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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Phycomycosis is the preferred terminology to define a fungal disease which may be devastating and fatal. It is caused by a nonseptate hyphae, class phycomycetes and genus (Rhizopus, Mucor, Absidia). Phycomycosis in man is usually associated with debilitating diseases such as: diabetes mellitus, leukemia and immunosuppressive conditions. The cephalic phycomycosis has two forms: 1. rhino-orbital cerebral which may be fatal, and 2. rhino-paranasal sinuses form which usually has a benign clinical course. From 1943 to 1967, only 45 cases of the cephalic form were described with a mortality rate of 50%. Since then several series have been added to the literature with improved survival, probably due to the addition of amphotericin B to the therapy. Even with modern therapy, the mortality rate is still about 30%. Modern technology C.T. scan is very helpful to establish orbital and intracranial extension. When intracranial involvement is present, the prognosis is dismal. Our series of 8 patients is reported.
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PMID:Cephalic phycomycosis: a report of eight cases. 708 43

A case report of a 60 year old female, who suffered from a perforation of the upper esophagus (broken dental prosthesis) and developed an acute candida albicans mediastinitis, is presented. There were no clinical indications for a mycosis (e.g. diabetes mellitus, esophagitis). The diagnostic criteria inclusively the role of computer-tomography as well as the surgical treatment (collar mediastinotomy) and antibiotic treatment are briefly discussed.
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PMID:[Mediastinitis with detection of Candida albicans]. 711 1

Cutaneous infection of the thumb by a Syncephalastrum sp. is described in an adult male suffering from diabetic ketosis. The fungus was isolated from the skin and was found to produce arteritis in the dermal vessels. The patient died of diabetes mellitus without any associated systemic mycosis. Syncephalastrum in this case had occurred as an opportunistic infection.
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PMID:Cutaneous infection by Syncephalastrum. 736 41

Investigations for candidiasis of the skin and mucous membranes were done in 191 probands over 65 years of age, of whon 187 were occupants of an old people's home and 4 were having in-patient treatment. In the homes being tested Candida infections of the skin and mucous membranes were very numerous (48% and 26% of those investigated) comparable with the epidemics of thrush in premature and newborn units in previous years. Even the localisation of candidiasis was remarkably similar to that in the newborn and infant age groups (Candida mycosis of the external ear and intercrural area, generalised skin candidiasis resembling Leiner's desquamating erythrodermia). The cause of cutaneous candidiasis in old age was in most cases faecal incontinence in chronically bedridden obese patients (intestinal colonisation with C. albicans). Diabetes mellitus, on the other hand, seems to play only a secondary role in the conditions of old people's homes.
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PMID:[Candida infections in geriatrics-a current problem (author's transl)]. 746 Jul 84

In our epidemiological study of 439 patients with diabetes mellitus, the proportion of Candida albicans isolated by the oral rinse technique was 67%. A comparison of the conventional germ tube test with the API 20C Auxanogram kit revealed that 23.6% (129/546) of germ tube-positive species were not identified as C. albicans by the kit. The API 20C Auxanogram therefore underestimated the prevalence of C. albicans. Additionally, a significant number of yeasts (138/1050, 13.1%) isolated from these patients could not be reliably identified by the kit.
Mycoses
PMID:Identification of oral yeast species isolated from individuals with diabetes mellitus. 747 84

Zygomycosis is an uncommon, but frequently fatal, fungal infection caused by members of the class Zygomycetes. The risk factors include diabetes mellitus, uremia, leukemia and use of deferoxamine as an iron-chelating agent; healthy persons also are occasionally infected. Those fungi, spread by their ubiquitous spores, most frequently involve the respiratory system. Rhinocerebral zygomycosis occurs predominantly in patients with uncontrolled diabetic ketoacidosis. Pulmonary zygomycosis most frequently is observed in granulocytopenic and corticosteroid-treated patients. Other clinical manifestations are gastrointestinal, cutaneous, disseminated and miscellaneous. This report concerns a previously robust farmer who suffered from left upper lung abscess caused by Rhizopus spp.-one member of the order Mucorales. Initially, it was intended to administer amphotericin B to a total dose of 2,000 mg; however, the patient could not tolerate such side effects as nausea, vomiting and refused further management when the cumulative dose was 948 mg. However, he did recover without further fever and cough. Chest X-ray, followed every three months, disclosed satisfactory improvement.
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PMID:Zygomycotic lung abscess: a case report. 755 21

Ocular signs and symptoms provide clinical clues to many of the more common metabolic and nutritional disorders seen in older adults. Diabetes mellitus can affect all parts of the eye and orbit. Complications include refractive visual loss, macular edema, retinopathy, increased risk of fungal infection, and diplopia. In patients with gout, urate crystals may precipitate in the eye and cause conjunctivitis, uveitis, or scleritis. Other problems are seen with Wilson's disease, hyperlipidemia, and albinism. Nutritional disorders usually arise from malabsorption, gastrointestinal surgery, and alcohol abuse. Deficiencies in vitamins A, B1 (thiamine), B12, and C may be manifest in the eye.
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PMID:Clues in the eye: ocular signs of metabolic and nutritional disorders. 760 60

We investigated skin diseases associated with mucocutaneous Candida infection by analyzing the clinical records of 44695 in-patients of the department of dermatology of Kiel. For more than eighty skin diseases the relative risk (RR) was calculated by age-and sex-adjusting methods. 1996 patients demonstrated a mucocutaneous candidosis, 14.8% of them being hospitalized because of extensive Candida infection. In patients with dermatomyositis, bullous pemphigus, tinea inguinalis, and condylomata acuminata a Candida infection was observed more than threefold than expected. Furthermore, patients with urticaria, folliculitis, and bullous pemphigoid demonstrated candidosis more than twice as often as control patients. In addition, patients with erysipelas, acne, psoriasis, and atopic dermatitis showed a candidosis significantly more often (RR between 1.3 and 1.6). Some internistic maladies were investigated, too. In patients presenting with diabetes mellitus, heart-insufficiency, hypertension, chronic tonsillitis, and urinary tract infection a mucocutaneous Candida infection was significantly increased.
Mycoses 1995
PMID:[Mucocutaneous candidiasis in patients with skin diseases]. 763 Mar 73

Mucormycosis is a rare fungal disease commonly affecting individuals with diabetes mellitus, hematological malignancy, and immune deficiency. Isolated pulmonary mucormycosis is extremely rare. This article reports a case of isolated pulmonary mucormycosis that presented as a solitary cavity infiltrate in a patient with no underlying risk factors.
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PMID:Isolated pulmonary mucormycosis in an apparently normal host: a case report. 767 48

Zygomycosis is a rare but highly invasive fungal infection that occurs in transplant recipients. We report a case of invasive gastrointestinal zygomycosis that occurred in a heavily immunosuppressed liver transplant recipient 5 days after retransplantation and that presented as gastric perforation. Despite aggressive surgical and antifungal therapy, the patient died. We review 46 cases of invasive zygomycosis in solid-organ transplant recipients. The rhinocerebral form of zygomycosis occurred in 57% of cases; the pulmonary, cutaneous, and disseminated forms each occurred in 13%; the renal form occurred in 2%; and the gastrointestinal form occurred in 2%. The infection ensued a median of 2 months after transplantation (range, 5 days to 8 years). Seventy-six percent of the patients had diabetes or had received antirejection therapy, mainly in the form of corticosteroids, before the onset of zygomycotic infection. The mortality for patients who received antifungal therapy and/or who underwent surgery was 50% for those who had rhinocerebral zygomycosis, none for those who had pulmonary and cutaneous zygomycosis, and 100% for those who had disseminated zygomycosis. Knowledge of the diverse clinical manifestations (including gastrointestinal involvement, as is illustrated by our case) and predisposing factors in transplant recipients with zygomycosis can aid in early recognition of this disease in this patient population.
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PMID:Invasive gastrointestinal zygomycosis in a liver transplant recipient: case report and review of zygomycosis in solid-organ transplant recipients. 775 85


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