid syndrome (NPS). This condition also known as Wiedemann-Rautenstrauch syndrome is a rare disorder characterized by accelerated aging and lipodystrophy from birth, poor postnatal weight gain, and characteristic facial features. The course is usually progressive with early lethality. However this entity seems heterogeneous. We suggest that our patient and the two similar cases described before represent a new entity, a subgroup of MFS with overlapping features to NPS syndrome.
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PMID:Marfan syndrome with neonatal progeroid syndrome-like lipodystrophy associated with a novel frameshift mutation at the 3' terminus of the FBN1-gene. 2097 88

Cataract facoemulsification with continuous anterior capsulorhexis and foldable intraocular lens implantation into the capsular bag has become basic, standard method in cataract surgery and curvilinear capsulorhexis s the most common technique for opening the anterior lens capsule. The opening, made during the operation, within several months of postoperative evolution gradually constricts and in extreme cases it may even close completely. That course of healing is not desirable because of evoking a noted impairment of vision. Decreasing in the anterior capsule opening is observed mostly in eyes with weakened lens zonules. It happens in high myopia, retinitis pigmentosa, diabetes mellitus, retinopathia diabetica, pseudoexfoliation syndrome, uveitis and people of well advanced age. Inspired by observation of a particular, quite drastic case of capsule contraction syndrome, we attempted to analyze the causes, pathogenesis, risk factors, clinical course, prevention and treatment of options for that syndrome.
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PMID:[Anterior capsule contraction syndrome after cataract phacoemulsification surgery]. 2112 Nov 29

Physicians often conduct research on other occupations' health or general populations' health, but their health has hardly been studied systematically. The authors conducted a cross-sectional descriptive survey on 440 physicians systematically selected from their medical license numbers. The response rate was 86.4% (380 out of 440). Two-hundred and twenty-nine were male, and 151 were female. Their average age was 40.8 years (range: 22-74). Most of them were Buddhists (93.9%), specialists (64.2%), married only once and still lived with their spouses (59.5%), and concurrently practiced medicine (95.5%). Their overall satisfaction as physicians was 60.2% high, and 37.2% moderate. Their average sleep time was 6-8 hours per night for 58.9%. Most had eye problems (74.9%) and most were refractive errors such as myopia. Most (63.8%) of them did not have any prevalent diseases. Whereas those who had diseases had (in order) allergy, hypertension, asthma, diabetes, and cancer. Their current illnesses included respiratory tract infection. Most physicians did not smoke (94.2%) nor drink alcohol (70.5%). Most of them were not vegetarians (60.4%), did not eat fast food (99.2%). Interestingly, 41.4% of them were accounted for spending less than twice per week for exercise. As expected, 23.7% of them were exposed to blood, 14.5% to respiratory tract secretion, and 13.7% to pus/secretion from wounds. This study serves as a basis for health promotion approach to medical community and does create awareness of health among Thai physicians.
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PMID:Thai physicians health survey. 2121 85

Glaucoma is an insidious eye disease, potentially putting 4% of older Australians at risk of blindness, unless detected sufficiently early for initiation of effective treatment. This paper reports on the strengths of evidence and glaucoma risk factors that can be identified by primary health care providers from a patient's history. A comprehensive search of peer-reviewed databases identified relevant secondary evidence published between 2002 and 2007. Risk factors that could be determined from a patient's history were identified. A novel glaucoma risk factor reference guide was constructed according to evidence strength and level of concern regarding risk of developing glaucoma. The evidence is strong and consistent regarding the risk of developing glaucoma, and elevated intraocular pressure, advancing age, non-Caucasian ethnicity and family history of glaucoma. There is moderate evidence of association with glaucoma, and migraine, eye injury, myopia and long-term use of corticosteroids. There is conflicting evidence for living in a rural location, high blood pressure, diabetes and smoking. Early detection of people at risk of developing glaucoma can be initiated using our risk factor guide coupled with a comprehensive patient history. Timely future assessment and subsequent management strategies for at-risk individuals can then be effectively and efficiently actioned.
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PMID:Risk factors for glaucoma: what do they really mean? 2189 59

The posterior vitreous detachment consists in the separation between the posterior vitreal cortex and internal limiting membrane of the retina. This is the peak of the vitreal para-physiological age-related modifications. This problem occurs in 6% of normal people of age between 45 and 65 years and in 65% of individuals between 65 and 85 years. Several elements can be responsible for vitreous modifications, such as senility, myopia, aphakia, pseudophakia, diabetes, degeneration vitreous retinal hereditary, traumatisms, inflammation. A 75 year old male patient has come to our attention for a left eye cataract. He has undergone to a series of OCT: the first before surgery showed a perifoveal vitreous detachmen; the following ones until six months after surgery put in evidence the DPV progression accompanied by EMC, relating it with visual symptomatology. Therefore, OCT is a useful tool for a clinical analysis but also for the contribution to research concerning the pathogenesis of diseases due to vitreo-retinal modification.
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PMID:[Posterior vitreous detachment and cystoid macular oedema post-cataract surgery: a case report]. 2255 28


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